Gene Page:CXCL10

Summary?
GeneID 3627
Symbol CXCL10
Synonyms C7|IFI10|INP10|IP-10|SCYB10|crg-2|gIP-10|mob-1
Description C-X-C motif chemokine ligand 10
Reference MIM:147310|HGNC:HGNC:10637|Ensembl:ENSG00000169245|HPRD:00930|Vega:OTTHUMG00000160887
Gene type protein-coding
Map location 4q21
Pascal p-value 0.067
Fetal beta -0.622
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance与Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10915489 chr1 4321466 CXCL10 3627 0.09 trans
rs12036740 chr1 58432174 CXCL10 3627 0.04 trans
rs10789056 chr1 58457827 CXCL10 3627 0.18 trans
rs12041093 chr1 58462509 CXCL10 3627 0.01 trans
rs12023109 chr1 58482942 CXCL10 3627 0.01 trans
rs473019 chr1 72296394 CXCL10 3627 3.789E-4 trans
rs17359517 chr1 115381897 CXCL10 3627 0.11 trans
rs1342707 chr1 147264296 CXCL10 3627 9.186E-9 trans
rs12076447 chr1 159552549 CXCL10 3627 5.311E-5 trans
rs10752920 chr1 183783202 CXCL10 3627 0.13 trans
rs10494571 chr1 183930700 CXCL10 3627 9.805E-6 trans
rs6656512 chr1 223644438 CXCL10 3627 0.08 trans
rs4027083 chr1 234452908 CXCL10 3627 0.05 trans
rs2907143 chr1 243147434 CXCL10 3627 0.05 trans
rs10495652 chr2 17139288 CXCL10 3627 0.09 trans
rs6531271 chr2 17139932 CXCL10 3627 0.09 trans
rs12620194 chr2 17148003 CXCL10 3627 0.09 trans
rs16987384 chr2 20328893 CXCL10 3627 0.09 trans
rs17042744 chr2 21824821 CXCL10 3627 0 trans
rs918897 chr2 21825859 CXCL10 3627 0.08 trans
rs2113625 chr2 21828617 CXCL10 3627 0 trans
rs17680142 chr2 21849670 CXCL10 3627 0 trans
rs6547745 chr2 21852551 CXCL10 3627 0 trans
rs6758775 chr2 21887142 CXCL10 3627 0.02 trans
rs17042868 chr2 21895688 CXCL10 3627 0 trans
rs11893111 chr2 21910980 CXCL10 3627 0 trans
rs4488633 chr2 35142820 CXCL10 3627 0.16 trans
rs6760426 chr2 66175535 CXCL10 3627 0.15 trans
rs17546660 chr2 66218021 CXCL10 3627 0.12 trans
rs2218030 chr2 184261431 CXCL10 3627 0.07 trans
rs16824418 chr2 184275364 CXCL10 3627 0.19 trans
rs17033273 chr3 10676696 CXCL10 3627 0.01 trans
rs277655 chr3 100044586 CXCL10 3627 0.14 trans
rs16847252 chr3 163481290 CXCL10 3627 2.588E-5 trans
rs2215847 chr4 25067686 CXCL10 3627 0.12 trans
rs591585 chr4 43424979 CXCL10 3627 0.07 trans
rs6551878 chr4 65690588 CXCL10 3627 0.11 trans
rs17622486 chr4 115785097 CXCL10 3627 0.05 trans
rs298465 chr4 139260859 CXCL10 3627 0.19 trans
rs11953760 chr5 9842943 CXCL10 3627 0.09 trans
rs7380779 chr5 34436068 CXCL10 3627 0 trans
rs7380792 chr5 34436187 CXCL10 3627 0 trans
rs10074060 chr5 34437321 CXCL10 3627 0.05 trans
rs7442700 chr5 34493693 CXCL10 3627 0.06 trans
rs4516856 chr5 43889206 CXCL10 3627 0.05 trans
rs31304 chr5 52942082 CXCL10 3627 0.01 trans
rs10514893 chr5 59657694 CXCL10 3627 0.11 trans
rs10514894 chr5 59658797 CXCL10 3627 0.18 trans
rs10515260 chr5 97076547 CXCL10 3627 2.687E-12 trans
rs10515267 chr5 100128201 CXCL10 3627 0.03 trans
rs17780121 chr5 100168511 CXCL10 3627 0.05 trans
rs17780992 chr5 100195770 CXCL10 3627 0.05 trans
rs9313842 chr5 159690030 CXCL10 3627 0.05 trans
rs6920921 chr6 8884160 CXCL10 3627 0.11 trans
rs2327748 chr6 14082533 CXCL10 3627 0.01 trans
rs12195984 0 CXCL10 3627 0.14 trans
rs10498827 chr6 65470694 CXCL10 3627 0.08 trans
rs16869716 chr6 71743471 CXCL10 3627 9.782E-8 trans
rs2093506 chr6 154232014 CXCL10 3627 0.06 trans
rs6455821 chr6 162825101 CXCL10 3627 0.06 trans
rs6956395 chr7 28072244 CXCL10 3627 0.01 trans
rs6462122 chr7 29137630 CXCL10 3627 0.01 trans
rs7776597 chr7 51015581 CXCL10 3627 0.08 trans
rs3937454 chr7 152676939 CXCL10 3627 0.19 trans
rs7790094 chr7 152786528 CXCL10 3627 0.02 trans
rs4410820 chr7 152853659 CXCL10 3627 0.05 trans
rs17075051 chr8 5761144 CXCL10 3627 0.02 trans
rs17075079 chr8 5765448 CXCL10 3627 0.05 trans
rs10503341 chr8 5775097 CXCL10 3627 0.18 trans
rs9325708 chr8 12402940 CXCL10 3627 7.414E-4 trans
rs7817084 chr8 43242956 CXCL10 3627 0.14 trans
rs10959381 chr9 10936134 CXCL10 3627 0.11 trans
rs12344698 chr9 16750142 CXCL10 3627 0.07 trans
rs17376956 chr10 11179948 CXCL10 3627 0.17 trans
rs3802522 chr10 28341865 CXCL10 3627 4.127E-7 trans
rs10508730 chr10 28403391 CXCL10 3627 4.127E-7 trans
rs16936983 chr10 37871050 CXCL10 3627 0.14 trans
rs1344342 chr10 37958911 CXCL10 3627 0.14 trans
rs1108733 chr10 37993286 CXCL10 3627 0.14 trans
rs4917410 chr10 95872539 CXCL10 3627 0.17 trans
rs7089703 chr10 119182182 CXCL10 3627 0.06 trans
rs11246002 chr11 211446 CXCL10 3627 0.16 trans
rs10743139 chr11 10425326 CXCL10 3627 0.02 trans
rs2508654 chr11 120405519 CXCL10 3627 0.02 trans
rs1944608 chr11 123091803 CXCL10 3627 0.09 trans
rs17127157 chr11 123092323 CXCL10 3627 0.09 trans
rs10893162 chr11 124076268 CXCL10 3627 0.09 trans
rs11219545 chr11 124136438 CXCL10 3627 0.09 trans
rs11219646 chr11 124279239 CXCL10 3627 0.04 trans
rs7102988 chr11 130134440 CXCL10 3627 0.16 trans
rs7972594 chr12 11724913 CXCL10 3627 0.06 trans
rs10491979 chr12 11727969 CXCL10 3627 0.06 trans
rs11171083 chr12 55192688 CXCL10 3627 0.08 trans
rs1542363 chr12 55213677 CXCL10 3627 0.08 trans
rs1542364 chr12 55213700 CXCL10 3627 0.08 trans
rs7298952 chr12 55216414 CXCL10 3627 0.08 trans
rs921723 chr12 55221358 CXCL10 3627 0.08 trans
rs2219716 chr12 86139883 CXCL10 3627 0.04 trans
rs11107750 chr12 95241256 CXCL10 3627 0.11 trans
rs7304048 chr12 95292947 CXCL10 3627 0.11 trans
rs4762419 chr12 95771835 CXCL10 3627 0.09 trans
rs3751152 chr12 121442063 CXCL10 3627 0.01 trans
rs9645995 chr13 47246048 CXCL10 3627 0.01 trans
rs9598109 chr13 60878618 CXCL10 3627 0.13 trans
rs17081091 chr13 66867486 CXCL10 3627 0.13 trans
rs4328300 chr13 104315373 CXCL10 3627 0.12 trans
rs9519133 chr13 104325831 CXCL10 3627 0.12 trans
rs6491786 chr13 104328014 CXCL10 3627 0.12 trans
rs9519135 chr13 104332307 CXCL10 3627 0.12 trans
rs9519136 chr13 104332406 CXCL10 3627 0.12 trans
rs17111522 chr14 41634403 CXCL10 3627 0.18 trans
rs9989174 chr14 82663493 CXCL10 3627 0.02 trans
rs1958669 chr14 82675761 CXCL10 3627 0.04 trans
rs2219618 chr15 54109136 CXCL10 3627 0.11 trans
rs6494052 chr15 59295924 CXCL10 3627 0.11 trans
rs6497089 chr15 94163348 CXCL10 3627 3.036E-4 trans
rs7170017 chr15 94179359 CXCL10 3627 0.06 trans
rs6498459 chr16 13795898 CXCL10 3627 0.07 trans
rs963303 chr16 73372497 CXCL10 3627 0.01 trans
rs4303487 chr16 90033254 CXCL10 3627 2.809E-7 trans
rs6587203 chr17 19671457 CXCL10 3627 0.03 trans
rs205113 chr17 19673879 CXCL10 3627 0.03 trans
rs205111 chr17 19675103 CXCL10 3627 0.03 trans
rs205110 chr17 19675587 CXCL10 3627 0.03 trans
rs205093 chr17 19685712 CXCL10 3627 0.03 trans
rs157406 chr17 19710650 CXCL10 3627 0.03 trans
rs157402 chr17 19720588 CXCL10 3627 0.03 trans
rs157396 chr17 19726832 CXCL10 3627 0.03 trans
rs157397 chr17 19729494 CXCL10 3627 0.03 trans
rs8074258 0 CXCL10 3627 0.03 trans
rs172186 chr17 19780658 CXCL10 3627 0.01 trans
rs281334 chr17 19782079 CXCL10 3627 0.03 trans
rs4586510 chr17 19783973 CXCL10 3627 0.03 trans
rs2448755 chr18 65344801 CXCL10 3627 0.12 trans
rs16966813 chr19 32698878 CXCL10 3627 4.503E-4 trans
rs6076060 chr20 23345068 CXCL10 3627 0.12 trans
rs965018 chr20 41531585 CXCL10 3627 0.18 trans
rs9619990 chr22 42163258 CXCL10 3627 0.13 trans
rs17342476 chrX 102243644 CXCL10 3627 4.175E-5 trans
rs17342483 chrX 102250155 CXCL10 3627 9.008E-4 trans
rs17342504 chrX 102272107 CXCL10 3627 4.175E-5 trans
snp_a-2138851 0 CXCL10 3627 4.175E-5 trans
snp_a-2059928 0 CXCL10 3627 4.175E-5 trans
rs5957194 chrX 118769609 CXCL10 3627 4.136E-5 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RFC1 0.83 0.83
CLPX 0.83 0.84
METT10D 0.83 0.83
HOOK3 0.82 0.85
ZNF397 0.82 0.85
ZNF426 0.82 0.85
TPR 0.82 0.81
XIAP 0.81 0.84
PCM1 0.81 0.82
NEK4 0.81 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.65 -0.66
AF347015.21 -0.63 -0.67
MT-CO2 -0.61 -0.63
AF347015.27 -0.60 -0.62
HIGD1B -0.60 -0.62
IFI27 -0.60 -0.62
MT-CYB -0.58 -0.60
AF347015.8 -0.58 -0.60
AF347015.15 -0.55 -0.58
AF347015.33 -0.54 -0.56

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 71 51 All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 56 44 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 34 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 57 27 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205 140 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194 122 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204 140 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 57 33 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 66 47 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
KOINUMA COLON CANCER MSI UP 16 11 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170 114 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207 128 All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 UP 20 11 All SZGR 2.0 genes in this pathway
EBAUER MYOGENIC TARGETS OF PAX3 FOXO1 FUSION 50 26 All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 73 47 All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 50 27 All SZGR 2.0 genes in this pathway
YAN ESCAPE FROM ANOIKIS 24 19 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 120 MCF10A 65 44 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 All SZGR 2.0 genes in this pathway
LEI HOXC8 TARGETS DN 17 13 All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 52 40 All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 101 66 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 78 50 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 83 56 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP 62 35 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 68 44 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 35 21 All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 77 57 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 47 39 All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 92 68 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
MOSERLE IFNA RESPONSE 31 19 All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 73 55 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN DN 18 16 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 77 56 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP 91 63 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181 106 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 109 68 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K27ME3 54 32 All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 44 30 All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 30 19 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 76 46 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP2 60 38 All SZGR 2.0 genes in this pathway
KIM GLIS2 TARGETS UP 84 61 All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP 100 70 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 114 62 All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 128 81 All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 86 54 All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 95 54 All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway