Gene Page:HTR2C

概括?
GeneID 3358
Symbol HTR2C
Synonyms 5-HT1C|5-HT2C|5-HTR2C|5HTR2C|HTR1C
描述 5-hydroxytryptamine receptor 2C
参考 MIM:312861|HGNC:HGNC:5295|ENSEMBL：ENSG00000147246|HPRD:02429|Vega:OTTHUMG00000022226
Gene type protein-coding
Map location XQ24
Fetal beta -0.534
eGene 迈尔斯的顺式和跨性别
Support Potential synaptic genes

数据源中的基因
Gene set name Method of gene set 描述 Info
ADT：SUN_2012 Systematic Investigation of Antipsychotic Drugs and Their Targets 共有382个药物目标关联涉及43种抗精神病药和49个靶基因。
CV：GWASDB 全基因组关联研究 gwasdbrecords for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur 高通量文献搜索 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008），协会研究 1 Link to SZGene
文学 高通量文献搜索 Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs3793249 chr7 29970596 HTR2C 3358 0.15 trans
rs17158518 chr7 29971956 HTR2C 3358 0.15 trans
rs17158520 chr7 29973648 HTR2C 3358 0.15 trans
rs1003749 chr7 29998723 HTR2C 3358 0.15 trans
RS10962066 chr9 15555037 HTR2C 3358 0.13 trans
RS4741528 chr9 15655977 HTR2C 3358 0.03 trans
rs6474944 chr9 15670444 HTR2C 3358 0.04 trans
rs6474952 chr9 15711233 HTR2C 3358 0.14 trans
rs10756697 chr9 15728516 HTR2C 3358 0.17 trans
RS1891212 chr9 15900770 HTR2C 3358 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
去：0004872 receptor activity IEA -
GO:0005515 protein binding 新闻学会 16319069
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007268 突触传输 塔斯 neuron, Synap, Neurotransmitter (GO term level: 6) 9241279
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007165 signal transduction IEA -
GO:0007631 feeding behavior 塔斯 7700379
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 核 IDA 18029348
GO:0005737 细胞质 IDA 18029348
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 该途径中的所有SZGR 2.0基因
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
KEGG GAP JUNCTION 90 68 该途径中的所有SZGR 2.0基因
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 该途径中的所有SZGR 2.0基因
GPCR的反应组信号传导 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 该途径中的所有SZGR 2.0基因
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 该途径中的所有SZGR 2.0基因
REACTOME SEROTONIN RECEPTORS 12 11 该途径中的所有SZGR 2.0基因
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 该途径中的所有SZGR 2.0基因
Reactome GPCR下游信号传导 805 368 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 该途径中的所有SZGR 2.0基因
LEE NEURAL CREST STEM CELL DN 118 79 该途径中的所有SZGR 2.0基因
GOZGIT ESR1 TARGETS UP 149 84 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH PRC2 TARGETS 652 441 该途径中的所有SZGR 2.0基因
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 该途径中的所有SZGR 2.0基因
LEIN MIDBRAIN MARKERS 82 55 该途径中的所有SZGR 2.0基因
LEIN PONS MARKERS 89 59 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
Han Satb1靶向 395 249 该途径中的所有SZGR 2.0基因
HAN SATB1 TARGETS DN 442 275 该途径中的所有SZGR 2.0基因
Meissner NPC HCP，含H3未甲基化 536 296 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
MIKKELSEN IPS WITH HCP H3K27ME3 102 76 该途径中的所有SZGR 2.0基因
WONG ADULT TISSUE STEM MODULE 721 492 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228 119 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
miR-124.1 2495 2501 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 2495 2501 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124脑 UAAGGCACGCGGUGAAUGCC
mir-137 2179 2185 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
mir-140 390 396 1A hsa-miR-140脑 agugguuuuacccuaugguag
mir-143 331 338 1A,m8 hsa-miR-143脑 UGAGAUGAAGCACUGUAGCUCA
mir-15/16/195/424/497 1339 1345 m8 hsa-miR-15a脑 UAGCAGCACAUAAUGGUUUGUG
HSA-MIR-16脑 uagcagcacguaaauauuggcg
hsa-miR-15b脑 UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
HSA-MIR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-182 1732 1738 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-214 1337 1343 m8 HSA-MIR-214脑 ACAGCAGGCACAGACAGGCAG
miR-216 164 170 m8 HSA-MIR-216 UAAUCUCAGCUGGCAACUGUG
miR-219 145 151 1A HSA-MIR-219脑 ugauuguccaaacgcaauucu
miR-22 1215 1221 1A HSA-MIR-22脑 AAGCUGCCAGUUGAAGAACUGU
miR-23 1077 1084 1A,m8 hsa-miR-23a脑 aucacauugccagggauucc
hsa-miR-23b脑 AUCACAUUGCCAGGGAUUACC
miR-323 1077 1083 1A HSA-MIR-323脑 GCACAUUACACGGUCGACCUCU
miR-324-3p 1671年 1677年 m8 HSA-MIR-324-3P ccacugccccaggugcugcugg
miR-326 826 832 m8 HSA-MIR-326 ccucugggcccuccag
mir-34/449 1729 1736 1A,m8 HSA-MIR-34A脑 UGGCAGUGUCUUAGCUGGUUGUU
HSA-MIR-34C AGGCAGUGUAGUUAGCUGAUUGC
HSA-MIR-449 uggcaguguauuguagcuggu
HSA-MIR-449b AGGCAGUGUAUUGUUAGCUGGC
mir-34b 2493 2499 m8 HSA-MIR-34B UAGGCAGUGUCAUUAGCUGAUUG
mir-379 1785年 1791年 m8 hsa-miR-379脑 UgguagacuauggaaCGUA
mir-384 44 50 1A hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-455 1917 1923 1A HSA-MIR-455 UAUGUGCCUUUGGACUACAUCG
miR-485-3p 2314 2320 1A HSA-MIR-485-3P GUCAUACACGGCUCUCCUCUCU
mir-495 2213 2219 1A hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
mir-496 86 92 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-96 1732 1738 1A hsa-miR-96脑 UUUGGCACUAGCACAUUUUUGC