Gene Page:IGF2R

Summary?
GeneID 3482
Symbol IGF2R
Synonyms CD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRI
Description insulin like growth factor 2 receptor
Reference MIM:147280|HGNC:HGNC:5467|HPRD:00928|
Gene type protein-coding
Map location 6q26
Pascal p-value 0.248
Fetal beta 0.06
DMG 1 (# studies)
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 2
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg12754982 6 160409942 IGF2R 1.86E-4 0.008 0.152 DMG:Montano_2016
cg23344523 6 160380572 IGF2R 3.6E-4 0.006 0.193 DMG:Montano_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005010 insulin-like growth factor receptor activity TAS 10799489
GO:0004872 receptor activity TAS 7753549
GO:0005515 protein binding IEA -
GO:0005520 insulin-like growth factor binding IEA -
GO:0005215 transporter activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007165 signal transduction TAS 7753549
GO:0006810 transport IEA -
GO:0006898 receptor-mediated endocytosis TAS 10799489
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005641 nuclear envelope lumen IEA -
GO:0005737 cytoplasm IEA -
GO:0005765 lysosomal membrane IEA -
GO:0005768 endosome IDA 15078902
GO:0016020 membrane IEA -
GO:0005887 integral to plasma membrane TAS 10799489
GO:0030140 trans-Golgi network transport vesicle IDA 15078902

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AGA AGU | ASRG | GA aspartylglucosaminidase - HPRD 9362483
CREG1 CREG cellular repressor of E1A-stimulated genes 1 - HPRD,BioGRID 12934103
CTSD CLN10 | CPSD | MGC2311 cathepsin D CTSD (CD) interacts with IGF2R (MPR300). BIND 15258139
GGA1 - golgi associated, gamma adaptin ear containing, ARF binding protein 1 - HPRD 11387475|11390366
GGA2 FLJ20966 | KIAA1080 | VEAR golgi associated, gamma adaptin ear containing, ARF binding protein 2 - HPRD 11387476
GGA2 FLJ20966 | KIAA1080 | VEAR golgi associated, gamma adaptin ear containing, ARF binding protein 2 - HPRD 11387475|11387476
GGA3 KIAA0154 golgi associated, gamma adaptin ear containing, ARF binding protein 3 - HPRD 11387475
GZMB CCPI | CGL-1 | CGL1 | CSP-B |乳腺叶状囊肉瘤| CTLA1 | CTSGL1 | HLP | SECT granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) - HPRD 11081635
M6PRBP1 MGC11117 | MGC2012 | PP17 | TIP47 mannose-6-phosphate receptor binding protein 1 M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). BIND 9590177
M6PRBP1 MGC11117 | MGC2012 | PP17 | TIP47 mannose-6-phosphate receptor binding protein 1 - HPRD,BioGRID 9590177|10908666
M6PRBP1 MGC11117 | MGC2012 | PP17 | TIP47 mannose-6-phosphate receptor binding protein 1 M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). BIND 10908666
M6PRBP1 MGC11117 | MGC2012 | PP17 | TIP47 mannose-6-phosphate receptor binding protein 1 M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). BIND 11359012
M6PRBP1 MGC11117 | MGC2012 | PP17 | TIP47 mannose-6-phosphate receptor binding protein 1 M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). BIND 12032303
M6PRBP1 MGC11117 | MGC2012 | PP17 | TIP47 mannose-6-phosphate receptor binding protein 1 M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). BIND 10829017
M6PRBP1 MGC11117 | MGC2012 | PP17 | TIP47 mannose-6-phosphate receptor binding protein 1 TIP47 interacts with CI-MPR. This interaction was modeled on a demostrated interaction between a modified synthetic peptide representing human TIP47 and CI-MPR from an unspecified species. BIND 15782153
PACS1 FLJ10209 | KIAA1175 phosphofurin acidic cluster sorting protein 1 - HPRD 9695949|11331585
PLAU ATF | UPA | URK | UROKINASE | u-PA plasminogen activator, urokinase - HPRD 9566979
PLAUR CD87 | UPAR | URKR plasminogen activator, urokinase receptor Reconstituted Complex BioGRID 9566979
USF1 FCHL | FCHL1 | HYPLIP1 | MLTF | MLTFI | UEF | bHLHb11 upstream transcription factor 1 An unspecified isoform of USF1 interacts with IGF2R promoter. BIND 12857727
USF2 FIP | bHLHb12 upstream transcription factor 2, c-fos interacting An unspecified isoform of USF2 interacts with IGF2R promoter. BIND 12857727
WISP2 CCN5 | CT58 | CTGF-L WNT1 inducible signaling pathway protein 2 - HPRD 10358067


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG LYSOSOME 121 83 All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING 129 74 All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 60 31 All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 53 27 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP 126 72 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 115 78 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 65 UP 22 13 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 150 93 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176 111 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP 110 71 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293 193 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT UP 78 48 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 58 43 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 71 48 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202 115 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C3 14 10 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 90 71 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7 90 52 All SZGR 2.0 genes in this pathway
JEPSEN SMRT TARGETS 33 23 All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN 78 44 All SZGR 2.0 genes in this pathway
POS RESPONSE TO HISTAMINE UP 13 10 All SZGR 2.0 genes in this pathway
POS HISTAMINE RESPONSE NETWORK 32 22 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 147 83 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS 80 56 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER EARLY RECURRENCE DN 7 6 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 115 74 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP 104 67 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157 106 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 DN 17 13 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS DN 27 24 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169 105 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 135 96 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 106 77 All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES 63 47 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 998 1004 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-15/16/195/424/497 318 324 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-185 372 378 m8 hsa-miR-185brain UGGAGAGAAAGGCAGUUC
miR-19 1005 1012 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-204/211 114 121 1A,m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-224 1017 1024 1A,m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p 177 184 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-381 1270 1276 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-542-5p 654 660 1A hsa-miR-542-5p UCGGGGAUCAUCAUGUCACGAG