Gene Page:HTR4

概括?
基因 3360
Symbol HTR4
Synonyms 5-HT4|5-HT4R
Description 5-hydroxytryptamine receptor 4
Reference MIM:602164|HGNC：HGNC：5299|Ensembl:ENSG00000164270|Vega:OTTHUMG00000129931
Gene type protein-coding
Map location 5q31-q33
Pascal p-value 0.469
Sherlock p-value 0.18
Fetal beta 0.26
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
ADT:Sun_2012 系统研究抗精神病药及其靶标 A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索我n PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.00459
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16892042 chr6 81347874 HTR4 3360 0.07 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004993 serotonin receptor activity IDA serotonin, Neurotransmitter (GO term level: 8) 16102731
GO:0004872 receptor activity IEA -
GO:0004935 adrenoceptor活性 IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger TAS 9603189
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007165 signal transduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005624 membrane fraction IDA 16102731
GO:0005768 endosome IEA -
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 9276448

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 该途径中的所有SZGR 2.0基因
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 该途径中的所有SZGR 2.0基因
REACTOME SIGNALING BY GPCR 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 该途径中的所有SZGR 2.0基因
REACTOME AMINE LIGAND BINDING RECEPTORS 38 33 该途径中的所有SZGR 2.0基因
REACTOME SEROTONIN RECEPTORS 12 11 该途径中的所有SZGR 2.0基因
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 该途径中的所有SZGR 2.0基因
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE FIMA DN 284 156 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS DN 357 212 该途径中的所有SZGR 2.0基因
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 该途径中的所有SZGR 2.0基因
CHESLER BRAIN D6MIT150 QTL TRANS 9 7 该途径中的所有SZGR 2.0基因
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 该途径中的所有SZGR 2.0基因
LEE AGING NEOCORTEX DN 80 49 该途径中的所有SZGR 2.0基因
dazard对紫外线nhek的反应 244 151 该途径中的所有SZGR 2.0基因
DAZARD UV RESPONSE CLUSTER G1 67 41 该途径中的所有SZGR 2.0基因
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
Yagi AML带有Inv 16易位 422 277 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
MAEKAWA ATF2 TARGETS 24 19 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 1247 1253 m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain agagguaguagguugcauagu
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-103/107 1228 1234 m8 HSA-MIR-103brain AGCAGCAUUGUACAGGGCUAUGA
HSA-MIR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-15/16/195/424/497 1229 1236 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-331 184 190 1A hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
miR-503 1230 1236 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG