Gene Page:IL18

Summary?
GeneID 3606
Symbol IL18
同义词 IGIF|IL-18|IL-1g|IL1F4
Description interleukin 18
Reference MIM:600953|HGNC:HGNC:5986|Ensembl:ENSG00000150782|HPRD:02976|Vega:OTTHUMG00000167006
Gene type protein-coding
Map location 11q23.1
Pascal p-value 0.584
Sherlock p-value 0.016
Fetal beta -0.951

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.006
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DCLK1 0.94 0.95
DLG3 0.94 0.94
MAPRE2 0.94 0.94
YWHAG 0.93 0.95
ARHGEF7 0.93 0.95
ASTN1 0.91 0.92
LARP4B 0.91 0.93
CEP68 0.91 0.93
C11orf41 0.90 0.93
ATRN 0.90 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.71 -0.70
AC021016.1 -0.68 -0.71
TLCD1 -0.67 -0.68
AP002478.3 -0.67 -0.73
AF347015.31 -0.67 -0.69
HIGD1B -0.67 -0.70
ACSF2 -0.67 -0.70
MT-CO2 -0.66 -0.69
CLDN10 -0.66 -0.66
AF347015.21 -0.66 -0.72

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004871 signal transducer activity TAS 8999896
GO:0005149 interleukin-1 receptor binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0030431 sleep ISS Brain (GO term level: 3) 11506998
GO:0001525 angiogenesis IDA 11466388
GO:0007267 cell-cell signaling TAS 9792649
GO:0006955 immune response TAS 8999896
GO:0042095 interferon-gamma biosynthetic process TAS 10227975
GO:0042094 interleukin-2 biosynthetic process TAS 10653850
GO:0042231 interleukin-13 biosynthetic process TAS 10227975
GO:0042253 粒细胞巨噬细胞集落刺激factor biosynthetic process TAS 10653850
GO:0030155 regulation of cell adhesion IDA 11477102
GO:0042104 positive regulation of activated T cell proliferation IDA 8766574|10000000
GO:0042033 chemokine biosynthetic process TAS 11598150
GO:0042088 T-helper 1 type immune response IDA 8766574
GO:0042092 T-helper 2 type immune response TAS 11905033
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region TAS 11598150
GO:0005615 extracellular space IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 62 47 All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 56 44 All SZGR 2.0 genes in this pathway
BIOCARTA CYTOKINE PATHWAY 22 16 All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY 23 17 All SZGR 2.0 genes in this pathway
BIOCARTA NKCELLS PATHWAY 20 13 All SZGR 2.0 genes in this pathway
BIOCARTA TH1TH2 PATHWAY 19 14 All SZGR 2.0 genes in this pathway
PID IL27 PATHWAY 26 20 All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 63 54 All SZGR 2.0 genes in this pathway
PID IL23 PATHWAY 37 30 All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY 17 15 All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 33 29 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205 140 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
KIM RESPONSE TO TSA AND DECITABINE UP 129 73 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 85 54 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR DN 129 84 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN 209 122 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316 190 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 149 84 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F UP 185 119 All SZGR 2.0 genes in this pathway
DEBOSSCHER NFKB TARGETS REPRESSED BY GLUCOCORTICOIDS 24 18 All SZGR 2.0 genes in this pathway
YANAGIHARA ESX1 TARGETS 30 19 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193 112 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN 103 71 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261 155 All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 3 28 23 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 118 66 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 50 35 All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 77 48 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 71 49 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 39 29 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP 67 45 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160 103 All SZGR 2.0 genes in this pathway
GAVIN PDE3B TARGETS 22 15 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 145 93 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 89 56 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 44 30 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G24 28 19 All SZGR 2.0 genes in this pathway
WANG METASTASIS OF BREAST CANCER ESR1 DN 30 18 All SZGR 2.0 genes in this pathway
KAMIKUBO MYELOID CEBPA NETWORK 28 19 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway
ISSAEVA MLL2 TARGETS 62 35 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 110 66 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway