Gene Page:IHH

概括?
基因 3549
Symbol IHH
Synonyms BDA1|HHG2
Description indian hedgehog
Reference MIM:600726|HGNC:HGNC:5956|Ensembl:ENSG00000163501|HPRD:02839|Vega:OTTHUMG00000154631
Gene type protein-coding
Map location 2q33-q35
Pascal p-value 0.04
Fetal beta 0.016
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cerebellum

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00916
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01016

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08957652 2 219925251 IHH 2.3E-5 -0.229 0.017 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26所示postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005113 patched binding NAS -
GO:0005515 protein binding IEA -
GO:0016740 transferase activity IEA -
GO:0008233 peptidase activity IEA -
GO:0015485 cholesterol binding NAS -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0001569 patterning of blood vessels IEA -
GO:0001501 skeletal system development IEA -
GO:0001649 osteoblast differentiation IEA -
GO:0006508 proteolysis IEA -
GO:0007267 cell-cell signaling NAS -
GO:0008284 positive regulation of cell proliferation IEA -
GO:0048469 cell maturation IEA -
GO:0007389 pattern specification process IEA -
GO:0016539 intein-mediated protein splicing IEA -
GO:0045596 negative regulation of cell differentiation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region NAS -
GO:0005886 plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG HEDGEHOG SIGNALING PATHWAY 56 42 该途径中的所有SZGR 2.0基因
PID HEDGEHOG 2PATHWAY 22 17 该途径中的所有SZGR 2.0基因
REACTOME SIGNALING BY GPCR 920 449 该途径中的所有SZGR 2.0基因
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 88 58 该途径中的所有SZGR 2.0基因
REACTOME GPCR LIGAND BINDING 408 246 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 该途径中的所有SZGR 2.0基因
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
PEREZ TP53 AND TP63 TARGETS 205 145 该途径中的所有SZGR 2.0基因
RASHI RESPONSE TO IONIZING RADIATION 3 48 31 该途径中的所有SZGR 2.0基因
SCHLESINGER METHYLATED IN COLON CANCER 10 7 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 该途径中的所有SZGR 2.0基因
FIRESTEIN PROLIFERATION 175 125 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 59 35 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 8 49 36 该途径中的所有SZGR 2.0基因
MARTENS TRETINOIN RESPONSE UP 857 456 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS UP 504 321 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS DN 882 538 该途径中的所有SZGR 2.0基因
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 该途径中的所有SZGR 2.0基因
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289 184 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 该途径中的所有SZGR 2.0基因
NABA SECRETED FACTORS 344 197 该途径中的所有SZGR 2.0基因
NABA MATRISOME ASSOCIATED 753 411 该途径中的所有SZGR 2.0基因
NABA MATRISOME 1028 559 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 378 384 m8 HSA-MIR-103brain AGCAGCAUUGUACAGGGCUAUGA
HSA-MIR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-122 503 509 m8 hsa-miR-122a UGGAGUGUGACAAUGGUGUUUGU
miR-15/16/195/424/497 379 386 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-150 717 723 1A hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-23 565 571 m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-323 565 571 1A hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-503 380 386 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG