Gene Page:ifit1

Summary？
基因 3434
象征 ifit1
Synonyms C56|G10P1|IFI-56|IFI-56K|IFI56|IFIT-1|IFNAI1|ISG56|P56|RNM561
Description 干扰素诱导的四肽重复蛋白1
Reference MIM:147690|HGNC:HGNC:5407|Ensembl:ENSG00000185745|HPRD:00983|
基因类型 蛋白质编码
Map location 10 q23.31
Pascal p-value 0.484
Sherlock p-value 0.493
胎儿β -3.017
主持人 Cerebellar Hemisphere
小脑
Hypothalamus
伏隔核基底神经节
Putamen basal ganglia
Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation

@EQTL注释

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS488615 Chr11 120054318 ifit1 3434 0.05 反式
RS304493 10 91142586 ifit1 ENSG00000185745.8 2.32069E-6 0.04 -9717 gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene 皮尔逊的相关性 斯皮尔曼的相关性
AGGF1 0.90 0.88
TM9SF3 0.88 0.89
KIAA0232 0.88 0.89
EIF2AK2 0.87 0.89
TMEM184C 0.87 0.87
Krit1 0.87 0.87
FMR1 0.86 0.86
ZDHHC17 0.86 0.86
USO1 0.85 0.86
ZNF800 0.85 0.89
Top 10 negatively co-expressed genes
Gene 皮尔逊的相关性 斯皮尔曼的相关性
AF347015.21 -0.65 -0.57
MT-CO2 -0.63 -0.61
AF347015.31 -0.63 -0.61
HIGD1B -0.62 -0.60
AF347015.8 -0.60 -0.58
mt-cyb -0.60 -0.56
AF347015.2 -0.59 -0.56
ifi27 -0.59 -0.57
FXYD1 -0.59 -0.57
ENHO -0.59 -0.69

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 66 45 All SZGR 2.0 genes in this pathway
Reactome干扰素αβ信号传导 64 50 All SZGR 2.0 genes in this pathway
Reactome干扰素信号传导 159 116 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS DN 463 290 All SZGR 2.0 genes in this pathway
Gary CD5目标DN 431 263 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186 114 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN 74 44 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 8D的Takeda目标 157 91 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 10D的Takeda目标 194 122 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 16D的Takeda目标 175 108 All SZGR 2.0 genes in this pathway
Mullighan MLL签名1 DN 242 165 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合单核细胞的TONKS目标 204 140 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
Kim WT1靶向DN 459 276 All SZGR 2.0 genes in this pathway
Kim WT1靶向12小时 162 116 All SZGR 2.0 genes in this pathway
Gozgit ESR1靶向DN 781 465 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
Castellano NRAS靶向 68 41 All SZGR 2.0 genes in this pathway
Markey RB1急性lof 215 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡 1142 669 All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向E 97 60 All SZGR 2.0 genes in this pathway
OUELLET卵巢癌浸润性对LMP 117 85 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 All SZGR 2.0 genes in this pathway
Perez TP53目标 1174 695 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6 84 54 All SZGR 2.0 genes in this pathway
农民乳腺癌簇1 44 23 All SZGR 2.0 genes in this pathway
Bowie对细胞外基质的反应 17 11 All SZGR 2.0 genes in this pathway
鲍伊对他莫昔芬的反应 18 10 All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 6HR 19 8 All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 6HR 27 18 All SZGR 2.0 genes in this pathway
癌症中的EINAV干扰素签名 27 16 All SZGR 2.0 genes in this pathway
Dauer Stat3靶向DN 50 34 All SZGR 2.0 genes in this pathway
Seitz肿瘤转化通过8p删除 73 47 All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 50 27 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
通过ELK3和HIF1A DN的缺氧总缺氧 103 71 All SZGR 2.0 genes in this pathway
锯齿状斑瘤肿瘤发生RET C634R 11 7 All SZGR 2.0 genes in this pathway
Benporath循环基因 648 385 All SZGR 2.0 genes in this pathway
张对IKK抑制剂和TNF的反应 223 140 All SZGR 2.0 genes in this pathway
BYSTRYKH造血细胞和脑QTL Trans 185 114 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 71 51 All SZGR 2.0 genes in this pathway
der ifn alpha响应 74 48 All SZGR 2.0 genes in this pathway
贝克莫昔芬的抵抗 50 36 All SZGR 2.0 genes in this pathway
Radaeva对IFNA1的响应 52 40 All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 102 67 All SZGR 2.0 genes in this pathway
Grandvaux IRF3靶向 15 12 All SZGR 2.0 genes in this pathway
sana tnf发出信号 83 56 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
HALMOS CEBPA目标DN 46 26 All SZGR 2.0 genes in this pathway
Roeth Tert目标 14 11 All SZGR 2.0 genes in this pathway
Li Wilms肿瘤与胎儿肾脏1 182 119 All SZGR 2.0 genes in this pathway
MLL AF9融合的Kumar目标 405 264 All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2 53 34 All SZGR 2.0 genes in this pathway
葡萄病毒感染的Debiasi凋亡 314 201 All SZGR 2.0 genes in this pathway
马尔基尼trabectedin抗性 21 16 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
Chen LVAD支持失败的心脏DN 42 32 All SZGR 2.0 genes in this pathway
由HPV31 DN永生 65 45 All SZGR 2.0 genes in this pathway
Krasnoselskaya ILF3靶向 38 24 All SZGR 2.0 genes in this pathway
Zhu CMV全部 120 89 All SZGR 2.0 genes in this pathway
张抗病毒对利巴韦林的反应 30 21 All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 35 21 All SZGR 2.0 genes in this pathway
李小脑老化 84 58 All SZGR 2.0 genes in this pathway
杰克逊DNMT1靶向 77 57 All SZGR 2.0 genes in this pathway
Sesto对UV C1的反应 72 45 All SZGR 2.0 genes in this pathway
盖斯对dsrna的响应 38 29 All SZGR 2.0 genes in this pathway
Zhu CMV 24小时 93 65 All SZGR 2.0 genes in this pathway
玛丽亚达森对姜黄素苏琳克5的反应 23 17 All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN 434 302 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 47 39 All SZGR 2.0 genes in this pathway
道格拉斯BMI1靶向DN 314 188 All SZGR 2.0 genes in this pathway
Kim LRC3B目标 30 24 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON UP 77 47 All SZGR 2.0 genes in this pathway
海勒被甲基化沉默 282 183 All SZGR 2.0 genes in this pathway
Heller HDAC靶向 317 208 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛 299 167 All SZGR 2.0 genes in this pathway
Worschech肿瘤排斥 56 32 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
Moserle IFNA响应 31 19 All SZGR 2.0 genes in this pathway
CADWELL ATG16L1靶向 93 56 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 148 83 All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION UP 20 10 All SZGR 2.0 genes in this pathway
croonquist nras发出信号 41 24 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
Jison Sickle细胞疾病 181 106 All SZGR 2.0 genes in this pathway
Boyault肝癌子类G3 DN 51 32 All SZGR 2.0 genes in this pathway
Mikkelsen MEF LCP带有H3K4ME3 128 68 All SZGR 2.0 genes in this pathway
TSAI DNAJB4 TARGETS UP 13 8 All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S3 266 180 All SZGR 2.0 genes in this pathway
由MYC DN监管 253 192 All SZGR 2.0 genes in this pathway
Dorn腺病毒感染12小时 29 18 All SZGR 2.0 genes in this pathway
黄成人组织茎模块 721 492 All SZGR 2.0 genes in this pathway
YAO对孕酮簇9的时间反应9 76 45 All SZGR 2.0 genes in this pathway
Baus TFF2靶向 32 22 All SZGR 2.0 genes in this pathway
Browne HCMV感染4小时 55 41 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 162 86 All SZGR 2.0 genes in this pathway
惠特菲尔德细胞周期M G1 148 95 All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 50 24 All SZGR 2.0 genes in this pathway
Stambolsky对维生素D3的反应 84 48 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
lu eszh2靶向 295 155 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标2 UP 140 94 All SZGR 2.0 genes in this pathway
Winzen通过KHSRP退化 100 70 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向DN 784 464 All SZGR 2.0 genes in this pathway
Pedrioli mir31靶向DN 418 245 All SZGR 2.0 genes in this pathway
BOSCO干扰素诱导的抗病毒模块 78 48 All SZGR 2.0 genes in this pathway
Altemeier对LPS具有机械通气的反应 128 81 All SZGR 2.0 genes in this pathway
Durand Stroma S向上 297 194 All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上 1839 928 All SZGR 2.0 genes in this pathway
Zwang EGF间隔DN 214 124 All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 95 54 All SZGR 2.0 genes in this pathway