SZGR2 - Beplay体育中心

Summary?

基因	3624
Symbol	Inhba
同义词	EDF\|FRP
描述	抑制蛋白βa
参考	MIM：147290\|HGNC:HGNC:6066\|HPRD：00929\|
Gene type	protein-coding
地图位置	7P15-P13
Pascal P值	5.726e-5
eGene	迈尔斯的顺式和跨性别

Gene in Data Sources

Gene set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
go_annotation	Mapping neuro-related keywords to Gene Ontology annotations	与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

EQTL注释

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
RS6687320	chr1	37430362	Inhba	3624	0.08	trans
rs1572945	chr1	58069522	Inhba	3624	0.1	trans
rs12030788	chr1	66768128	Inhba	3624	1.609E-4	trans
rs11807500	chr1	68503525	Inhba	3624	0.06	trans
rs2014805	chr2	175165192	Inhba	3624	0.06	trans
rs7608942	chr2	182820100	Inhba	3624	0.2	trans
rs1014141	chr3	43810759	Inhba	3624	0.1	trans
rs11130012	chr3	43823179	Inhba	3624	0.05	trans
RS7615639	chr3	43852564	Inhba	3624	0.15	trans
rs17044826	chr3	66620522	Inhba	3624	0.1	trans
rs1959283	chr3	159917358	Inhba	3624	0.1	trans
RS614566	chr3	182847389	Inhba	3624	0.08	trans
RS6834153	chr4	8606484	Inhba	3624	0	trans
rs6894161	chr5	91098032	Inhba	3624	0.18	trans
RS17109939	chr5	148694416	Inhba	3624	0.03	trans
rs2056166	chr5	160448661	Inhba	3624	0.16	trans
RS11960742	chr5	173068112	Inhba	3624	0.04	trans
rs226945	chr6	3717178	Inhba	3624	0.09	trans
rs226963	chr6	3724120	Inhba	3624	0.13	trans
snp_a-2046639		0	Inhba	3624	0.01	trans
rs3888778	chr6	30529621	Inhba	3624	0.04	trans
rs2239516	chr6	30578047	Inhba	3624	0.04	trans
RS6904236	chr6	30596134	Inhba	3624	0.06	trans
rs7749235	chr6	30635592	Inhba	3624	0.17	trans
rs6457967	chr6	37002011	Inhba	3624	0.07	trans
rs10484851	chr6	38978770	Inhba	3624	0.11	trans
RS9381009	chr6	40918100	Inhba	3624	0.19	trans
RS887719	chr7	21184272	Inhba	3624	0.1	trans
RS320082	chr7	29105404	Inhba	3624	1.668E-6	trans
RS317720	chr7	29110633	Inhba	3624	3.005e-5	trans
RS317714	chr7	29115553	Inhba	3624	1.575E-7	trans
rs317724	chr7	29120565	Inhba	3624	3.005e-5	trans
rs1419793	chr7	34697630	Inhba	3624	0.03	trans
RS343083	chr7	35571887	Inhba	3624	0.03	trans
rs6942437	chr7	146798442	Inhba	3624	0.06	trans
RS12540961	chr8	9689750	Inhba	3624	0	trans
rs7829733	chr8	9691720	Inhba	3624	2.037E-4	trans
rs7013686	chr8	9715474	Inhba	3624	0.04	trans
RS4242415	chr8	24597175	Inhba	3624	0.05	trans
rs2340775	chr8	29082610	Inhba	3624	0.15	trans
RS16886605	chr8	115894398	Inhba	3624	0.14	trans
rs11203077	Chr10	91097084	Inhba	3624	0	trans
rs10834670	Chr11	25404015	Inhba	3624	0	trans
rs10834671	Chr11	25404269	Inhba	3624	0.01	trans
rs17320769	Chr11	30707634	Inhba	3624	0.08	trans
RS11019015	Chr11	90157517	Inhba	3624	0.03	trans
RS17127472	Chr11	123448587	Inhba	3624	0.04	trans
RS11066476	CHR12	113465366	Inhba	3624	0.01	trans
RS16949584	CHR12	120153747	Inhba	3624	0.19	trans
RS4497566	CHR13	51694324	Inhba	3624	0.15	trans
rs2993290	CHR13	113647189	Inhba	3624	1.083E-4	trans
rs11158850	CHR14	70757171	Inhba	3624	4.354E-4	trans
RS17117326	CHR14	73017125	Inhba	3624	0.15	trans
RS17737309	CHR14	85359235	Inhba	3624	0.04	trans
rs3790050	CHR14	94421666	Inhba	3624	0.11	trans
rs11072201	CHR15	70857175	Inhba	3624	0.07	trans
rs7200513	CHR16	17219474	Inhba	3624	0.04	trans
RS3829495	CHR16	17221986	Inhba	3624	0.01	trans
rs2219403	CHR17	72059030	Inhba	3624	0.07	trans
RS12452652	CHR17	72235560	Inhba	3624	7.688e-6	trans
RS9646596	CHR18	53049211	Inhba	3624	0.02	trans
rs17594526	CHR18	53058237	Inhba	3624	0.03	trans
rs11152369	CHR18	53066327	Inhba	3624	0.16	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
去：0005179	hormone activity	塔斯		12456957
GO:0005125	细胞因子活性	艾达		9884026
去:0008083	growth factor activity	塔斯		12324653
GO:0017106	activin inhibitor activity	塔斯		12456957
GO:0042802	相同的蛋白质结合	新闻学会		2575216
GO：0048184	follistatin binding	新闻学会		16198295
生物过程	GO term	Evidence	Neuro keywords	PubMed ID
去：0007399	nervous system development	NAS	neurite (GO term level: 5)	10320815
GO:0000082	G1/S transition of mitotic cell cycle	艾达		9884026
去：0001501	骨骼系统开发	塔斯		10865214
去：0001541	ovarian follicle development	NAS		9166111
去：0007267	cell-cell signaling	塔斯		12456957
去：0006917	induction of apoptosis	艾达		8267637
去：0007166	细胞表面受体连接的信号转导	塔斯		12456957
去：0007050	细胞周期停滞	艾达		9884026
GO:0009605	对外部刺激的反应	塔斯		10320815
GO:0006952	defense response	塔斯		12456957
GO:0042326	negative regulation of phosphorylation	塔斯		12456957
去：0030154	cell differentiation	塔斯		12456957
GO:0042541	hemoglobin biosynthetic process	艾达		1310063
GO:0032925	激活素受体信号通路的调节	艾达		9884026
GO:0030308	细胞生长的负调控	艾达		9884026
GO:0040007	growth	IEA		-
GO：0045648	红细胞分化的阳性调节	艾达		9032295
GO：0045650	negative regulation of macrophage differentiation	塔斯		12456957
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	艾达		12702211
GO：0046881	positive regulation of follicle-stimulating hormone secretion	塔斯		12456957
GO：0046882	卵泡刺激激素分泌的阴性调节	NAS		3267209
GO:0045077	negative regulation of interferon-gamma biosynthetic process	塔斯		12456957
GO：0045786	negative regulation of cell cycle	艾达		9884026
GO：0045578	B细胞分化的负调控	塔斯		12456957
细胞分量	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	艾达		12213882
GO:0043509	activin A complex	艾达		7890768
GO:0043512	inhibin A complex	艾达		7890768

第四节P。rotein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACVR1	Actri \|ACVR1A \|ACVRLK2 \|ALK2 \|fop \|Skr1 \|TSRI	激活素A受体，I型	-	HPRD	11266516
ACVR1B	ACTRIB \| ACVRLK4 \| ALK4 \| SKR2	激活素A受体，I型B	Affinity Capture-Western	BioGRID	9202237
ACVR1B	ACTRIB \| ACVRLK4 \| ALK4 \| SKR2	激活素A受体，I型B	-	HPRD	8397373
ACVR2A	Actrii \|ACVR2	激活素A受体，I型IA	Affinity Capture-Western	BioGRID	9202237\|10746731
ACVR2A	Actrii \|ACVR2	激活素A受体，I型IA	-	HPRD	11266516
ACVR2B	ACTRIIB \| ActR-IIB \| MGC116908	激活素A受体，I型IB	-	HPRD，Biogrid	9202237
chrdl2	BNF1 \| CHL2 \| DKFZp586N2124 \| FKSG37	像Chordin一样2	-	HPRD，Biogrid	15094188
ENG	CD105 \|结束\|FLJ41744 \|HHT1 \|ORW \|ORW1	内聚物	-	HPRD	9872992
FSTL3	FLRG \| FSRP	follistatin样3（分泌的糖蛋白）	-	HPRD，Biogrid	11459787
IGFBP7	FSTL2 \|IGFBP-7 \|IGFBP-7V \|IGFBPRP1 \|Mac25 \|PSF	insulin-like growth factor binding protein 7	-	HPRD，Biogrid	10859029
INHA	-	抑制素，α	-	HPRD	11134153
Inhba	EDF \|frp	inhibin, beta A	-	HPRD	11134153
Inhba	EDF \|frp	inhibin, beta A	激活素A与自身相互作用以形成同型二聚体。	BIND	8015550
INHBB	MGC157939	inhibin, beta B	-	HPRD	11134153
INHBC	IHBC	inhibin, beta C	-	HPRD	11134153
TGFBR3	BGCAN \|βlycan	转化生长因子，β受体III	-	HPRD	10746731

V.途径注释

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG细胞因子细胞因子受体相互作用	267	161	All SZGR 2.0 genes in this pathway
kegg tgf beta信号通路	86	64	All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY	26	21	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	200	136	All SZGR 2.0 genes in this pathway
REACTOME糖蛋白激素	12	8	All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE HORMONE BIOSYNTHESIS	14	10	All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央	285	181	All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性	351	230	All SZGR 2.0 genes in this pathway
Sengupta鼻咽癌	294	178	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP	73	50	All SZGR 2.0 genes in this pathway
turashvili乳房小叶癌与导管正常	69	38	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE DN	66	44	All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS	579	346	All SZGR 2.0 genes in this pathway
KHSV miRNAS DN的Samols目标	62	35	All SZGR 2.0 genes in this pathway
乳腺癌腔与基础DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
vecchi胃癌先进与早期	175	120	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP	136	80	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN	41	29	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP	204	140	All SZGR 2.0 genes in this pathway
Senese HDAC2靶向	114	66	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP	141	75	All SZGR 2.0 genes in this pathway
Kim WT1靶向	214	155	All SZGR 2.0 genes in this pathway
Kim WT1目标12小时DN	209	122	All SZGR 2.0 genes in this pathway
Graham CML静止与正常分裂	57	33	All SZGR 2.0 genes in this pathway
Graham CML划分与正常静止DN	95	57	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP	66	47	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa转变为可逆DN	29	21	All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment	536	340	All SZGR 2.0 genes in this pathway
Olsson E2F3靶向DN	49	33	All SZGR 2.0 genes in this pathway
Rashi对电离辐射5的响应5	147	89	All SZGR 2.0 genes in this pathway
牛甲基化的乳腺癌	35	25	All SZGR 2.0 genes in this pathway
Li Wilms肿瘤与胎儿肾脏2 DN	51	42	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力	811	508	All SZGR 2.0 genes in this pathway
里克曼肿瘤分化了井和DN不良	382	224	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发12小时DN	57	45	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN	45	33	All SZGR 2.0 genes in this pathway
gotzmann上皮到间充质过渡	69	55	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
Amit EGF响应60 MCF10A	39	24	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 60 MCF10A	57	42	All SZGR 2.0 genes in this pathway
张对IKK抑制剂和TNF的反应	223	140	All SZGR 2.0 genes in this pathway
丁肺癌显着突变	26	22	All SZGR 2.0 genes in this pathway
Onder CDH1目标2 DN	464	276	All SZGR 2.0 genes in this pathway
CERVERA SDHB靶向1个	118	66	All SZGR 2.0 genes in this pathway
Jechlinger上皮到间充质转变	71	51	All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP	83	56	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP	207	145	All SZGR 2.0 genes in this pathway
Lenaour树突状细胞成熟	114	84	All SZGR 2.0 genes in this pathway
MLL AF9融合的Kumar目标	405	264	All SZGR 2.0 genes in this pathway
liang被甲基化2沉默2	53	34	All SZGR 2.0 genes in this pathway
牙肺纹状横纹肌肉瘤DN	408	274	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
NIELSEN LIPOSARCOMA DN	19	8	All SZGR 2.0 genes in this pathway
Browne HCMV感染48小时DN	504	323	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN	245	144	All SZGR 2.0 genes in this pathway
罗德韦尔老化的肾脏没有血液	222	139	All SZGR 2.0 genes in this pathway
罗德韦尔老化的肾脏	487	303	All SZGR 2.0 genes in this pathway
麦克拉克兰牙科龋齿	253	147	All SZGR 2.0 genes in this pathway
de yy1靶向DN	92	64	All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP	56	36	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP	260	174	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP	111	70	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
在肿瘤血管生成期间沉默的Hellebrekers	80	56	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A	67	52	All SZGR 2.0 genes in this pathway
Rutella对CSF2RB和IL4的响应	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3	128	68	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
Nakayama软组织肿瘤PCA2 UP	87	50	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN	222	147	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2	57	39	All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP	100	70	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP	199	143	All SZGR 2.0 genes in this pathway
Pedrioli mir31靶向	221	120	All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP	63	43	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway
ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE	64	40	All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP	110	68	All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP	86	54	All SZGR 2.0 genes in this pathway
Zwang 2类由EGF瞬时诱导	51	29	All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS	344	197	All SZGR 2.0 genes in this pathway
NABA女性相关	753	411	All SZGR 2.0 genes in this pathway
NABA矩阵	1028	559	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			mirna id	miRNA seq
miRNA family	UTR start	UTR end	Match method	mirna id	miRNA seq
miR-135	412	418	m8	HSA-MIR-135A	Uauggcuuuuuuuuccuauga
miR-135	412	418	m8	HSA-MIR-135B	Uauggcuuuucauuccuaugug
miR-205	172	179	1A,m8	hsa - mir - 205	uccuucauucccggagucug

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click在这里查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click在这里to see the list of brain related miRNAs.

基因页：Inhba