Gene Page:IFNB1

Summary?
GeneID 3456
Symbol IFNB1
Synonyms IFB|IFF|IFN-beta|IFNB
Description interferon, beta 1, fibroblast
Reference MIM:147640|HGNC:HGNC:5434|Ensembl:ENSG00000171855|HPRD:00972|Vega:OTTHUMG00000019652
Gene type protein-coding
Map location 9p21
Pascal p-value 0.175

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26页ostconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EIF3H 0.97 0.95
RPL4 0.97 0.94
KARS 0.96 0.95
CCT3 0.96 0.95
BTF3 0.96 0.96
TUT1 0.95 0.87
POLR1D 0.95 0.93
MRPL45 0.95 0.94
TEX10 0.94 0.93
NACA 0.94 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HLA-F -0.68 -0.79
AF347015.33 -0.68 -0.85
AF347015.27 -0.67 -0.83
MT-CO2 -0.67 -0.83
AIFM3 -0.67 -0.78
MT-CYB -0.66 -0.84
AF347015.31 -0.66 -0.82
AF347015.8 -0.65 -0.84
TINAGL1 -0.65 -0.78
AF347015.15 -0.64 -0.83

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 71 51 All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 56 44 All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155 105 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
BIOCARTA RANKL PATHWAY 14 13 All SZGR 2.0 genes in this pathway
BIOCARTA CYTOKINE PATHWAY 22 16 All SZGR 2.0 genes in this pathway
BIOCARTA INFLAM通路 29 24 All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY 22 20 All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 33 29 All SZGR 2.0 genes in this pathway
ST TYPE I INTERFERON PATHWAY 9 8 All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 82 63 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 30 26 All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132 101 All SZGR 2.0 genes in this pathway
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 14 10 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 64 50 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNA SIGNALING 24 22 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159 116 All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 73 57 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS DN 25 18 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 85 54 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6 11 9 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 41 28 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 51 32 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 71 48 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 47 39 All SZGR 2.0 genes in this pathway
ISHIKAWA STING SIGNALING 8 6 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
ZHANG INTERFERON RESPONSE 23 14 All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 30 19 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway