Gene Page:IGF1

Summary？
GeneID 3479
Symbol IGF1
Synonyms IGF-I|IGFI|MGF
Description insulin like growth factor 1
Reference MIM:147440|HGNC:HGNC:5464|Ensembl：ENSG0000000017427|HPRD:00936|Vega:OTTHUMG00000149910
基因类型 蛋白质编码
Map location 12q23.2
Pascal p-value 0.339
胎儿β -1.233
主持人 Cerebellar Hemisphere
Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
GO_Annotation 将与神经相关的关键字映射到基因本体论注释 Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 eQTL type
RS1911875 CHR4 132293356 IGF1 3479 0.12 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0005179 激素活性 IEA -
GO:0005179 激素活性 TAS 9681507
去：0005159 胰岛素样生长因子受体结合 IPI 8452530
去：0005159 胰岛素样生长因子受体结合 TAS 10749889
去：0005158 胰岛素受体结合 IPI 8452530
去：0005515 蛋白质结合 IEA -
去：0005515 蛋白质结合 IPI 10766744
GO:0008083 生长因子活性 IEA -
Biological process 去学期 证据 神经关键字 PubMed ID
GO:0010001 神经胶质细胞分化 IEA 神经胶质（GO期限：8） -
GO:0007399 nervous system development IEA 神经突（GO期限：5） -
GO:0001501 skeletal system development TAS 10448861
去:0030104 水稳态 IEA -
GO:0007265 RAS蛋白信号转导 TAS 10848592
GO:0006260 基因复制 TAS 10766744
GO:0009887 organ morphogenesis IEA -
GO:0007165 signal transduction TAS 10448861
GO：0048468 cell development IEA -
去：0007517 肌肉发育 TAS 10448861
去：0007605 sensory perception of sound IEA -
GO:0009441 糖酸代谢过程 TAS 10448861
GO：0048015 phosphoinositide-mediated signaling IDA 7692086
GO:0006928 cell motion TAS 10766744
GO:0006916 抗凋亡 IDA 16942485
GO:0006916 抗凋亡 IEA -
GO：0014065 磷酸肌醇3-激酶级联反应 IDA 7688386
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein IDA 9722506
GO:0033143 类固醇激素受体信号通路的调节 IDA 10459853
去:0014834 satellite cell maintenance involved in skeletal muscle regeneration IDA 17531227
GO:0014896 muscle hypertrophy IMP 10191278
GO:0014904 myotube cell development IDA 17531227
GO:0014911 positive regulation of smooth muscle cell migration IDA 10766744
GO：0021940 颗粒细胞前体增殖的阳性调节 IEA -
GO:0043193 基因特异性转录的阳性调节 IDA 9722506
GO:0048754 branching morphogenesis of a tube IEA -
GO：0051246 regulation of protein metabolic process IEA -
GO：0030879 mammary gland development IEA -
GO:0034392 平滑肌细胞凋亡的负调控 IDA 16942485
GO：0035264 多细胞生物生长 IEA -
GO:0045740 DNA复制的阳性调节 IDA 7688386|9722506
GO：0045944 RNA聚合酶II启动子的转录阳性调节 IEA -
GO:0045840 有丝分裂的阳性调节 IDA 7188854
GO：0048146 positive regulation of fibroblast proliferation IDA 7188854
GO：0050650 chondroitin sulfate proteoglycan biosynthetic process IEA -
去：0050679 positive regulation of epithelial cell proliferation IDA 7188854
GO：0045821 糖酵解的阳性调节 IDA 7688386
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IDA 7688386|10766744
GO:0046579 positive regulation of Ras protein signal transduction IDA 9722506
GO:0048661 平滑肌细胞增殖的阳性调节 IDA 10766744|16942485
GO:0045445 成肌细胞差异 IDA 17531227
GO:0051450 myoblast proliferation IDA 17531227
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 EXP 2752154
去：0005576 细胞外区域 IEA -
去：0005576 细胞外区域 nas 14718574
去：0005615 extracellular space IEA -
GO:0016942 insulin-like growth factor binding protein complex 我知道了 10766744
GO:0031093 血小板α颗粒管腔 EXP 2752154

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
IDE FLJ35968 | INSULYSIN 降解酶 重构的复合物 Biogrid 1733942
IGF1R CD221 |igfir |JTK13 |MGC142170 |MGC142172 |MGC18216 insulin-like growth factor 1 receptor IGF-I与IGF-IR相互作用。这种相互作用是基于未指定物种与人IGF-IR的IGF-I之间的相互作用进行建模的。 绑定 15604363
IGF1R CD221 |igfir |JTK13 |MGC142170 |MGC142172 |MGC18216 insulin-like growth factor 1 receptor - HPRD,BioGRID 1852007
igfals ALS insulin-like growth factor binding protein, acid labile subunit - HPRD,BioGRID 9497324|10823924
IGFBP1 AFBP | IBP1 | IGF-BP25 | PP12 | hIGFBP-1 insulin-like growth factor binding protein 1 - HPRD,BioGRID 10350456
IGFBP1 AFBP | IBP1 | IGF-BP25 | PP12 | hIGFBP-1 insulin-like growth factor binding protein 1 IGF-I与IGFBP-1相互作用。 绑定 10407151
IGFBP2 IBP2 |IGF-BP53 胰岛素样生长因子结合蛋白2，36KDA IGF-I与IGFBP-2相互作用。 绑定 10407151
IGFBP2 IBP2 |IGF-BP53 胰岛素样生长因子结合蛋白2，36KDA - HPRD,BioGRID 11063745
IGFBP3 BP-53 |IBP3 insulin-like growth factor binding protein 3 - HPRD,BioGRID 11600567
IGFBP3 BP-53 |IBP3 insulin-like growth factor binding protein 3 IGF-I与IGFBP-3相互作用。 绑定 10407151
IGFBP4 BP-4 | HT29-IGFBP | IBP4 | IGFBP-4 insulin-like growth factor binding protein 4 - HPRD,BioGRID 9722589
IGFBP4 BP-4 | HT29-IGFBP | IBP4 | IGFBP-4 insulin-like growth factor binding protein 4 IGF-I与IGFBP-4相互作用。 绑定 10407151
IGFBP5 IBP5 insulin-like growth factor binding protein 5 IGF-I与IGFBP-5相互作用。 绑定 10407151
IGFBP5 IBP5 insulin-like growth factor binding protein 5 - HPRD,BioGRID 9497324
IGFBP6 IBP6 胰岛素样生长因子结合蛋白6 IGF-I与IGFBP-6相互作用。 绑定 10407151
IGFBP6 IBP6 胰岛素样生长因子结合蛋白6 - HPRD 7683646
IGFBP7 FSTL2 | IGFBP-7 | IGFBP-7v | IGFBPRP1 | MAC25 | PSF 胰岛素样生长因子结合蛋白7 - HPRD,BioGRID 8939990
IGSF1 IGCD1 | IGDC1 | INHBP | KIAA0364 | MGC75490 | PGSF2 免疫球蛋白超家族，成员1 - HPRD,BioGRID 11344214
NOV CCN3 | IGFBP9 nephroblastoma overexpressed gene - HPRD,BioGRID 10084601
TF DKFZp781D0156 | PRO1557 | PRO2086 转铁蛋白 重构的复合物 Biogrid 11749962


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Kegg卵母细胞减数分裂 114 79 All SZGR 2.0 genes in this pathway
KEGG P53信号通路 69 45 All SZGR 2.0 genes in this pathway
kegg mtor信号通路 52 40 All SZGR 2.0 genes in this pathway
kegg焦点粘附 201 138 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 86 59 All SZGR 2.0 genes in this pathway
KEGG醛固酮调节的钠重吸收 42 29 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
KEGG GLIOMA 65 56 All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 89 75 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
KEGG扩张心肌病 92 68 All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY 32 25 All SZGR 2.0 genes in this pathway
BIOCARTA ERYTH PATHWAY 15 11 All SZGR 2.0 genes in this pathway
Biocarta IGF1途径 21 16 All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 56 45 All SZGR 2.0 genes in this pathway
Biocarta坏路 26 23 All SZGR 2.0 genes in this pathway
BIOCARTA IGF1MTOR PATHWAY 20 14 All SZGR 2.0 genes in this pathway
BIOCARTA LONGEVITY PATHWAY 15 13 All SZGR 2.0 genes in this pathway
SIG PIP3在心脏肌周期中发出信号 67 54 All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY 41 35 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID IGF1途径 30 23 All SZGR 2.0 genes in this pathway
PID神经酰胺途径 48 37 All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 75 53 All SZGR 2.0 genes in this pathway
PID Ecadherin稳定途径 42 34 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP 69 38 All SZGR 2.0 genes in this pathway
Corre多发性骨髓瘤DN 62 41 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
IGF1和IGF2的Pacher靶标 35 27 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238 135 All SZGR 2.0 genes in this pathway
障碍癌复发正常样本 32 21 All SZGR 2.0 genes in this pathway
哈马凋亡通过Trail Up 584 356 All SZGR 2.0 genes in this pathway
BUSA SAM68 TARGETS DN 6 5 All SZGR 2.0 genes in this pathway
Li Wilms肿瘤与胎儿肾脏2 30 24 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM4 261 153 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN 2FC DN 21 13 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
GALIE肿瘤血管生成 8 7 All SZGR 2.0 genes in this pathway
Bertucci侵入性癌导管与小叶DN 46 34 All SZGR 2.0 genes in this pathway
FLI1和DAX1 DN的Garcia目标 176 104 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN 45 33 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER F 54 32 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 65 44 All SZGR 2.0 genes in this pathway
Lee Liver Cancer Myc E2F1 DN 64 38 All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN 309 206 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC DN 63 40 All SZGR 2.0 genes in this pathway
Lee肝癌E2F1 DN 64 42 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
郭十六进制靶向DN 65 36 All SZGR 2.0 genes in this pathway
iglesias e2f目标dn 16 11 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上 428 266 All SZGR 2.0 genes in this pathway
LIU SMARCA4 TARGETS 64 39 All SZGR 2.0 genes in this pathway
Burton脂肪形成峰在0hr 63 48 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS UP 26 17 All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP 49 40 All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER DN 20 11 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 63 44 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170 107 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN LUNG DN 37 22 All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 84 52 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
Izadpanah干细胞脂肪与骨DN 108 68 All SZGR 2.0 genes in this pathway
MATZUK EARLY ANTRAL FOLLICLE 13 11 All SZGR 2.0 genes in this pathway
Boquest干细胞向上 260 174 All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜 425 298 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH DN 31 25 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记DN 138 92 All SZGR 2.0 genes in this pathway
WU被膀胱癌中的甲基化沉默 55 42 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
Liu Vav3前列腺致癌作用 89 61 All SZGR 2.0 genes in this pathway
ZHAN LATE DIFFERENTIATION GENES UP 33 24 All SZGR 2.0 genes in this pathway
Hoshida肝癌生存DN 113 76 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP 47 38 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K4ME3 AND H3K27ME3 34 21 All SZGR 2.0 genes in this pathway
NAKAYAMA FGF2 TARGETS 29 17 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210 141 All SZGR 2.0 genes in this pathway
Nakayama软组织肿瘤PCA2 DN 80 51 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 137 85 All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应11 103 68 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS SKIN DN 27 15 All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS UP 53 39 All SZGR 2.0 genes in this pathway
Katsanou Elavl1靶向 169 105 All SZGR 2.0 genes in this pathway
Servitja肝HNF1A靶向DN 157 105 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway
NABA分泌因素 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 151 158 1A，M8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-142-5p 4421 4428 1A，M8 hsa-miR-142-5p cauaaaguagaaagcacuac
miR-150 3590 3597 1A，M8 HSA-MIR-150 UCUCCCAACCCUUGUACCAGUG
miR-18 181 187 M8 HSA-MIR-18A UAAGGUGCAUCUAGUGCAGAUA
HSA-MIR-18B UAAGGUGCAUCUAGUGCAGUUA
miR-186 3676 3682 1A HSA-MIR-186 CAAAGAAUUCUCCUUUUGGGCUU
HSA-MIR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 178 184 M8 HSA-MIR-19A UGUGCAAAUCUAUGCAAAACUGA
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
miR-26 3689 3695 M8 HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
miR-27 4376 4382 1A HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
miR-29 3664 3671 1A，M8 HSA-MIR-29ASZ UAGCACCAUCUGAAAUCGGUU
HSA-MIR-29BSZ UAGCACCAUUUGAAAUCAGUGUU
HSA-MIR-29CSZ UAGCACCAUUUGAAAUCGGU
HSA-MIR-29ASZ UAGCACCAUCUGAAAUCGGUU
HSA-MIR-29BSZ UAGCACCAUUUGAAAUCAGUGUU
HSA-MIR-29CSZ UAGCACCAUUUGAAAUCGGU
mir-30-3p 3278 3284 1A HSA-MIR-30A-3P CUUUCAGUCGGAUGUUUGCAGC
HSA-MIR-30E-3P CUUUCAGUCGGAUGUUUACAGC
mir-320 640 646 1A hsa-miR-320 aaaagcugggugagaggggcgaa
miR-409-3p 150 156 M8 HSA-MIR-409-3P CGAAUGUUGCUCGGUGAACCCCU
miR-486 855 861 1A HSA-MIR-486 uccuguacugagcugcccccgag
miR-495 916 923 1A，M8 HSA-MIR-495brain Aaacaaacauggugcacuuuuu
miR-496 832 838 1A HSA-MIR-496 AUUACAUGGCCAAUCUC
HSA-MIR-496 AUUACAUGGCCAAUCUC