Gene Page:IL12B

概括?
基因 3593
Symbol IL12B
Synonyms CLMF|CLMF2|IL-12B|IMD28|IMD29|NKSF|NKSF2
Description interleukin 12B
Reference MIM:161561|HGNC：HGNC：5970|Ensembl:ENSG00000113302|HPRD:01194|Vega:OTTHUMG00000130307
Gene type protein-coding
Map location 5q33.3
Pascal p-value 0.013
Fetal beta 0.182
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.00459
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4864466 chr4 54403975 IL12B 3593 0.11 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004871 signal transducer activity TAS 9789052
GO:0005125 cytokine activity IDA 1674604
GO:0004896 cytokine receptor activity IEA -
去：0005143 interleukin-12 receptor binding TAS 1674604
GO:0005515 protein binding 新闻学会 10899108
GO:0042164 白介素12α亚基结合 IEA -
GO:0042803 protein homodimerization activity IEA -
GO:0046982 protein heterodimerization activity 新闻学会 1674604
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0002860 积极的监管自然杀手cell mediated cytotoxicity directed against tumor cell target IDA 7903063
GO:0007166 cell surface receptor linked signal transduction IEA -
GO:0007050 cell cycle arrest IDA 16942485
GO:0010224 response to UV-B IDA 8992506
去：0042093 T-helper cell differentiation IDA 1673147
GO:0032816 积极的监管自然杀手cell activation IDA 1674604
GO:0016477 cell migration IDA 7903063
GO:0042104 活化T细胞增殖的阳性调节 IDA 1674604
GO:0032729 positive regulation of interferon-gamma production IDA 1674604
GO：0042088 T-helper 1 type immune response TAS 1673147
GO:0034393 positive regulation of smooth muscle cell apoptosis IDA 16942485
GO:0042035 regulation of cytokine biosynthetic process TAS 1673147
GO:0045785 positive regulation of cell adhesion IDA 7903063
GO:0045078 positive regulation of interferon-gamma biosynthetic process TAS 1673147
GO:0048662 negative regulation of smooth muscle cell proliferation IDA 16942485
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
去：0016020 membrane IEA -
GO:0043514 interleukin-12 complex IDA 1674604

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 该途径中的所有SZGR 2.0基因
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 该途径中的所有SZGR 2.0基因
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 71 51 该途径中的所有SZGR 2.0基因
KEGG JAK STAT SIGNALING PATHWAY 155 105 该途径中的所有SZGR 2.0基因
KEGG TYPE I DIABETES MELLITUS 44 38 该途径中的所有SZGR 2.0基因
KEGG LEISHMANIA INFECTION 72 56 该途径中的所有SZGR 2.0基因
KEGG ALLOGRAFT REJECTION 38 34 该途径中的所有SZGR 2.0基因
BIOCARTA CYTOKINE PATHWAY 22 16 该途径中的所有SZGR 2.0基因
BIOCARTA INFLAM PATHWAY 29 24 该途径中的所有SZGR 2.0基因
BIOCARTA DC PATHWAY 22 20 该途径中的所有SZGR 2.0基因
BIOCARTA IL12 PATHWAY 23 17 该途径中的所有SZGR 2.0基因
BIOCARTA NO2IL12 PATHWAY 17 14 该途径中的所有SZGR 2.0基因
Biocarta NKT途径 29 21 该途径中的所有SZGR 2.0基因
BIOCARTA TH1TH2 PATHWAY 19 14 该途径中的所有SZGR 2.0基因
PID IL27 PATHWAY 26 20 该途径中的所有SZGR 2.0基因
PID IL12 2PATHWAY 63 54 该途径中的所有SZGR 2.0基因
PID IL23 PATHWAY 37 30 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 该途径中的所有SZGR 2.0基因
LIU TARGETS OF VMYB VS CMYB DN 43 30 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 14HR DN 298 200 该途径中的所有SZGR 2.0基因
FOSTER TOLERANT MACROPHAGE DN 409 268 该途径中的所有SZGR 2.0基因
GAURNIER PSMD4 TARGETS 73 55 该途径中的所有SZGR 2.0基因
VILIMAS NOTCH1 TARGETS UP 52 41 该途径中的所有SZGR 2.0基因
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
BUDHU LIVER CANCER METASTASIS DN 7 7 该途径中的所有SZGR 2.0基因
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 30 19 该途径中的所有SZGR 2.0基因
NABA SECRETED FACTORS 344 197 该途径中的所有SZGR 2.0基因
NABA MATRISOME ASSOCIATED 753 411 该途径中的所有SZGR 2.0基因
NABA MATRISOME 1028 559 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-153 362 368 1A hsa-miR-153 Uugcauagucacaaaaguga
miR-448 362 368 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU