Gene Page:IFNG

Summary？
基因 3458
象征 IFNG
Synonyms IFG|IFI
Description 干扰素，伽玛
Reference MIM:147570|HGNC:HGNC:5438|ENSEMBL：ENSG00000111537|HPRD:00957|Vega：Otthumg00000169113
基因类型 蛋白质编码
Map location 12Q14
Pascal p-value 0.719
主持人 Myers' cis & trans
元

Gene in Data Sources
基因集名称 Method of gene set Description 信息
简历：Gwascat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@eQTL注释

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS16869851 CHR4 20690056 IFNG 3458 0.04 反式
RS10994209 Chr10 61877705 IFNG 3458 0.15 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005133 干扰素γ受体结合 TAS 10477596
去：0005125 细胞因子活性 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO：0031642 负调节髓鞘 IEA axon (GO term level: 15) -
去：0000060 蛋白质进口到核，易位 艾达 15604419
GO:0001558 细胞生长调节 IEA -
GO:0001781 neutrophil apoptosis IEA -
GO:0007166 cell surface receptor linked signal transduction TAS 10477596
去：0007050 cell cycle arrest 艾达 16942485
GO：0019882 抗原处理和演示 IEA -
GO:0048304 positive regulation of isotype switching to IgG isotypes IEA -
去：0009615 response to virus IEA -
GO:0006928 细胞运动 TAS 10477596
GO:0006925 炎性细胞凋亡 IEA -
GO：0042508 Stat1蛋白的酪氨酸磷酸化 艾达 15604419
去：0030968 内质网展开的蛋白质反应 IEA -
GO：0042742 defense response to bacterium IEA -
GO：0032735 positive regulation of interleukin-12 production 艾达 7605994|8557999
GO:0034393 平滑肌细胞凋亡的正调控 艾达 16942485
去：0030593 neutrophil chemotaxis IEA -
GO：0045893 转录，DNA依赖性的阳性调节 IEA -
GO:0050718 白介素-1 beta分泌的积极调节 IEA -
GO：0050776 regulation of immune response IEA -
GO：0045084 白介素12生物合成过程的阳性调节 IEA -
GO：0045080 趋化因子生物合成过程的阳性调节 IEA -
GO:0045348 positive regulation of MHC class II biosynthetic process IEA -
GO:0048662 平滑肌细胞增殖的负调节 艾达 16942485
GO：0045410 白介素6生物合成过程的正调节 IEA -
GO：0045429 positive regulation of nitric oxide biosynthetic process 艾达 8383325
GO:0045449 转录的调节 IEA -
去：0050796 胰岛素分泌的调节 艾达 8383325
GO:0051712 另一生物细胞杀死的积极调节 艾达 7544003
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 IEA -
去：0005615 细胞外空间 IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg蛋白酶体 48 28 All SZGR 2.0 genes in this pathway
KEGG细胞因子细胞因子受体相互作用 267 161 All SZGR 2.0 genes in this pathway
自噬调节 35 30 All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
kegg jak stat信号通路 155 105 All SZGR 2.0 genes in this pathway
kegg天然杀伤细胞介导的细胞毒性 137 92 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG TYPE I DIABETES MELLITUS 44 38 All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 72 56 All SZGR 2.0 genes in this pathway
kegg系统性狼疮红斑 140 100 All SZGR 2.0 genes in this pathway
KEGG同种异体拒绝 38 34 All SZGR 2.0 genes in this pathway
KEGG移植与宿主疾病 42 31 All SZGR 2.0 genes in this pathway
生物卡塔尔粒细胞途径 14 9 All SZGR 2.0 genes in this pathway
Biocarta TID途径 19 15 All SZGR 2.0 genes in this pathway
生物卡塔尔细胞因子途径 22 16 All SZGR 2.0 genes in this pathway
Biocarta fordam途径 29 24 All SZGR 2.0 genes in this pathway
Biocarta DC途径 22 20 All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY 23 17 All SZGR 2.0 genes in this pathway
BIOCARTA NO2IL12 PATHWAY 17 14 All SZGR 2.0 genes in this pathway
Biocarta TOB1途径 21 14 All SZGR 2.0 genes in this pathway
BIOCARTA NKT PATHWAY 29 21 All SZGR 2.0 genes in this pathway
BIOCARTA TH1TH2 PATHWAY 19 14 All SZGR 2.0 genes in this pathway
Biocarta 41BB途径 17 15 All SZGR 2.0 genes in this pathway
St Interferon Gamma途径 10 7 All SZGR 2.0 genes in this pathway
PID IL27途径 26 20 All SZGR 2.0 genes in this pathway
PID IL12 2 Pathway 63 54 All SZGR 2.0 genes in this pathway
pid nfat tfpathway 47 39 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID端粒酶途径 68 48 All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 55 43 All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 40 34 All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 59 43 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
PID IL23途径 37 30 All SZGR 2.0 genes in this pathway
PID PDGFRA途径 22 18 All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY 29 23 All SZGR 2.0 genes in this pathway
PID CD8 TCR下游途径 65 56 All SZGR 2.0 genes in this pathway
PID IL12 STAT4途径 33 29 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNG SIGNALING 14 10 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING 63 48 All SZGR 2.0 genes in this pathway
Reactome干扰素信号传导 159 116 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 All SZGR 2.0 genes in this pathway
Deurig t细胞促进性白血病DN 320 184 All SZGR 2.0 genes in this pathway
多德鼻咽癌DN 1375 806 All SZGR 2.0 genes in this pathway
kokkinakis甲硫氨酸剥夺48小时DN 64 39 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
标记HDAC目标DN 15 11 All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络 1442 892 All SZGR 2.0 genes in this pathway
弗里德曼衰老 77 60 All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇1 13 11 All SZGR 2.0 genes in this pathway
Nikolsky乳腺癌12q13 Q21 Amplicon 46 21 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
卫生部对干扰素beta的反应 71 49 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病初期 390 242 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
Browne HCMV感染48小时DN 504 323 All SZGR 2.0 genes in this pathway
Browne HCMV感染18小时DN 178 121 All SZGR 2.0 genes in this pathway
结肠癌中甲基化的甲基化 27 20 All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定 491 310 All SZGR 2.0 genes in this pathway
H3K27me3 196 93 All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛 299 167 All SZGR 2.0 genes in this pathway
Worschech肿瘤排斥 56 32 All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记DN 138 92 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN 366 257 All SZGR 2.0 genes in this pathway
Budhu肝癌转移DN 7 7 All SZGR 2.0 genes in this pathway
MARSON FOXP3目标DN 54 38 All SZGR 2.0 genes in this pathway
ONO AML1靶向 24 14 All SZGR 2.0 genes in this pathway
Seike肺癌生存不佳 11 8 All SZGR 2.0 genes in this pathway
黑元对癌细胞病毒的反应 44 30 All SZGR 2.0 genes in this pathway
黑元对癌细胞病毒和环状RGD的反应 21 15 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
Browne HCMV感染30分钟DN 150 99 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway
NABA分泌因素 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-29 475 481 M8 HSA-MIR-29ASZ UAGCACCAUCUGAAAUCGGUU
HSA-MIR-29BSZ UAGCACCAUUUGAAAUCAGUGUU
HSA-MIR-29CSZ uagcaccauuugaaaucggu