Gene Page:INPP5A

概括?
基因 3632
象征 INPP5A
Synonyms 5PTASE
德scription inositol polyphosphate-5-phosphatase A
Reference MIM：600106|HGNC:HGNC:6076|运用:ENSG00000068383|HPRD:02521|织女:OTTHUMG00000019293
Gene type protein-coding
Map location 10q26.3
Pascal p-value 0.225
Sherlock p-value 0.456
Fetal beta -1.099
DMG 1 (# studies)
eGene Myers' cis & trans
Support COMPOSITESET

数据源中的基因
Gene set name Method of gene set 德scription Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
DNM:Xu_2012 Whole Exome Sequencing analysis 德novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.03487

第一节遗传学和表观遗传学注释

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 筛 CG46 Trait Study
INPP5A chr10 134463942 C T NM_005539 p.80A>V 错过 精神分裂症 DNM:Xu_2012

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
CG13795838 10 134539818 INPP5A 3.066e-4 0.272 0.04 DMG:Wockner_2014
cg22918356 10 134496823 INPP5A 3.212E-4 0.35 0.04 DMG:Wockner_2014
cg05030346 10 134596943 INPP5A 4.631E-4 -0.795 0.046 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2814453 chr10 134408415 INPP5A 3632 0.14 cis
rs7094522 chr10 134482925 INPP5A 3632 0.1 cis
rs1538616 chr14 51455471 INPP5A 3632 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004437 inositol or phosphatidylinositol phosphatase activity IEA -
GO:0004445 inositol-polyphosphate 5-phosphatase activity NAS 8006039
GO:0016787 hydrolase activity IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007154 cell communication NAS -
GO:0008150 biological_process nd -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component nd -
去：0016020 membrane NAS 8006039

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG肌醇磷酸代谢 54 42 该途径中的所有SZGR 2.0基因
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 76 56 该途径中的所有SZGR 2.0基因
THUM SYSTOLIC HEART FAILURE UP 423 283 该途径中的所有SZGR 2.0基因
OSMAN BLADDER CANCER UP 404 246 该途径中的所有SZGR 2.0基因
SENESE HDAC3 TARGETS UP 501 327 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 该途径中的所有SZGR 2.0基因
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 该途径中的所有SZGR 2.0基因
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 该途径中的所有SZGR 2.0基因
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 98 59 该途径中的所有SZGR 2.0基因
DER IFN GAMMA RESPONSE DN 11 9 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
YAGI AML SURVIVAL 129 87 该途径中的所有SZGR 2.0基因
Kayo衰老的肌肉 244 165 该途径中的所有SZGR 2.0基因
由组蛋白乙酰化调节的玛丽亚达森 83 49 该途径中的所有SZGR 2.0基因
MARIADASON RESPONSE TO CURCUMIN SULINDAC 5 23 17 该途径中的所有SZGR 2.0基因
DOUGLAS BMI1 TARGETS UP 566 371 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性3 720 440 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性5 482 296 该途径中的所有SZGR 2.0基因
KYNG DNA DAMAGE BY UV 62 43 该途径中的所有SZGR 2.0基因
KYNG DNA DAMAGE UP 226 164 该途径中的所有SZGR 2.0基因
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 该途径中的所有SZGR 2.0基因
SWEET LUNG CANCER KRAS DN 435 289 该途径中的所有SZGR 2.0基因
BOYAULT LIVER CANCER SUBCLASS G1 UP 113 70 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 181 101 该途径中的所有SZGR 2.0基因
NIELSEN GIST 98 66 该途径中的所有SZGR 2.0基因
Smad2或Smad3的Koinuma目标 824 528 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 175 181 1A hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain agagguaguagguugcauagu
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
mir-137 1423 1430 1A,m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-142-3p 1194 1201 1A,m8 hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA
mir-150 955 961 1A hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
mir-151 690 696 m8 hsa-miR-151brain ACUAGACUGAAGCUCCUUGAGG
miR-181 838 844 m8 hsa-miR-181abrain aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-23 840 847 1A,m8 hsa-miR-23abrain aucacauugccagggauucc
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-323 840 846 1A hsa-miR-323brain gcacauuacggucgaccucu
miR-410 563 569 1A hsa-miR-410 aauauaacacagauggcugu
miR-485-5p 143 149 m8 HSA-MIR-485-5p AGAGGCUGGCCGUGAUGAAUUC
HSA-MIR-485-5p AGAGGCUGGCCGUGAUGAAUUC
mir-491 128 134 1A hsa-miR-491brain AGUGGGGAACCCUUCCAUGAGGA
mir-495 904 910 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
mir-96 921 927 m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC