Gene Page:IL6

Summary？
GeneID 3569
象征 IL6
Synonyms BSF-2 | BSF2 | CDF | HGF | HSF | IFN-BETA-2 | IFNB2 | IL-6
Description interleukin 6
Reference MIM：147620|HGNC：HGNC：6018|Ensembl:ENSG00000136244|HPRD:00970|Vega:OTTHUMG00000023178
基因类型 蛋白质编码
Map location 7p21
Pascal p-value 0.042
胎儿β -0.71

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症 点击显示详细信息

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
Rab26 0.71 0.66
Thy1 0.70 0.67
BDH1 0.70 0.70
PNPO 0.69 0.68
SLC25A23 0.69 0.66
Stat6 0.68 0.71
agmat 0.68 0.68
PDK2 0.68 0.69
CYP46A1 0.67 0.69
GLS2 0.67 0.64
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KIAA1949 -0.50 -0.44
tubb2b -0.49 -0.49
SH2B2 -0.47 -0.54
ZNF311 -0.47 -0.42
MYCN -0.47 -0.35
AF186192.1 -0.47 -0.45
AC004017.1 -0.47 -0.41
ZNF551 -0.47 -0.39
AL033532.1 -0.47 -0.40
ZNF193 -0.46 -0.41

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005125 cytokine activity IEA -
去：0005138 白介素6受体结合 nas 1883960
去：0005515 蛋白质结合 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0001781 neutrophil apoptosis IDA 7595060
GO:0007267 细胞细胞信号传导 nas 1883960
GO:0007166 cell surface receptor linked signal transduction TAS 10925276
GO:0008284 positive regulation of cell proliferation TAS 2829354
GO:0008285 negative regulation of cell proliferation TAS 3023045
去：0006959 humoral immune response TAS 2829354
去：0006954 inflammatory response IDA 10443688
去：0006953 急性期反应 IEA -
GO:0043066 negative regulation of apoptosis IDA 7595060
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 7508917
GO：0042832 defense response to protozoan IEA -
GO：0043410 MAPKKK级联的积极调节 IDA 7508917
GO:0045630 t-助手2细胞分化的正调控 IEA -
GO：0045944 RNA聚合酶II启动子的转录阳性调节 IDA 7508917
GO:0045727 positive regulation of translation IDA 16732314
GO:0046888 激素分泌的阴性调节 IEA -
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA 7508917
GO：0045079 negative regulation of chemokine biosynthetic process ISS -
GO：0051384 对糖皮质激素刺激的反应 IDA 10443688
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 nas 1883960|14718574
去：0005615 extracellular space TAS 10925276

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
Kegg Toll像受体信号通路 102 88 All SZGR 2.0 genes in this pathway
kegg点头喜欢受体信号通路 62 47 All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 56 44 All SZGR 2.0 genes in this pathway
kegg jak stat信号通路 155 105 All SZGR 2.0 genes in this pathway
KEGG造血细胞谱系 88 60 All SZGR 2.0 genes in this pathway
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION 48 36 All SZGR 2.0 genes in this pathway
Kegg Prion疾病 35 28 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
KEGG GRAFT VERSUS HOST DISEASE 42 31 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
BIOCARTA LAIR PATHWAY 17 12 All SZGR 2.0 genes in this pathway
生物卡塔尔细胞因子途径 22 16 All SZGR 2.0 genes in this pathway
Biocarta fordam途径 29 24 All SZGR 2.0 genes in this pathway
Biocarta生物途径 15 11 All SZGR 2.0 genes in this pathway
Biocarta IL17途径 17 12 All SZGR 2.0 genes in this pathway
Biocarta IL5途径 10 9 All SZGR 2.0 genes in this pathway
Biocarta IL6途径 22 16 All SZGR 2.0 genes in this pathway
Biocarta IL10途径 17 14 All SZGR 2.0 genes in this pathway
生物卡塔茎途径 15 13 All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY 22 17 All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 33 29 All SZGR 2.0 genes in this pathway
ST STAT3 PATHWAY 11 10 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID IL27途径 26 20 All SZGR 2.0 genes in this pathway
PID FRA路径 37 28 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY 41 32 All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 59 43 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 47 40 All SZGR 2.0 genes in this pathway
PID IL23 PATHWAY 37 30 All SZGR 2.0 genes in this pathway
ILS的Reactome信号传导 107 86 All SZGR 2.0 genes in this pathway
REACTOME IL 6 SIGNALING 11 9 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央DN 634 384 All SZGR 2.0 genes in this pathway
Zerbini对Sulindac的反应 9 6 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 All SZGR 2.0 genes in this pathway
VMYB vs CMYB DN的LIU目标 43 30 All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN 460 312 All SZGR 2.0 genes in this pathway
VECCHI胃癌ADVANCED VS EARLY UP 175 120 All SZGR 2.0 genes in this pathway
胶原蛋白凝胶中的Oswald造血干细胞 233 161 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
kokkinakis蛋氨酸剥夺48小时 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP 120 73 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 118 78 All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS UP 44 34 All SZGR 2.0 genes in this pathway
Streicher LSM1靶向DN 19 13 All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS DN 15 11 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
贝克造血STAT3目标 16 12 All SZGR 2.0 genes in this pathway
DEBOSSCHER NFKB TARGETS REPRESSED BY GLUCOCORTICOIDS 24 18 All SZGR 2.0 genes in this pathway
Hernandez异常有丝分裂由DOCETACEL 2NM上升 81 57 All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA DN 41 33 All SZGR 2.0 genes in this pathway
留置权乳腺癌化生型与导管 83 51 All SZGR 2.0 genes in this pathway
近代缺氧 8 6 All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 32 17 All SZGR 2.0 genes in this pathway
通过ELK3 DN的缺氧总缺氧 156 106 All SZGR 2.0 genes in this pathway
仅通过ELK3的高缺氧 33 18 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
Amit EGF响应40 HELA 42 29 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
Shin B细胞淋巴瘤簇5 18 11 All SZGR 2.0 genes in this pathway
der ifn alpha响应 74 48 All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 102 67 All SZGR 2.0 genes in this pathway
Tenedini Megakaryocyte标记 66 48 All SZGR 2.0 genes in this pathway
lu IL4信号传导 94 56 All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP 71 45 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162 102 All SZGR 2.0 genes in this pathway
Petrova Prox1靶向DN 64 38 All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS DIRECT UP 27 21 All SZGR 2.0 genes in this pathway
KIM HYPOXIA 25 21 All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2 53 34 All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM UP 45 33 All SZGR 2.0 genes in this pathway
WU HBX TARGETS 2 DN 16 11 All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN 64 45 All SZGR 2.0 genes in this pathway
哈里斯缺氧 81 64 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR DN 21 13 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
Lindvall因TERT DN永生 80 56 All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP 67 45 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
Zhu CMV全部 120 89 All SZGR 2.0 genes in this pathway
WU HBX TARGETS 3 DN 13 9 All SZGR 2.0 genes in this pathway
CHEN ETV5 TARGETS SERTOLI 20 10 All SZGR 2.0 genes in this pathway
麦克拉克兰牙齿龋齿DN 245 144 All SZGR 2.0 genes in this pathway
伯顿成年时期峰值2小时 51 36 All SZGR 2.0 genes in this pathway
周TNF信号30分钟 54 36 All SZGR 2.0 genes in this pathway
WU HBX目标1向上 16 10 All SZGR 2.0 genes in this pathway
伯顿成生成1 33 24 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 123 75 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1 67 41 All SZGR 2.0 genes in this pathway
村上紫外线24小时 20 13 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 47 39 All SZGR 2.0 genes in this pathway
Mahajan对IL1A的回应 81 52 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
Acevedo肝癌，H3K27me3 UP 295 149 All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN 564 326 All SZGR 2.0 genes in this pathway
Smid乳腺癌正常 476 285 All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 73 55 All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
冬季缺氧metagene 242 168 All SZGR 2.0 genes in this pathway
Cromer肿瘤发生 63 36 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 32 20 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS 80 56 All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟A 67 52 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
Hinata NFKB靶向角质形成细胞 91 63 All SZGR 2.0 genes in this pathway
Hinata NFKB靶向成纤维细胞 84 60 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
Han Satb1靶向DN 442 275 All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP 60 42 All SZGR 2.0 genes in this pathway
Croonquist NRA与基质刺激DN 99 65 All SZGR 2.0 genes in this pathway
Lee Liver Cancer Hepatoblast 16 12 All SZGR 2.0 genes in this pathway
尿素对咪喹莫德的反应 23 14 All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 30 19 All SZGR 2.0 genes in this pathway
Gutierrez Waldenstroems大球蛋白血症1 DN 9 7 All SZGR 2.0 genes in this pathway
DORN腺病毒感染12小时DN 33 25 All SZGR 2.0 genes in this pathway
DORN腺病毒感染24小时DN 43 32 All SZGR 2.0 genes in this pathway
DORN腺病毒感染48小时DN 40 29 All SZGR 2.0 genes in this pathway
tian tnf通过NFKB信令 28 21 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
中村脂肪形成早期DN 38 27 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE DN 38 25 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 1HR DN 10 8 All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP 59 44 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 61 44 All SZGR 2.0 genes in this pathway
Hirsch细胞转换签名 242 159 All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老 572 352 All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应 549 316 All SZGR 2.0 genes in this pathway
EWSR1 ETS融合DN的Miyagawa目标 229 135 All SZGR 2.0 genes in this pathway
WANG TNF TARGETS 24 17 All SZGR 2.0 genes in this pathway
Dormoy Elavl1目标 17 10 All SZGR 2.0 genes in this pathway
Winzen通过KHSRP退化 100 70 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向1小时 34 26 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时 199 143 All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289 188 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向DN 784 464 All SZGR 2.0 genes in this pathway
phong TNF靶向 63 43 All SZGR 2.0 genes in this pathway
通过p38部分的phong TNF响应 160 106 All SZGR 2.0 genes in this pathway
Altemeier对LPS具有机械通气的反应 128 81 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
ghandhi直接辐照 110 68 All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导 222 159 All SZGR 2.0 genes in this pathway
Zwang仅通过第二EGF脉冲瞬时向上 1725 838 All SZGR 2.0 genes in this pathway
NABA分泌因素 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
let-7/98 316 322 1A hsa-let-7abrain ugagguaguaguauauaguu
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain ugagguaggagguuauauagu
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain ugagguaguugugugugugcugu
miR-26 210 216 1A HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU