Gene Page:IREB2

年代ummary?
GeneID 3658
年代ymbol IREB2
年代ynonyms ACO3|IRP2|IRP2AD
Description iron responsive element binding protein 2
Reference MIM:147582|HGNC:HGNC:6115|Ensembl:ENSG00000136381|HPRD:08858|Vega:OTTHUMG00000143861
Gene type protein-coding
Map location 15q25.1
Pascal p-value 1.749E-7
Fetal beta 1.419
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 1

年代ection I. Genetics and epigenetics annotation

@CV:PheWAS

年代NP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs13180 15 78789488 null 1.499 IREB2 null

@eQTL annotation

年代NP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7370564 0 IREB2 3658 0.05 trans

年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
DOCK2 0.69 0.59
ITGB2 0.69 0.62
CD4 0.66 0.64
DEF6 0.65 0.59
WDFY4 0.64 0.60
PTPN6 0.63 0.57
APBB1IP 0.63 0.56
CSF1R 0.63 0.60
CSF3R 0.63 0.54
BIN2 0.62 0.61
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
C8orf59 -0.31 -0.34
AC087071.1 -0.30 -0.33
NDUFAF2 -0.29 -0.36
RPL31 -0.28 -0.38
PFDN5 -0.27 -0.35
PFDN4 -0.27 -0.35
年代T20 -0.27 -0.34
COMMD3 -0.26 -0.28
ZNF32 -0.26 -0.32
RPS7 -0.26 -0.34

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID MYC ACTIV PATHWAY 79 62 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN 123 78 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
年代ENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 103 58 All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN 73 45 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172 107 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 12 36 18 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 97 72 All SZGR 2.0 genes in this pathway
年代TEARMAN LUNG CANCER EARLY VS LATE UP 125 89 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS DN 32 27 All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289 187 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有SATB1的目标 344 215 All SZGR 2.0 genes in this pathway