Gene Page:IARS

Summary?
GeneID 3376
Symbol IARS
Synonyms IARS1|ILERS|ILRS|IRS|PRO0785
Description isoleucyl-tRNA synthetase
Reference MIM:600709|HGNC:HGNC:5330|Ensembl:ENSG00000196305|HPRD:02832|Vega:OTTHUMG00000020219
Gene type protein-coding
Map location 9q21
Pascal p-value 0.018

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
WDR61 0.86 0.82
HBXIP 0.85 0.83
SUCLG1 0.85 0.82
MRPL11 0.85 0.82
MRPL21 0.85 0.77
ASNA1 0.84 0.80
SNAPIN 0.84 0.74
TMEM85 0.84 0.80
TXN2 0.84 0.82
HAX1 0.84 0.79
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.26 -0.50 -0.57
AF347015.2 -0.48 -0.54
AF347015.18 -0.48 -0.55
AF347015.15 -0.48 -0.56
AF347015.8 -0.47 -0.54
MT-CYB -0.47 -0.54
MT-ATP8 -0.46 -0.54
SEMA3G -0.45 -0.49
FAM38A -0.44 -0.48
GATA2 -0.43 -0.48

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AKTIP FT1 | FTS AKT interacting protein Affinity Capture-MS BioGRID 17353931
BCAR3 KIAA0554 | NSP2 | SH2D3B breast cancer anti-estrogen resistance 3 Affinity Capture-MS BioGRID 17353931
EPRS DKFZp313B047 | EARS | GLUPRORS | PARS | PIG32 | QARS | QPRS glutamyl-prolyl-tRNA synthetase - HPRD,BioGRID 9556618
GARS CMT2D | DSMAV | GlyRS | HMN5 | SMAD1 glycyl-tRNA synthetase - HPRD,BioGRID 8816763
GSTK1 GST13 glutathione S-transferase kappa 1 Affinity Capture-MS BioGRID 17353931
JTV1 AIMP2 | P38 | PRO0992 JTV1 gene Two-hybrid BioGRID 9878398
MAGED1 DLXIN-1 | NRAGE melanoma antigen family D, 1 Affinity Capture-MS BioGRID 17353931
MAP3K7 TAK1 | TGF1a mitogen-activated protein kinase kinase kinase 7 - HPRD 14743216
MARS FLJ35667 | METRS | MTRNS methionyl-tRNA synthetase - HPRD 1651330|9878398
MCC DKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1 mutated in colorectal cancers Affinity Capture-MS BioGRID 17353931
SGK1 SGK serum/glucocorticoid regulated kinase 1 Affinity Capture-MS BioGRID 17353931
TRAF6 MGC:3310 | RNF85 TNF receptor-associated factor 6 Affinity Capture-MS BioGRID 17353931
TSC22D1 DKFZp686O19206 | MGC17597 | RP11-269C23.2 | TGFB1I4 | TSC22 TSC22 domain family, member 1 Affinity Capture-MS BioGRID 17353931
VHL HRCA1 | RCA1 | VHL1 von Hippel-Lindau tumor suppressor Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG VALINE LEUCINE AND ISOLEUCINE BIOSYNTHESIS 11 8 All SZGR 2.0 genes in this pathway
KEGG AMINOACYL TRNA BIOSYNTHESIS 41 33 All SZGR 2.0 genes in this pathway
ST INTERLEUKIN 4 PATHWAY 26 18 All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY 37 29 All SZGR 2.0 genes in this pathway
REACTOME CYTOSOLIC TRNA AMINOACYLATION 24 19 All SZGR 2.0 genes in this pathway
REACTOME TRNA AMINOACYLATION 42 34 All SZGR 2.0 genes in this pathway
NAKAMURA CANCER MICROENVIRONMENT DN 46 29 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
CHOI ATL CHRONIC VS ACUTE DN 18 10 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 85 57 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 141 84 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 116 71 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 UP 34 23 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
SCHUHMACHER MYC目标UP 80 57 All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA PROGNOSIS DN 43 28 All SZGR 2.0 genes in this pathway
COLLER MYC TARGETS UP 25 19 All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN 73 45 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 114 84 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172 107 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 64 47 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR 35 22 All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 84 58 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 79 45 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G23 UP 52 35 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 134 85 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
DN DELPUECH FOXO3目标 41 27 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway