SZGR2 - Beplay体育中心

Summary？

基因	355
象征	fas
同义词	alps1a \| apo-1 \| apt1 \| cd95 \| fas1 \| fastm \| tnfrsf6
描述	Fas cell surface death receptor
Reference	MIM：134637\|HGNC:HGNC:11920\|Ensembl：ENSG00000026103\|HPRD:00609\|Vega:OTTHUMG00000018701
基因类型	蛋白质编码
Map location	10q24.1
Pascal P值	0.654
主持人	Anterior cingulate cortex BA24 Caudate basal ganglia 皮质 Frontal Cortex BA9 海马伏隔核基底神经节梭子基底神经节元

基因in Data Sources

基因set name	基因组方法	描述	信息
简历：PGCNP	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
表达	元-analysis of gene expression	p价值：2.86
Literature	High-throughput literature-search	与精神分裂症的关键字相同：精神分裂症，精神分裂症，精神分裂症，精神分裂症，精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0203

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	位置	主持人	Gene Entrez ID	pvalue	TSS距离	EQTL类型
RS7082101	10	90741615	fas	ENSG00000026103.15	3.476e-11	-8799	gtex_brain_ba24
RS7069841	10	90741955	fas	ENSG00000026103.15	3.456e-11	-8459	gtex_brain_ba24
rs11202918	10	90742008	fas	ENSG00000026103.15	7.81E-7	-8406	gtex_brain_ba24
RS7082720	10	90742049	fas	ENSG00000026103.15	3.483e-11	-8365	gtex_brain_ba24
RS7910660	10	90743197	fas	ENSG00000026103.15	3.442E-11	-7217	gtex_brain_ba24
rs7910825	10	90743341	fas	ENSG00000026103.15	3.442E-11	-7073	gtex_brain_ba24
RS3903454	10	90743434	fas	ENSG00000026103.15	8.059E-7	-6980	gtex_brain_ba24
rs1926201	10	90746360	fas	ENSG00000026103.15	3.442E-11	-4054	gtex_brain_ba24
rs1926200	10	90746533	fas	ENSG00000026103.15	3.442E-11	-3881	gtex_brain_ba24
RS1926199	10	90746660	fas	ENSG00000026103.15	3.442E-11	-3754	gtex_brain_ba24
RS4934434	10	90747169	fas	ENSG00000026103.15	1.052E-6	-3245	gtex_brain_ba24
RS7914490	10	90747447	fas	ENSG00000026103.15	3.434e-11	-2967	gtex_brain_ba24
RS3758485	10	90747847	fas	ENSG00000026103.15	1.302E-6	-2567	gtex_brain_ba24
RS978522	10	90748338	fas	ENSG00000026103.15	1.565E-6	-2076	gtex_brain_ba24
RS1926197	10	90748626	fas	ENSG00000026103.15	3.43e-11	-1788	gtex_brain_ba24
RS1800682	10	90749963	fas	ENSG00000026103.15	3.441e-11	-451	gtex_brain_ba24
RS12775501	10	90750909	fas	ENSG00000026103.15	3.337E-8	495	gtex_brain_ba24
RS3740286	10	90751340	fas	ENSG00000026103.15	2.97E-8	926	gtex_brain_ba24
rs1324551	10	90751516	fas	ENSG00000026103.15	6.852e-13	1102	gtex_brain_ba24
RS6586163	10	90752018	fas	ENSG00000026103.15	1.116e-12	1604	gtex_brain_ba24
RS6586164	10	90752031	fas	ENSG00000026103.15	1.116e-12	1617年	gtex_brain_ba24
RS3824730	10	90752128	fas	ENSG00000026103.15	2.887E-8	1714	gtex_brain_ba24
rs3824729	10	90752616	fas	ENSG00000026103.15	1.116e-12	2202	gtex_brain_ba24
rs10887877	10	90753038	fas	ENSG00000026103.15	1.116e-12	2624	gtex_brain_ba24
rs12359362	10	90753145	fas	ENSG00000026103.15	2.788e-8	2731	gtex_brain_ba24
rs7097572	10	90753260	fas	ENSG00000026103.15	1.116e-12	2846	gtex_brain_ba24
rs5786849	10	90753549	fas	ENSG00000026103.15	1.116e-12	3135	gtex_brain_ba24
RS1926196	10	90753748	fas	ENSG00000026103.15	1.116e-12	3334	gtex_brain_ba24
RS1926195	10	90753758	fas	ENSG00000026103.15	1.249e-12	3344	gtex_brain_ba24
RS2031610	10	90754487	fas	ENSG00000026103.15	2.724E-8	4073	gtex_brain_ba24
rs7897395	10	90754607	fas	ENSG00000026103.15	2.718E-12	4193	gtex_brain_ba24
rs7069061	10	90754909	fas	ENSG00000026103.15	1.271E-12	4495	gtex_brain_ba24
rs7072828	10	90754953	fas	ENSG00000026103.15	1.306e-12	4539	gtex_brain_ba24
RS6586165	10	90755056	fas	ENSG00000026103.15	1.372E-12	4642	gtex_brain_ba24
RS6586166	10	90756065	fas	ENSG00000026103.15	4.382E-12	5651	gtex_brain_ba24
RS6586167	10	90756146	fas	ENSG00000026103.15	4.729e-12	5732	gtex_brain_ba24
rs2147420	10	90759613	fas	ENSG00000026103.15	1.403E-8	9199	gtex_brain_ba24
rs4406737	10	90759724	fas	ENSG00000026103.15	1.403E-8	9310	gtex_brain_ba24
RS2148287	10	90759772	fas	ENSG00000026103.15	2.705E-8	9358	gtex_brain_ba24
rs4406738	10	90760012	fas	ENSG00000026103.15	1.403E-8	9598	gtex_brain_ba24
rs2182408	10	90760107	fas	ENSG00000026103.15	1.408E-8	9693	gtex_brain_ba24
rs1926194	10	90760318	fas	ENSG00000026103.15	8.28E-9	9904	gtex_brain_ba24
rs1926193	10	90760606	fas	ENSG00000026103.15	9.36e-9	10192	gtex_brain_ba24
rs1926192	10	90760620	fas	ENSG00000026103.15	8.28E-9	10206	gtex_brain_ba24
rs9658720	10	90760669	fas	ENSG00000026103.15	8.527E-9	10255	gtex_brain_ba24
RS7069750	10	90762376	fas	ENSG00000026103.15	1.181E-8	11962	gtex_brain_ba24
RS9658742	10	90764891	fas	ENSG00000026103.15	2.159E-7	14477	gtex_brain_ba24
RS7901656	10	90766213	fas	ENSG00000026103.15	1.323E-6	15799	gtex_brain_ba24
RS7082101	10	90741615	fas	ENSG00000026103.15	6.281E-9	-8799	gtex_brain_putamen_basal
RS7069841	10	90741955	fas	ENSG00000026103.15	6.269E-9	-8459	gtex_brain_putamen_basal
rs11202918	10	90742008	fas	ENSG00000026103.15	6.534E-7	-8406	gtex_brain_putamen_basal
RS7082720	10	90742049	fas	ENSG00000026103.15	6.259E-9	-8365	gtex_brain_putamen_basal
RS7910660	10	90743197	fas	ENSG00000026103.15	6.247E-9	-7217	gtex_brain_putamen_basal
rs7910825	10	90743341	fas	ENSG00000026103.15	6.236E-9	-7073	gtex_brain_putamen_basal
RS3903454	10	90743434	fas	ENSG00000026103.15	6.643E-7	-6980	gtex_brain_putamen_basal
rs1926201	10	90746360	fas	ENSG00000026103.15	6.261E-9	-4054	gtex_brain_putamen_basal
rs1926200	10	90746533	fas	ENSG00000026103.15	6.261E-9	-3881	gtex_brain_putamen_basal
RS1926199	10	90746660	fas	ENSG00000026103.15	6.261E-9	-3754	gtex_brain_putamen_basal
RS4934434	10	90747169	fas	ENSG00000026103.15	6.639E-7	-3245	gtex_brain_putamen_basal
RS7914490	10	90747447	fas	ENSG00000026103.15	6.252E-9	-2967	gtex_brain_putamen_basal
RS3758485	10	90747847	fas	ENSG00000026103.15	6.635E-7	-2567	gtex_brain_putamen_basal
RS978522	10	90748338	fas	ENSG00000026103.15	6.631E-7	-2076	gtex_brain_putamen_basal
RS1926197	10	90748626	fas	ENSG00000026103.15	6.251E-9	-1788	gtex_brain_putamen_basal
RS1800682	10	90749963	fas	ENSG00000026103.15	6.24e-9	-451	gtex_brain_putamen_basal
RS12775501	10	90750909	fas	ENSG00000026103.15	3.131E-13	495	gtex_brain_putamen_basal
RS3740286	10	90751340	fas	ENSG00000026103.15	2.882E-13	926	gtex_brain_putamen_basal
rs4064	10	90751380	fas	ENSG00000026103.15	1.069E-6	966	gtex_brain_putamen_basal
rs1324551	10	90751516	fas	ENSG00000026103.15	1.886E-14	1102	gtex_brain_putamen_basal
RS10509561	10	90751912	fas	ENSG00000026103.15	1.071E-6	1498	gtex_brain_putamen_basal
RS6586163	10	90752018	fas	ENSG00000026103.15	1.621E-14	1604	gtex_brain_putamen_basal
RS6586164	10	90752031	fas	ENSG00000026103.15	1.621E-14	1617年	gtex_brain_putamen_basal
RS3824730	10	90752128	fas	ENSG00000026103.15	2.779E-13	1714	gtex_brain_putamen_basal
rs3824729	10	90752616	fas	ENSG00000026103.15	1.589E-14	2202	gtex_brain_putamen_basal
rs10887877	10	90753038	fas	ENSG00000026103.15	1.562E-14	2624	gtex_brain_putamen_basal
rs12359362	10	90753145	fas	ENSG00000026103.15	2.675E-13	2731	gtex_brain_putamen_basal
rs7097572	10	90753260	fas	ENSG00000026103.15	1.546E-14	2846	gtex_brain_putamen_basal
rs5786849	10	90753549	fas	ENSG00000026103.15	1.531E-14	3135	gtex_brain_putamen_basal
RS1926196	10	90753748	fas	ENSG00000026103.15	1.462E-15	3334	gtex_brain_putamen_basal
RS1926195	10	90753758	fas	ENSG00000026103.15	1.535E-14	3344	gtex_brain_putamen_basal
RS2031610	10	90754487	fas	ENSG00000026103.15	2.64E-13	4073	gtex_brain_putamen_basal
rs7897395	10	90754607	fas	ENSG00000026103.15	3.698e-14	4193	gtex_brain_putamen_basal
rs7069061	10	90754909	fas	ENSG00000026103.15	1.115E-14	4495	gtex_brain_putamen_basal
rs7072828	10	90754953	fas	ENSG00000026103.15	1.725E-14	4539	gtex_brain_putamen_basal
RS6586165	10	90755056	fas	ENSG00000026103.15	1.64e-14	4642	gtex_brain_putamen_basal
rs9658686	10	90755600	fas	ENSG00000026103.15	1.235E-6	5186	gtex_brain_putamen_basal
RS6586166	10	90756065	fas	ENSG00000026103.15	2.043E-14	5651	gtex_brain_putamen_basal
RS6586167	10	90756146	fas	ENSG00000026103.15	2.088E-14	5732	gtex_brain_putamen_basal
rs1571011	10	90757787	fas	ENSG00000026103.15	4.651E-9	7373	gtex_brain_putamen_basal
rs1571013	10	90758349	fas	ENSG00000026103.15	4.704E-9	7935	gtex_brain_putamen_basal
RS7911752	10	90758588	fas	ENSG00000026103.15	4.704E-9	8174	gtex_brain_putamen_basal
rs2147420	10	90759613	fas	ENSG00000026103.15	1.581E-10	9199	gtex_brain_putamen_basal
rs4406737	10	90759724	fas	ENSG00000026103.15	1.581E-10	9310	gtex_brain_putamen_basal
RS2148287	10	90759772	fas	ENSG00000026103.15	1.575E-10	9358	gtex_brain_putamen_basal
RS2148286	10	90759924	fas	ENSG00000026103.15	4.704E-9	9510	gtex_brain_putamen_basal
rs4406738	10	90760012	fas	ENSG00000026103.15	8.894E-11	9598	gtex_brain_putamen_basal
rs2182408	10	90760107	fas	ENSG00000026103.15	1.582E-10	9693	gtex_brain_putamen_basal
rs1926194	10	90760318	fas	ENSG00000026103.15	1.339E-10	9904	gtex_brain_putamen_basal
rs1926193	10	90760606	fas	ENSG00000026103.15	1.405E-10	10192	gtex_brain_putamen_basal
rs1926192	10	90760620	fas	ENSG00000026103.15	1.339E-10	10206	gtex_brain_putamen_basal
rs1926191	10	90760651	fas	ENSG00000026103.15	4.386E-9	10237	gtex_brain_putamen_basal
rs9658720	10	90760669	fas	ENSG00000026103.15	2.214e-10	10255	gtex_brain_putamen_basal
RS7069750	10	90762376	fas	ENSG00000026103.15	1.059E-10	11962	gtex_brain_putamen_basal
RS2296603	10	90763127	fas	ENSG00000026103.15	4.702E-9	12713	gtex_brain_putamen_basal
RS9658741	10	90764739	fas	ENSG00000026103.15	1.525E-8	14325	gtex_brain_putamen_basal
RS9658742	10	90764891	fas	ENSG00000026103.15	7.475E-10	14477	gtex_brain_putamen_basal
RS7901656	10	90766213	fas	ENSG00000026103.15	9.08e-10	15799	gtex_brain_putamen_basal
RS2031612	10	90766980	fas	ENSG00000026103.15	7.849e-8	16566	gtex_brain_putamen_basal
RS7910435	10	90768240	fas	ENSG00000026103.15	3.392E-8	17826	gtex_brain_putamen_basal
RS3781202	10	90769464	fas	ENSG00000026103.15	3.424E-8	19050	gtex_brain_putamen_basal
rs397729759	10	90770084	fas	ENSG00000026103.15	1.656E-8	19670	gtex_brain_putamen_basal
rs200489672	10	90770087	fas	ENSG00000026103.15	2.763E-8	19673	gtex_brain_putamen_basal
RS2296600	10	90770439	fas	ENSG00000026103.15	7.876E-8	20025	gtex_brain_putamen_basal
RS3752986	10	90772781	fas	ENSG00000026103.15	3.424E-8	22367	gtex_brain_putamen_basal
RS3752985	10	90772834	fas	ENSG00000026103.15	1.629E-7	22420	gtex_brain_putamen_basal
rs1571019	10	90773303	fas	ENSG00000026103.15	1.178E-7	22889	gtex_brain_putamen_basal
RS1977389	10	90773494	fas	ENSG00000026103.15	7.876E-8	23080	gtex_brain_putamen_basal
rs2862833	10	90775629	fas	ENSG00000026103.15	1.629E-7	25215	gtex_brain_putamen_basal
rs35150762	10	90777624	fas	ENSG00000026103.15	1.629E-7	27210	gtex_brain_putamen_basal
rs1810763	10	90778829	fas	ENSG00000026103.15	1.629E-7	28415	gtex_brain_putamen_basal
rs913043	10	90778967	fas	ENSG00000026103.15	3.424E-8	28553	gtex_brain_putamen_basal
RS7096473	10	90780214	fas	ENSG00000026103.15	7.855e-8	29800	gtex_brain_putamen_basal
RS7089558	10	90781152	fas	ENSG00000026103.15	1.49E-7	30738	gtex_brain_putamen_basal
rs10887882	10	90782922	fas	ENSG00000026103.15	3.424E-8	32508	gtex_brain_putamen_basal
rs10887883	10	90782973	fas	ENSG00000026103.15	3.424E-8	32559	gtex_brain_putamen_basal
rs12775232	10	90784418	fas	ENSG00000026103.15	7.988e-8	34004	gtex_brain_putamen_basal
rs7095466	10	90784755	fas	ENSG00000026103.15	3.508E-8	34341	gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
FAM188B	0.94	0.74
GFAP	0.83	0.89
pLIN	0.71	0.75
RASL12	0.70	0.77
ITGB4	0.67	0.79
EFEMP1	0.67	0.79
METTL7B	0.65	0.68
ACSM5	0.64	0.63
NUPR1	0.64	0.77
STK19P	0.63	0.59

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
STMN1	-0.36	-0.63
pLEKHO1	-0.36	-0.61
ZBTB8A	-0.35	-0.62
nkiras2	-0.35	-0.62
KIAA1949	-0.35	-0.58
mpp3	-0.34	-0.61
ZNF821	-0.34	-0.60
TUBB2B	-0.34	-0.58
DUSP12	-0.34	-0.62
BZW2	-0.34	-0.64

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0004888	跨膜受体活性	IEA		-
去：0005515	蛋白质结合	IEA		-
GO:0042802	identical protein binding	IPI		7536190
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006461	protein complex assembly	TAS		10875918
去：0007165	信号转导	IEA		-
去：0007165	信号转导	TAS		9360929
去：0008633	activation of pro-apoptotic gene products	经验		14644197
GO:0006955	immune response	IEA		-
GO:0006916	抗凋亡	TAS		7510905
GO:0006915	凋亡	IEA		-
去：0008624	induction of apoptosis by extracellular signals	经验		11048727
GO：0042981	调节凋亡	nas		7533181
细胞分量	去学期	证据	神经关键字	PubMed ID
GO:0005829	cytosol	nas		7533181
去：0005576	细胞外区域	IEA		-
GO:0005625	可溶性部分	TAS		7510905
去：0016020	membrane	IEA		-
GO：0016021	integral to membrane	IEA		-
GO:0005886	plasma membrane	经验		7530336\|7536190\|8521815 \|8681376\|9721089
GO:0005886	plasma membrane	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
Arhgdia	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	共纯化	Biogrid	15659383
出价	FP497 \|MGC15319 \|MGC42355	BH3 interacting domain death agonist	共纯化	Biogrid	15659383
btk	AGMX1 \|在\|ATK \|bpk \|IMD1 \|MGC126261 \|MGC126262 \|PSCTK1 \|XLA	Bruton agammaglobulinemia tyrosine kinase	-	HPRD	9751072
C14orf1	ERG28 \|Net51	染色体14开放阅读框1	Two-hybrid	Biogrid	16169070
C1orf103	FLJ11269 \| RIF1 \| RP11-96K19.1	染色体1开放阅读框103	Two-hybrid	Biogrid	16169070
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	9045686
CASP8	ALPS2B \|cap4 \|弗里斯\|FLJ17672 \|马赫\|MCH5 \|MGC78473	caspase 8, apoptosis-related cysteine peptidase	-	HPRD	11101867
CASP8	ALPS2B \|cap4 \|弗里斯\|FLJ17672 \|马赫\|MCH5 \|MGC78473	caspase 8, apoptosis-related cysteine peptidase	亲和力捕获 - 韦斯特恩共纯化	Biogrid	9208847\|9325248 \|15659383
CASP8AP2	CED-4 \|闪光灯\|FLJ11208 \|KIAA1315 \|RIP25	caspase 8相关蛋白2	-	HPRD,BioGRID	10235259
Cflar	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8和FADD样细胞凋亡调节剂	亲和力捕获 - 韦斯特恩	Biogrid	9208847\|9325248
CRMP1	dpysl1 \|DRP-1 \|DRP1	折叠蛋白反应介质蛋白1	Two-hybrid	Biogrid	16169070
CTNNB1	ctnnb \|DKFZP686D02253 \|FLJ25606 \|FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	CTNNB1（β-catenin）与FAS启动子相互作用。	BIND	15829968
daxx	Bing2 \|DAP6 \|EAP1 \|MGC126245 \|MGC126246	death-domain associated protein	重构的复合物	Biogrid	11483955
daxx	Bing2 \|DAP6 \|EAP1 \|MGC126245 \|MGC126246	death-domain associated protein	-	HPRD	9215629\|11193028
EEF1A1	CCS-3 \|CCS3 \|EEF-1 \|EEF1A \|ef-tu \|EF1A \|FLJ25721 \|graf-1ef \|HNGC：16303 \|leng7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	真核翻译伸长因子1 alpha 1	Two-hybrid	Biogrid	16169070
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	埃兹林	共纯化	Biogrid	15659383
fadd	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	FAS与FADD相互作用。	BIND	15383280
fadd	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	FAS的未指定同工型与FADD相互作用。	BIND	15665818
fadd	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	-	HPRD,BioGRID	7538907\|8967952
fadd	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	-	HPRD	7536190\|7538907 \|8967952\|7538907\|8967952
FAF1	CGI-03 \|FLJ37524 \|HFAF1S \|ubxd12 \|ubxn3a \|HFAF1	Fas (TNFRSF6) associated factor 1	-	HPRD,BioGRID	8524870\|9740801
Faim2	KIAA0950 \| LFG \| NGP35 \| NMP35 \| TMBIM2	Fas apoptotic inhibitory molecule 2	-	HPRD,BioGRID	10535980
fas	Alps1a \|apo-1 \|apt1 \|CD95 \|fas1 \|FastM \|TNFRSF6	FAS（TNF受体超家族，成员6）	Two-hybrid	Biogrid	7538908
faslg	APT1LG1 \|CD178 \|CD95L \|fasl \|TNFSF6	FAS配体（TNF超家族，成员6）	-	HPRD,BioGRID	9126929\|9228058
FBF1	Alb \| FBF-1 \| FLJ00103	Fas (TNFRSF6) binding factor 1	-	HPRD,BioGRID	10978533
FEM1B	DKFZp451E0710 \| FIAA	FEM-1同源物B（秀丽隐杆线虫）	-	HPRD	10542291
Fyn	MGC45350 \| SLK \| SYN	Fynoncogene related to SRC, FGR, YES	-	HPRD,BioGRID	8626376
HIPK3	dyrk6 \|Fist3 \|pky \|Yak1	同源域相互作用蛋白激酶3	-	HPRD,BioGRID	11034606
Kat5	esa1 \|htatip \|htatip1 \|plip \|提示\|TIP60 \|CPLA2	K（赖氨酸）乙酰转移酶5	HTATIP (Tip60) interacts with the FAS promoter.	BIND	15829968
LCK	yt16 \|p56lck \|pp58lck	淋巴细胞特异性蛋白酪氨酸激酶	-	HPRD,BioGRID	8864141
MAPK8	jnk \|JNK1 \|JNK1A2 \|JNK21B1/2 \|prkm8 \|SAPK1	有丝分裂原激活的蛋白激酶8	共纯化	Biogrid	15659383
MSN	-	moesin	共纯化	Biogrid	15659383
NOL3	弧\|卡2 \|MYC \|myp \|nop \|NOP30	核仁蛋白3（带卡结构域的凋亡抑制剂）	ARC interacts with an unspecified isoform of Fas.	BIND	15383280
NOL3	弧\|卡2 \|MYC \|myp \|nop \|NOP30	核仁蛋白3（带卡结构域的凋亡抑制剂）	表型抑制	Biogrid	9560245
PDCD6	ALG-2 \|FLJ46208 \|MGC111017 \|MGC119050 \|MGC9123 \|PEF1B	程序性细胞死亡6	-	HPRD,BioGRID	11606059
PTPN13	DKFZP686J1497 \|FAP-1 \|PNP1 \|PTP-BAS \|ptp-bl \|ptp1e \|ptpl1 \|ptple	蛋白酪氨酸磷酸酶，非受体13型（APO-1/CD95（FAS）相关磷酸酶）	-	HPRD	7536343\|9079683
Rhoa	ARH12 \|arha \|Rho12 \|RHOH12	ras homolog gene family, member A	共纯化	Biogrid	15659383
RIPK1	FLJ39204 \|RIP \|RIP1	受体（TNFRSF） - 互动丝氨酸 - 硫代激酶1	-	HPRD,BioGRID	7538908\|9740801
ruvbl2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	RUVBL2（Reptin）与FAS启动子相互作用。	BIND	15829968
SUMO1	DAP-1 \|GMP1 \|OFC10 \|pic1 \|senp2 \|SMT3 \|SMT3C \|SMT3H3 \|Sumo-1 \|UBL1	MIF的SMT3抑制器两个3同源物1（S. cerevisiae）	重构的复合物 Two-hybrid	Biogrid	8906799\|11112409
SUMO1	DAP-1 \|GMP1 \|OFC10 \|pic1 \|senp2 \|SMT3 \|SMT3C \|SMT3H3 \|Sumo-1 \|UBL1	MIF的SMT3抑制器两个3同源物1（S. cerevisiae）	FAS与Sentrin互动。	BIND	11112409
SUMO1	DAP-1 \|GMP1 \|OFC10 \|pic1 \|senp2 \|SMT3 \|SMT3C \|SMT3H3 \|Sumo-1 \|UBL1	MIF的SMT3抑制器两个3同源物1（S. cerevisiae）	-	HPRD	8906799\|9740801
TNFRSF10B	CD262 \|DR5 \|杀手\|杀手/DR5 \|trail-r2 \|TRAILR2 \|技巧2 \|Trick2a \|trick2b \|技巧\| ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	共纯化	Biogrid	15659383
tnfrsf1a	CD120A \|FPF \|MGC19588 \|TBP1 \|TNF-R \|tnf-r-i \|TNF-R55 \|tnfar \|TNFR1 \|TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	肿瘤坏死因子受体超家族，成员1a	共纯化	Biogrid	15659383
TNFSF12-TNFSF13	TWE-PRIL	TNFSF12-TNFSF13读取笔录	-	HPRD	10706119
TNFSF13	四月\|CD256 \|高2 \|trdl-1 \|UNQ383/PRO715 \|配体	肿瘤坏死因子（配体）超家族，成员13	重构的复合物	Biogrid	10706119
TP63	AIS \| B(p51A) \| B(p51B) \| EEC3 \| KET \| LMS \| NBP \| OFC8 \| RHS \| SHFM4 \| TP53CP \| TP53L \| TP73L \| p40 \| p51 \| p53CP \| p63 \| p73H \| p73L	tumor protein p63	p63 interacts with CD95.	BIND	15944736
传统	HS.89862 \|MGC11078	通过死亡域与TNFRSF1A相关	-	HPRD	8681376\|9427646
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-	HPRD,BioGRID	9257699

Section V. Pathway annotation

pathway name	路径大小	# SZGR 2.0 genes in pathway	信息
kegg mapk信号通路	267	205	All SZGR 2.0 genes in this pathway
KEGG细胞因子细胞因子受体相互作用	267	161	All SZGR 2.0 genes in this pathway
KEGG P53信号通路	69	45	All SZGR 2.0 genes in this pathway
kegg凋亡	88	62	All SZGR 2.0 genes in this pathway
kegg天然杀伤细胞介导的细胞毒性	137	92	All SZGR 2.0 genes in this pathway
KEGG I型糖尿病	44	38	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE	53	49	All SZGR 2.0 genes in this pathway
KEGG同种异体拒绝	38	34	All SZGR 2.0 genes in this pathway
KEGG移植与宿主疾病	42	31	All SZGR 2.0 genes in this pathway
Biocarta Asbcell途径	12	11	All SZGR 2.0 genes in this pathway
Biocarta CTL途径	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY	30	22	All SZGR 2.0 genes in this pathway
生物核心凋亡途径	11	8	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY	38	26	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
Biocarta PML途径	17	12	All SZGR 2.0 genes in this pathway
Biocarta HSP27途径	15	11	All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE	19	13	All SZGR 2.0 genes in this pathway
SA FAS SIGNALING	9	5	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
PID P73Pathway	79	59	All SZGR 2.0 genes in this pathway
pID FAS PATHWAY	38	29	All SZGR 2.0 genes in this pathway
pID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
pID HIV NEF PATHWAY	35	26	All SZGR 2.0 genes in this pathway
PID TAP63途径	54	40	All SZGR 2.0 genes in this pathway
REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	13	8	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性	351	230	All SZGR 2.0 genes in this pathway
Sengupta鼻咽癌	294	178	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID UP	25	18	All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS DN	463	290	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病	1382	904	All SZGR 2.0 genes in this pathway
Deurig t细胞促进性白血病DN	320	184	All SZGR 2.0 genes in this pathway
乳腺癌腔与基础DN	455	304	All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN	460	312	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN	186	114	All SZGR 2.0 genes in this pathway
UDayakumar Med1靶向DN	240	171	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP	98	58	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
kokkinakis甲硫氨酸剥夺96小时	117	84	All SZGR 2.0 genes in this pathway
lau凋亡CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
甲状腺癌	443	294	All SZGR 2.0 genes in this pathway
Chiaradonna肿瘤转化KRAS CDC25 DN	51	35	All SZGR 2.0 genes in this pathway
Markey RB1急性LOF DN	228	137	All SZGR 2.0 genes in this pathway
血清剥夺的Graessmann凋亡	552	347	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
GRAESSMANN MC和血清剥夺	211	136	All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
障碍癌复发正常样本	32	21	All SZGR 2.0 genes in this pathway
Kerley对Cisplatin的反应	44	30	All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS UP	23	15	All SZGR 2.0 genes in this pathway
贝克造血STAT3目标	16	12	All SZGR 2.0 genes in this pathway
dutta凋亡通过NFKB	33	25	All SZGR 2.0 genes in this pathway
Rashi对电离辐射6的响应6	84	54	All SZGR 2.0 genes in this pathway
TP53和TP63的Schavolt目标	16	12	All SZGR 2.0 genes in this pathway
dacosta低剂量紫外线通过ERCC3 XPC向上	18	10	All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN	38	31	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络	1442	892	All SZGR 2.0 genes in this pathway
阿尔卡拉凋亡	88	60	All SZGR 2.0 genes in this pathway
通过ELK3 UP总缺氧	209	139	All SZGR 2.0 genes in this pathway
通过ELK3和HIF1A DN的缺氧总缺氧	103	71	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向	1037	673	All SZGR 2.0 genes in this pathway
JEON SMAD6 TARGETS UP	24	15	All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇8	36	28	All SZGR 2.0 genes in this pathway
der ifn alpha响应	74	48	All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS UP	58	40	All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN	309	206	All SZGR 2.0 genes in this pathway
Sasaki成人T细胞白血病	176	122	All SZGR 2.0 genes in this pathway
Magrangeas多发性骨髓瘤Igll vs Iglk	42	24	All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP	71	45	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN	366	238	All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS UP	52	34	All SZGR 2.0 genes in this pathway
亚伯拉罕ALPC与多发性骨髓瘤	26	22	All SZGR 2.0 genes in this pathway
Affar YY1目标	214	133	All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL UP	13	8	All SZGR 2.0 genes in this pathway
卫生部对干扰素beta的反应	71	49	All SZGR 2.0 genes in this pathway
Ongusaha TP53目标	38	23	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
Chuang氧化应激反应向上	28	18	All SZGR 2.0 genes in this pathway
WU HBX目标3	18	11	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
WU HBX TARGETS 1 UP	16	10	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP	95	64	All SZGR 2.0 genes in this pathway
YIH对砷C1的反应	24	14	All SZGR 2.0 genes in this pathway
WU HBX目标2向上	23	13	All SZGR 2.0 genes in this pathway
Han Jnk Singaling DN	39	27	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应	953	554	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应	1011	592	All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定	491	310	All SZGR 2.0 genes in this pathway
促进耐受巨噬细胞DN	409	268	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
Massarweh tamoxifen抗性	578	341	All SZGR 2.0 genes in this pathway
Marzec IL2信号传导DN	36	24	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS UP	43	28	All SZGR 2.0 genes in this pathway
de yy1靶向DN	92	64	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
Qi Plasmacytoma Up	259	185	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP	77	56	All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP	107	67	All SZGR 2.0 genes in this pathway
Schraets MLL靶向	35	21	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
McMurray TP53 HRAS合作响应DN	67	46	All SZGR 2.0 genes in this pathway
Hsiao家政基因	389	245	All SZGR 2.0 genes in this pathway
Boyault肝癌子类G123 DN	51	30	All SZGR 2.0 genes in this pathway
清肝癌子类CTNNB1 UP	176	110	All SZGR 2.0 genes in this pathway
开罗肝母细胞瘤课程DN	210	141	All SZGR 2.0 genes in this pathway
由MYC DN监管	253	192	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3	445	257	All SZGR 2.0 genes in this pathway
Hoelzel NF1靶向	139	93	All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应	549	316	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
Katsanou Elavl1靶向	169	105	All SZGR 2.0 genes in this pathway
Plasari TGFB1通过NFIC 10小时信号传导	54	38	All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A	770	480	All SZGR 2.0 genes in this pathway
林乳腺干细胞向上	489	314	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN	99	74	All SZGR 2.0 genes in this pathway
Smirnov对IR 2小时的回应	53	33	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP	166	97	All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP	110	68	All SZGR 2.0 genes in this pathway
WARTERS对IR皮肤的反应	83	44	All SZGR 2.0 genes in this pathway
WARTERS红外响应5GY	47	23	All SZGR 2.0 genes in this pathway

基因page:fas