Gene Page:HTR1D
Summary?
| GeneID | 3352 |
| Symbol | HTR1D |
| Synonyms | 5-HT1D|HT1DA|HTR1DA|HTRL|RDC4 |
| Description | 5-hydroxytryptamine receptor 1D |
| Reference | MIM:182133|HGNC:HGNC:5289|Ensembl:ENSG00000179546|HPRD:01636|Vega:OTTHUMG00000003235 |
| Gene type | protein-coding |
| Map location | 1p36.3-p34.3 |
| Pascal p-value | 0.537 |
| eGene | Caudate basal ganglia Cortex Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans 元 |
| Support | GPCR SIGNALLING SEROTONIN |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| ADT:Sun_2012 | Systematic Investigation of Antipsychotic Drugs and Their Targets | A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes. | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2806570 | chr1 | 23527004 | HTR1D | 3352 | 0.16 | cis | ||
| rs4654830 | 1 | 23283362 | HTR1D | ENSG00000179546.3 | 3.348E-6 | 0.03 | 237860 | gtex_brain_putamen_basal |
| rs309509 | 1 | 23283380 | HTR1D | ENSG00000179546.3 | 2.525E-6 | 0.03 | 237842 | gtex_brain_putamen_basal |
| rs2294518 | 1 | 23372771 | HTR1D | ENSG00000179546.3 | 2.959E-6 | 0.03 | 148451 | gtex_brain_putamen_basal |
| rs12409321 | 1 | 23398065 | HTR1D | ENSG00000179546.3 | 2.957E-6 | 0.03 | 123157 | gtex_brain_putamen_basal |
| rs12751560 | 1 | 23407081 | HTR1D | ENSG00000179546.3 | 2.084E-6 | 0.03 | 114141 | gtex_brain_putamen_basal |
| rs2235546 | 1 | 23409538 | HTR1D | ENSG00000179546.3 | 2.959E-6 | 0.03 | 111684 | gtex_brain_putamen_basal |
| rs71020475 | 1 | 23410469 | HTR1D | ENSG00000179546.3 | 3.272E-6 | 0.03 | 110753 | gtex_brain_putamen_basal |
| rs2806563 | 1 | 23506625 | HTR1D | ENSG00000179546.3 | 3.458E-6 | 0.03 | 14597 | gtex_brain_putamen_basal |
| rs654585 | 1 | 23514714 | HTR1D | ENSG00000179546.3 | 2.279E-6 | 0.03 | 6508 | gtex_brain_putamen_basal |
| rs61777102 | 1 | 23543352 | HTR1D | ENSG00000179546.3 | 2.765E-6 | 0.03 | -22130 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004993 | serotonin receptor activity | TAS | serotonin, Neurotransmitter (GO term level: 8) | 1565658 |
| GO:0004872 | receptor activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 1565658 |
| GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | TAS | 1565658 | |
| GO:0007165 | signal transduction | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 1652050 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME AMINE LIGAND BINDING RECEPTORS | 38 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME SEROTONIN RECEPTORS | 12 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 6 | 84 | 54 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-379 | 657 | 663 | m8 | hsa-miR-379brain | UGGUAGACUAUGGAACGUA |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.