Gene Page:APOA1

Summary?
GeneID 335
Symbol APOA1
Synonyms apo(a)
Description apolipoprotein A-I
Reference MIM:107680|HGNC:HGNC:600|Ensembl:ENSG00000118137|HPRD:02517|Vega:OTTHUMG00000046112
Gene type protein-coding
Map location 11q23-q24
帕斯卡假定值 0.635
Fetal beta -1.698

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.006
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词: schizophrenia,schizophrenic,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.3212

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PRPS2 0.71 0.76
OXCT1 0.70 0.78
LRRC4C 0.69 0.78
PAK6 0.68 0.79
DLG2 0.68 0.71
FAM102B 0.68 0.73
CDH10 0.67 0.75
TMEM196 0.67 0.65
PLCH1 0.66 0.77
LANCL2 0.66 0.73
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
IMPA2 -0.38 -0.46
IRF7 -0.35 -0.41
RAB13 -0.34 -0.44
NUDT8 -0.34 -0.32
AP002478.3 -0.33 -0.36
TEAD4 -0.33 -0.38
SLC25A20 -0.32 -0.28
ACSF2 -0.32 -0.31
DCI -0.32 -0.35
RHBDL3 -0.31 -0.32

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0001540 beta-amyloid binding IDA 11297421
GO:0005543 phospholipid binding IDA 12810715
GO:0005319 lipid transporter activity IEA -
GO:0008289 lipid binding IEA -
GO:0017127 cholesterol transporter activity IDA 9651324
GO:0017127 cholesterol transporter activity IMP 15464323
GO:0015485 cholesterol binding IDA 15464323
GO:0042802 identical protein binding 新闻学会 8049247
GO:0019899 enzyme binding 新闻学会 1587806
GO:0034191 apolipoprotein A-I receptor binding 新闻学会 16443932
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IDA 4335615
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0002740 negative regulation of cytokine secretion during immune response IDA 12458630
GO:0007186 G-protein coupled receptor protein signaling pathway IDA 16443932
GO:0008202 steroid metabolic process IEA -
GO:0008203 cholesterol metabolic process IEA -
GO:0006656 phosphatidylcholine biosynthetic process IDA 4335615
GO:0006629 lipid metabolic process IEA -
GO:0006869 lipid transport IEA -
GO:0033344 cholesterol efflux IDA 11162594|14703508|16443932
GO:0042157 lipoprotein metabolic process IEA -
GO:0050821 protein stabilization IDA 17655203
GO:0034435 cholesterol esterification IDA 4335615
GO:0032488 Cdc42 protein signal transduction IDA 16443932
GO:0033700 phospholipid efflux IDA 11162594|14703508
GO:0042632 cholesterol homeostasis IMP 15464323
GO:0050713 negative regulation of interleukin-1 beta secretion IDA 12458630
GO:0043691 reverse cholesterol transport IMP 15464323
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005788 endoplasmic reticulum lumen EXP 12692552
GO:0005576 extracellular region EXP 4345202|12692552
GO:0005576 extracellular region IEA -
GO:0030139 endocytic vesicle IDA 14747463
GO:0031410 cytoplasmic vesicle IDA 14703508
GO:0034364 high-density lipoprotein particle IDA 210174|3104518|15464323

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ABCA1 ABC-1 | ABC1 | CERP | FLJ14958 | HDLDT1 | MGC164864 | MGC165011 | TGD ATP-binding cassette, sub-family A (ABC1), member 1 Reconstituted Complex BioGRID 12084722
APOA1 MGC117399 apolipoprotein A-I - HPRD,BioGRID 9003180|9200714
|9356442
APOA1BP AIBP | MGC119143 | MGC119144 | MGC119145 | YJEFN1 apolipoprotein A-I binding protein - HPRD 11991719
APOF Apo-F | DKFZp781G18150 | LTIP | MGC22520 apolipoprotein F Co-purification BioGRID 6816269
APOL1 APO-L | APOL | APOL-I apolipoprotein L, 1 - HPRD,BioGRID 9325276
GPLD1 GPIPLD | GPIPLDM | MGC22590 | PIGPLD | PIGPLD1 glycosylphosphatidylinositol specific phospholipase D1 - HPRD,BioGRID 11254757
HPR A-259H10.2 | HP haptoglobin-related protein in vitro BioGRID 10085035
LBP MGC22233 lipopolysaccharide binding protein Affinity Capture-Western BioGRID 8663389
LCAT - lecithin-cholesterol acyltransferase Reconstituted Complex BioGRID 1644835
MAP7D1 FLJ10350 | FLJ39022 | MGC117315 | PARCC1 | RPRC1 MAP7 domain containing 1 Two-hybrid BioGRID 16169070
PDE1A HCAM1 | HSPDE1A | MGC26303 phosphodiesterase 1A, calmodulin-dependent Two-hybrid BioGRID 11991719
PLTP HDLCQ9 phospholipid transfer protein Co-purification
Reconstituted Complex		 BioGRID 9469594
PLTP HDLCQ9 phospholipid transfer protein - HPRD 11854286
SCARB1 CD36L1 | CLA-1 | CLA1 | MGC138242 | SR-BI | SRB1 清道夫受体类B, member 1 in vivo BioGRID 1076467
TNFRSF10C CD263 | DCR1 | LIT | MGC149501 | MGC149502 | TRAILR3 | TRID tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain Two-hybrid BioGRID 16169070
TOMM20 KIAA0016 | MAS20 | MGC117367 | MOM19 | TOM20 translocase of outer mitochondrial membrane 20 homolog (yeast) Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PPAR SIGNALING PATHWAY 69 47 All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 58 43 All SZGR 2.0 genes in this pathway
PID HNF3B PATHWAY 45 37 All SZGR 2.0 genes in this pathway
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 18 11 All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 104 72 All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 89 56 All SZGR 2.0 genes in this pathway
REACTOME HDL MEDIATED LIPID TRANSPORT 15 12 All SZGR 2.0 genes in this pathway
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 34 21 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT 46 37 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME LIPOPROTEIN METABOLISM 28 24 All SZGR 2.0 genes in this pathway
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT 16 15 All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 83 63 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 62 33 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 114 76 All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244 154 All SZGR 2.0 genes in this pathway
NIELSEN LIPOSARCOMA UP 18 13 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261 183 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 93 56 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 134 85 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 4 UP 19 12 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271 165 All SZGR 2.0 genes in this pathway