Gene Page:STAC2
Summary?
| GeneID | 342667 |
| Symbol | STAC2 |
| Synonyms | 24b2|24b2/STAC2 |
| Description | SH3 and cysteine rich domain 2 |
| Reference | HGNC:HGNC:23990|Ensembl:ENSG00000141750|HPRD:18113|Vega:OTTHUMG00000179039 |
| Gene type | protein-coding |
| Map location | 17q12 |
| Pascal p-value | 0.002 |
| TADA p-value | 0.011 |
| Fetal beta | -0.871 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| 认为:Ambalavanan_2016 | Whole Exome Sequencing | This dataset includes 20 de novo mutations detected in 17 COS probands. | |
| 认为:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. | |
| 认为:Xu_2012 | Whole Exome Sequencing analysis | 新创4基因的突变identified by exome sequencing of 795 samples in this study |
Section I. Genetics and epigenetics annotation
认为table
认为table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| STAC2 | chr17 | 37381749 | C | T | NM_198993 | p.3E>K | missense | Schizophrenia | 认为:Fromer_2014 | ||
| STAC2 | chr17 | 37374188 | A | G | NM_198993 | p.110L>P | missense | Schizophrenia | 认为:Xu_2012 | ||
| STAC2 | chr17 | 37374260 | C | T | NM_198993 | p.(Arg86Lys) | nonsynonymous SNV | Childhood-onset schizophrenia | 认为:Ambalavanan_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 | 349 | 234 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL UP | 489 | 314 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL MATURE DN | 99 | 74 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |