Gene Page:ICAM3

Summary?
GeneID 3385
Symbol ICAM3
Synonyms CD50|CDW50|ICAM-R
Description intercellular adhesion molecule 3
Reference MIM:146631|HGNC:HGNC:5346|Ensembl:ENSG00000076662|HPRD:00889|Vega:OTTHUMG00000180410
Gene type protein-coding
Map location 19p13.2
Pascal p-value 0.19
Sherlock p-value 0.542
Fetal beta -0.519
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellum
Cortex
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 1
PMID:cooccur High-throughput literature-search 系统本身arch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg17126555 19 10445516 ICAM3 3.17E-4 0.006 0.183 DMG:Montano_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs3176767 chr19 10449750 ICAM3 3385 5.825E-6 cis
rs17151821 chr7 8628490 ICAM3 3385 0.01 trans
rs16946889 chr15 92964427 ICAM3 3385 0.06 trans
rs10853963 chr19 2909032 ICAM3 3385 0.06 trans
rs4807364 chr19 2923262 ICAM3 3385 0.08 trans
rs3176767 chr19 10449750 ICAM3 3385 9.526E-4 trans
rs2304237 19 10446568 ICAM3 ENSG00000076662.5 1.939E-9 0 3931 gtex_brain_ba24
rs1058154 19 10446897 ICAM3 ENSG00000076662.5 2.126E-9 0 3602 gtex_brain_ba24
rs74312588 19 10446900 ICAM3 ENSG00000076662.5 5.498E-9 0 3599 gtex_brain_ba24
rs3176769 19 10447034 ICAM3 ENSG00000076662.5 2.316E-9 0 3465 gtex_brain_ba24
rs10408916 19 10447770 ICAM3 ENSG00000076662.5 4.138E-9 0 2729 gtex_brain_ba24
rs10403396 19 10447819 ICAM3 ENSG00000076662.5 4.153E-9 0 2680 gtex_brain_ba24
rs7253912 19 10448555 ICAM3 ENSG00000076662.5 1.075E-8 0 1944 gtex_brain_ba24
rs7250656 19 10448566 ICAM3 ENSG00000076662.5 1.09E-8 0 1933 gtex_brain_ba24
rs7254041 19 10448636 ICAM3 ENSG00000076662.5 1.192E-8 0 1863 gtex_brain_ba24
rs7250300 19 10448660 ICAM3 ENSG00000076662.5 1.243E-8 0 1839 gtex_brain_ba24
rs7254330 19 10448876 ICAM3 ENSG00000076662.5 1.687E-8 0 1623 gtex_brain_ba24
rs7249914 19 10449009 ICAM3 ENSG00000076662.5 2.062E-8 0 1490 gtex_brain_ba24
rs7257871 19 10449252 ICAM3 ENSG00000076662.5 3.017E-8 0 1247 gtex_brain_ba24
rs7258015 19 10449358 ICAM3 ENSG00000076662.5 3.017E-8 0 1141 gtex_brain_ba24
rs3176768 19 10449665 ICAM3 ENSG00000076662.5 2.629E-9 0 834 gtex_brain_ba24
rs3176767 19 10449751 ICAM3 ENSG00000076662.5 3.017E-8 0 748 gtex_brain_ba24
rs3176766 19 10449778 ICAM3 ENSG00000076662.5 3.006E-8 0 721 gtex_brain_ba24
rs2304237 19 10446568 ICAM3 ENSG00000076662.5 2.657E-8 0 3931 gtex_brain_putamen_basal
rs1058154 19 10446897 ICAM3 ENSG00000076662.5 2.867E-8 0 3602 gtex_brain_putamen_basal
rs74312588 19 10446900 ICAM3 ENSG00000076662.5 2.53E-8 0 3599 gtex_brain_putamen_basal
rs3176769 19 10447034 ICAM3 ENSG00000076662.5 2.994E-8 0 3465 gtex_brain_putamen_basal
rs10408916 19 10447770 ICAM3 ENSG00000076662.5 4.395E-8 0 2729 gtex_brain_putamen_basal
rs10403396 19 10447819 ICAM3 ENSG00000076662.5 3.198E-8 0 2680 gtex_brain_putamen_basal
rs7253912 19 10448555 ICAM3 ENSG00000076662.5 6.458E-8 0 1944 gtex_brain_putamen_basal
rs7250656 19 10448566 ICAM3 ENSG00000076662.5 6.479E-8 0 1933 gtex_brain_putamen_basal
rs7254041 19 10448636 ICAM3 ENSG00000076662.5 6.764E-8 0 1863 gtex_brain_putamen_basal
rs7250300 19 10448660 ICAM3 ENSG00000076662.5 6.931E-8 0 1839 gtex_brain_putamen_basal
rs7254330 19 10448876 ICAM3 ENSG00000076662.5 8.077E-8 0 1623 gtex_brain_putamen_basal
rs7249914 19 10449009 ICAM3 ENSG00000076662.5 8.924E-8 0 1490 gtex_brain_putamen_basal
rs7257871 19 10449252 ICAM3 ENSG00000076662.5 1.08E-7 0 1247 gtex_brain_putamen_basal
rs7258015 19 10449358 ICAM3 ENSG00000076662.5 1.08E-7 0 1141 gtex_brain_putamen_basal
rs3176768 19 10449665 ICAM3 ENSG00000076662.5 2.548E-8 0 834 gtex_brain_putamen_basal
rs3176767 19 10449751 ICAM3 ENSG00000076662.5 1.08E-7 0 748 gtex_brain_putamen_basal
rs3176766 19 10449778 ICAM3 ENSG00000076662.5 1.081E-7 0 721 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL ADHESION MOLECULES CAMS 134 93 All SZGR 2.0 genes in this pathway
PID INTEGRIN2 PATHWAY 29 18 All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 70 37 All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 79 48 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165 106 All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 54 38 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION UP 52 32 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186 107 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER HIGH RECURRENCE 49 31 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 134 93 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 UP 17 13 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246 152 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 88 56 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway