Gene Page:IMPG1

Summary?
GeneID 3617
Symbol IMPG1
Synonyms GP147|IPM150|SPACR|VMD4
Description interphotoreceptor matrix proteoglycan 1
Reference MIM:602870|HGNC:HGNC:6055|Ensembl:ENSG00000112706|HPRD:04186|Vega:OTTHUMG00000015063
Gene type protein-coding
Map location 6q14.2-q15
Pascal p-value 0.575
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg12602851 6 76644222 IMPG1 5.533E-4 0.467 0.049 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GAS1 0.88 0.77
HES6 0.87 0.67
CREB3L4 0.86 0.71
CBX2 0.86 0.79
NXN 0.83 0.77
C21orf45 0.83 0.89
MCM7 0.83 0.74
FOXN4 0.83 0.77
RCOR2 0.82 0.90
PHF21B 0.82 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C5orf53 -0.48 -0.75
AIFM3 -0.47 -0.74
HLA-F -0.47 -0.72
PTH1R -0.46 -0.68
FBXO2 -0.46 -0.56
ALDOC -0.46 -0.66
S100B -0.46 -0.81
LDHD -0.45 -0.58
TINAGL1 -0.45 -0.69
AF347015.27 -0.45 -0.84

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0005201 extracellular matrix structural constituent TAS 9691169
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007601 visual perception TAS 9691169
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005578 proteinaceous extracellular matrix TAS 9691169

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
YAGI AML WITH T 9 11 TRANSLOCATION 130 87 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
NABA PROTEOGLYCANS 35 23 All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275 148 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-181 452 459 1A,m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU