Gene Page:ING1

Summary?
GeneID 3621
Symbol ING1
Synonyms p24ING1c|p33|p33ING1|p33ING1b|p47|p47ING1a
Description inhibitor of growth family member 1
Reference MIM:601566|HGNC:HGNC:6062|Ensembl:ENSG00000153487|HPRD:03337|Vega:OTTHUMG00000017346
Gene type protein-coding
Map location 13q34
Pascal p-value 0.05
Sherlock p-value 0.109
Fetal beta 1.13
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 0
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02550602 13 111366822 ING1 7.62E-8 0.005 1.8E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13- 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC068888.1 0.94 0.88
POLR1D 0.94 0.92
DPH5 0.93 0.93
TINP1 0.92 0.88
IGBP1 0.92 0.91
NPM1 0.92 0.88
CCT2 0.91 0.91
EIF2A 0.91 0.90
RSL1D1 0.91 0.89
TEX10 0.91 0.91
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC9A3R2 -0.61 -0.69
HLA-F -0.59 -0.79
AIFM3 -0.58 -0.78
AL132868.3 -0.57 -0.75
ZBTB47 -0.57 -0.62
APOL1 -0.56 -0.79
FBXO2 -0.56 -0.70
ATP10A -0.56 -0.74
LHPP -0.55 -0.61
APOL3 -0.55 -0.78

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTL6A ACTL6 | Arp4 | BAF53A | INO80K | MGC5382 actin-like 6A Affinity Capture-MS BioGRID 11784859
ARID1A B120 | BAF250 | BAF250a | BM029 | C1orf4 | P270 | SMARCF1 AT rich interactive domain 1A (SWI-like) Affinity Capture-MS BioGRID 11784859
C20orf20 Eaf7 | FLJ10914 | MRG15BP | MRGBP | URCC4 chromosome 20 open reading frame 20 - HPRD 12963728
CREBBP CBP | KAT3A | RSTS CREB binding protein Affinity Capture-Western BioGRID 12015309
DMAP1 DKFZp686L09142 | DNMAP1 | DNMTAP1 | EAF2 | FLJ11543 | KIAA1425 | SWC4 DNA methyltransferase 1 associated protein 1 - HPRD,BioGRID 14665632
EP300 KAT3B | p300 E1A binding protein p300 - HPRD,BioGRID 12015309
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 11784859|12015309
HDAC2 RPD3 | YAF1 histone deacetylase 2 Affinity Capture-MS BioGRID 11784859
HIST2H3A H3/n | H3/o histone cluster 2, H3a Biochemical Activity BioGRID 12015309
HIST4H4 H4/p | MGC24116 集群组蛋白H4 Biochemical Activity BioGRID 12015309
KAT2B CAF | P | P/CAF | PCAF K(lysine) acetyltransferase 2B - HPRD,BioGRID 12015309
PCNA MGC8367 proliferating cell nuclear antigen - HPRD,BioGRID 11682605|12015309
RBBP4 NURF55 | RBAP48 retinoblastoma binding protein 4 Affinity Capture-MS BioGRID 11784859
RBBP7 MGC138867 | MGC138868 | RbAp46 retinoblastoma binding protein 7 Affinity Capture-MS BioGRID 11784859
SAP30 - Sin3A-associated protein, 30kDa - HPRD,BioGRID 11784859
SIN3A DKFZp434K2235 | FLJ90319 | KIAA0700 SIN3 homolog A, transcription regulator (yeast) Affinity Capture-Western BioGRID 11784859
SMARCA4 BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2b 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily a, member 4 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 11784859
SMARCB1 BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily b, member 1 Affinity Capture-MS BioGRID 11784859
SMARCC1 BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily c, member 1 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 11784859
SMARCC2 BAF170 | CRACC2 | Rsc8 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily c, member 2 Affinity Capture-MS BioGRID 11784859
SMARCD1 BAF60A | CRACD1 | Rsc6p 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily d, member 1 Affinity Capture-MS BioGRID 11784859
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 - HPRD,BioGRID 9440695|12208736
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 p53 interacts with ING1b. This interaction was modelled on a demonstrated interaction between p53 from an unspecified species and human ING1b. BIND 12208736
TRRAP FLJ10671 | PAF350/400 | PAF400 | STAF40 | TR-AP | Tra1 transformation/transcription domain-associated protein Affinity Capture-Western BioGRID 12015309


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER DN 54 37 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
SCHWAB TARGETS OF BMYB POLYMORPHIC VARIANTS UP 13 9 All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 77 60 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 100 62 All SZGR 2.0 genes in this pathway
WILLERT WNT SIGNALING 24 13 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP 57 35 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 48 34 All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293 193 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 49 29 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER 50 30 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 125 89 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 All SZGR 2.0 genes in this pathway