SZGR2 - Beplay体育中心

Summary？

基因	3667
Symbol	IRS1
Synonyms	HIRS-1
Description	insulin receptor substrate 1
参考erence	MIM：147545\|HGNC:HGNC:6125\|Ensembl:ENSG00000169047\|HPRD:00943\|Vega:OTTHUMG00000133179
Gene type	蛋白质编码
Map location	2Q36
Pascal p-value	0.008
胎儿β	1.215
DMG	3 (# studies)
主持人	Myers' cis & trans
Support	G2CDB.HUMANNRC G2CDB.HUMANPSP CompositeSet Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	全基因组DNA甲基化分析	this dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	4
DMG：Montano_2016	全基因组DNA甲基化分析	this dataset includes 172 replicated associations between CpGs with schizophrenia.	4
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	4
DNM:Xu_2012	Whole Exome Sequencing analysis	De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study
PMID：cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA	Genome scan meta-analysis (All samples)	PSR：0.00916
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01016
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0631

Section I. Genetics and epigenetics annotation

DNMtable

Gene	Chromosome	Position	参考	alt	transcript	AA change	Mutation type	筛	CG46	trait	学习
IRS1	chr2	227661300	C	t	NM_005544	p.719e> k	missense			Schizophrenia	DNM:Xu_2012

Differentially methylated gene

Probe	Chromosome	Position	最近的基因	p（dis）	Beta (dis)	fdr（dis）	学习
cg14078053	2	227661656	IRS1	2.15e-4	0.006	0.16	DMG：Montano_2016
cg04751089	2	227659636	IRS1	1.095E-4	0.469	0.028	DMG：Wockner_2014
cg05263838	2	227659406	IRS1	1.541E-4	0.778	0.032	DMG：Wockner_2014
cg03298167	2	227663911	IRS1	5.11E-8	-0.027	1.35 e-5	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS17088272	CHR18	71410110	IRS1	3667		0.19		trans
RS17088278	CHR18	71412692	IRS1	3667		0.13		trans

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
the bar shown representes the lower 25% and upper 25% of the expression distribution.

top co-expressed genes in brain regions

前10个积极共表达的基因
Gene	Pearson's Correlation	Spearman's Correlation
ruvbl2	0.94	0.95
C17orf49	0.93	0.94
PSMB7	0.93	0.94
PRMT1	0.93	0.95
PSMA7	0.93	0.94
trim39	0.93	0.92
CLPP	0.93	0.92
ERGIC3	0.93	0.95
RRP9	0.93	0.93
DDX49	0.93	0.93

top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.27	-0.72	-0.82
AF347015.33	-0.72	-0.82
AF347015.8	-0.71	-0.81
MT-CO2	-0.70	-0.78
mt-cyb	-0.70	-0.81
AF347015.15	-0.70	-0.82
AF347015.26	-0.69	-0.84
AF347015.31	-0.69	-0.77
AF347015.2	-0.69	-0.81
AF347015.9	-0.65	-0.78

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0004871	signal transducer activity	tAS		1311924\|8513971
去：0005159	胰岛素样生长因子受体结合	IPI		7541045
去：0005158	insulin receptor binding	IPI		7537849\|7559478
去：0005069	transmembrane receptor protein tyrosine kinase docking protein activity	tAS		1648180
去：0005515	蛋白质结合	IPI		8388384\|9295312\|11018022
GO:0042169	SH2域结合	ISS		-
GO：0019901	protein kinase binding	IEA		-
GO:0043548	磷酸肌醇3-激酶结合	IPI		16043515
GO:0043548	磷酸肌醇3-激酶结合	ISS		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0007165	信号转导	tAS		1311924
GO:0008286	胰岛素受体信号通路	IPI		7537849\|7559478
GO：0048009	胰岛素样生长因子受体信号通路	IPI		7541045
GO:0043491	protein kinase B signaling cascade	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005792	microsome	ISS		-
GO:0005634	nucleus	ISS		-
去：0005737	cytoplasm	ISS		-
GO:0005901	小屋	IDA		15182363
GO:0005886	plasma membrane	EXP		12167717

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	实验	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	V-Akt鼠胸腺瘤病毒癌基因同源1	-	HPRD,BioGRID	10497255
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	-	HPRD	9174053
AP3S1	CLAPS3 \| Sigma3A	adaptor-related protein complex 3, sigma 1 subunit	-	HPRD,BioGRID	9792713
ATP2A1	ATP2A \| SERCA1	ATPase，CA ++运输，心肌，快速抽搐1	-	HPRD	9295312
BCL2	Bcl-2	B-cell CLL/lymphoma 2	亲和力捕获 - 韦斯特恩	Biogrid	10679027
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	-	HPRD,BioGRID	10679027
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	-	HPRD	11035789
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	保守的螺旋环螺旋无处不在激酶	-	HPRD,BioGRID	12351658
FRAP1	FLJ44809 \|frap \|frap2 \|mtor \|RAFT1 \|Rapt1	FK506 binding protein 12-rapamycin associated protein 1	亲和力捕获 - 韦斯特恩	Biogrid	11287630
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	重构的复合物	Biogrid	8621530
GRB2	灰烬\|EGFRBP-GRB2 \|Grb3-3 \|MST084 \|MSTP084	growth factor receptor-bound protein 2	-	HPRD	7488107
GRB2	灰烬\|EGFRBP-GRB2 \|Grb3-3 \|MST084 \|MSTP084	growth factor receptor-bound protein 2	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	8491186\|8536716 \|12173038
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	IGFIR interacts with IRS-1.	BIND	7541045
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	IRS-1与IGF-IR相互作用。这种相互作用是根据大鼠IRS-1和人IGF-IR之间的相互作用建模的。	BIND	10026153
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD,BioGRID	7559507
ikbkb	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	亲和力捕获 - 韦斯特恩	Biogrid	12351658
ikbkg	AMCBX1 \|FIP-3 \|fip3 \|fip3p \|ikk-gamma \|IP \|IP1 \|IP2 \|IPD2 \|Nemo	B细胞，激酶γ中Kappa光多肽基因增强子的抑制剂	-	HPRD	12351658
IL4R	CD124 \| IL4RA	interleukin 4 receptor	-	HPRD,BioGRID	8599766
INSR	CD220 \|HHF5	insulin receptor	IRS-1 interacts with IR. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human IR.	BIND	10026153
INSR	CD220 \|HHF5	insulin receptor	Insulin Receptor Substrate-1 Binds to the Insulin Receptor. This interaction is modeled on demonstrated interaction between human IR and rat IRS-1	BIND	8626379
INSR	CD220 \|HHF5	insulin receptor	-	HPRD,BioGRID	11606564
JAK1	jak1a \|jak1b \|JTK3	Janus激酶1（蛋白酪氨酸激酶）	亲和力捕获 - 韦斯特恩生化活动	Biogrid	7499365\|9492017
JAK2	JTK10	Janus激酶2（蛋白酪氨酸激酶）	亲和力捕获 - 韦斯特恩生化活动	Biogrid	9492017\|11208867
JAK3	JAK-3 \| JAK3_HUMAN \| JAKL \| L-JAK \| LJAK	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	-	HPRD,BioGRID	7499365
KHDRBS1	FLJ34027 \|SAM68 \|p62	KH domain containing, RNA binding, signal transduction associated 1	亲和力捕获 - 韦斯特恩	Biogrid	11604231
MAPK8	jnk \|JNK1 \|JNK1A2 \|JNK21B1/2 \|prkm8 \|SAPK1	有丝分裂原激活的蛋白激酶8	-	HPRD,BioGRID	10722755\|11606564 \|12417588
MAPK9	JNK-55 \|jnk2 \|jnk2a \|jnk2alpha \|JNK2B \|jnk2beta \|prkm9 \|SAPK \|p54a \|P54ASAPK	有丝分裂原激活的蛋白激酶9	-	HPRD	12417588
NISCH	FLJ14425 \|FLJ40413 \|FLJ90519 \|I-1 \|iras \|KIAA0975	Nischarin	亲和力捕获 - 韦斯特恩	Biogrid	11912194
PHIP	FLJ20705 \|FLJ45918 \|MGC90216 \|WDR11 \|NDRP	pleckstrin同源域相互作用蛋白	-	HPRD	11018022
PIK3CA	MGC142161 \| MGC142163 \| PI3K \| p110-alpha	phosphoinositide-3-kinase、催化αpolypeptide	亲和力捕获 - 韦斯特恩	Biogrid	16354680
PIK3R1	GRB1 \| p85 \| p85-ALPHA	磷酸肌醇3-激酶，调节亚基1（alpha）	亲和力捕获 - 韦斯特恩 Far Western	Biogrid	1381348\|12107746 \|12173038\|12730242
PIK3R1	GRB1 \| p85 \| p85-ALPHA	磷酸肌醇3-激酶，调节亚基1（alpha）	-	HPRD	1381348\|12173038
PIK3R1	GRB1 \| p85 \| p85-ALPHA	磷酸肌醇3-激酶，调节亚基1（alpha）	-	HPRD	12220227
PIK3R2	P85B \|P85 \|p85-beta	磷酸肌醇3-激酶，调节亚基2（beta）	IRS-1与p85-beta相互作用。这种相互作用是基于未知物种的未指定物种和p85-beta的IRS-1之间的相互作用进行建模的。	BIND	11172806
PIK3R2	P85B \|P85 \|p85-beta	磷酸肌醇3-激酶，调节亚基2（beta）	-	HPRD	11120660
PIK3R3	DKFZp686P05226 \| FLJ41892 \| p55 \| p55-GAMMA	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	-	HPRD,BioGRID	7542745\|9415396 \|10417350
PRKCD	May1 \|MGC49908 \|PKCD \|npkc-delta	蛋白激酶C，三角洲	-	HPRD,BioGRID	12031982
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2protein tyrosine kinase 2	-	HPRD,BioGRID	9822703
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	-	HPRD,BioGRID	10660596
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	8505282\|9756938
ptprc	B220 \|CD45 \|CD45R \|GP180 \|LCA \|ly5 \|T200	蛋白酪氨酸磷酸酶，受体类型，C	-	HPRD,BioGRID	8557683
PTPRF	FLJ43335 \| FLJ45062 \| FLJ45567 \| LAR	蛋白酪氨酸磷酸酶，受体类型，F	-	HPRD	10660596
SFN	YWHAS	Stratifin	Affinity Capture-MS	Biogrid	15778465
SHC1	FLJ26504 \| SHC \| SHCA	SHC（SRC同源性2结构域）转化蛋白1	Direct interaction between IRS-1 and SHC. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human SHC	BIND	9202037
SHC1	FLJ26504 \| SHC \| SHCA	SHC（SRC同源性2结构域）转化蛋白1	-	HPRD,BioGRID	7499194
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	-	HPRD,BioGRID	11208867\|12228220
SOCS3	ATOD4 \| CIS3 \| Cish3 \| MGC71791 \| SOCS-3 \| SSI-3 \| SSI3	suppressor of cytokine signaling 3	-	HPRD	12228220
tUB	RD5	tubby homolog (mouse)	-	HPRD	10455176
tYK2	JTK1	酪氨酸激酶2	-	HPRD,BioGRID	8550573
UBTF	NOR-90 \| UBF	上游绑定记录ion factor, RNA polymerase I	-	HPRD,BioGRID	12554758
YWHAB	GW128 \|HS1 \|KCIP-1	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，β多肽	-	HPRD,BioGRID	9422753
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	IRS-1与14-3-3- epsilon同工型相互作用。这种相互作用是在人IRS-1和小鼠14-3-3- epsilon同工型之间的相互作用上建模的。	BIND	9111084
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	-	HPRD,BioGRID	9111084\|9312143
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	亲和力捕获 - 韦斯特恩	Biogrid	11969417
YWHAZ	KCIP-1\|MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD,BioGRID	9312143

Section V. Pathway annotation

Pathway name	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY	67	57	All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS	47	41	All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION	42	29	All SZGR 2.0 genes in this pathway
Biocarta GH途径	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1 PATHWAY	21	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL4 PATHWAY	11	8	All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY	38	26	All SZGR 2.0 genes in this pathway
BIOCARTA INSULIN PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES	27	23	All SZGR 2.0 genes in this pathway
心肌细胞中的SIG胰岛素受体途径	51	41	All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY	65	43	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID RET路径	39	29	All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY	58	46	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	19	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出	137	105	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL ATTENUATION	14	8	All SZGR 2.0 genes in this pathway
REACTOME SOS MEDIATED SIGNALLING	14	13	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
Reactome PI3K级联	71	51	All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN	62	35	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN	241	146	All SZGR 2.0 genes in this pathway
Senese HDAC1靶向DN	260	143	All SZGR 2.0 genes in this pathway
Kim WT1靶向DN	459	276	All SZGR 2.0 genes in this pathway
甲状腺癌的Rodrigues分化不佳的DN	805	505	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN	485	334	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP	211	136	All SZGR 2.0 genes in this pathway
BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER	22	19	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK TARGETS	18	15	All SZGR 2.0 genes in this pathway
农民乳腺癌基础与仙女	330	215	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌	358	245	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP	53	37	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN	68	44	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN	50	32	All SZGR 2.0 genes in this pathway
Browne HCMV感染10小时DN	56	37	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING SCAR UP	30	21	All SZGR 2.0 genes in this pathway
Browne HCMV感染18小时DN	178	121	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
Bandres对Carmustin没有MGMT 48小时DN的响应	32	25	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN	161	105	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8	40	29	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP	280	183	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
Massarweh对雌二醇的反应	61	47	All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化	940	425	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀	510	309	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP	260	174	All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应	342	220	All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP	46	28	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP	167	99	All SZGR 2.0 genes in this pathway
DING LUNG CANCER BY MUTATION RATE	20	18	All SZGR 2.0 genes in this pathway
清肝癌子类CTNNB1 UP	176	110	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
Johnstone Parvb目标2 DN	336	211	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN	229	135	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
Winzen通过KHSRP退化	100	70	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
ikeda mir30目标	116	87	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
通过p38部分的phong TNF响应	160	106	All SZGR 2.0 genes in this pathway
BMP7的Zhang脂肪形成	14	12	All SZGR 2.0 genes in this pathway
前列腺癌模型DN中的Acevedo FGFR1靶标	308	187	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	target position			miRNA ID	mirna seq
miRNA family	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-126/126-3p	131	137	1A	HSA-MIR-126^brain	UCGUACCGUGAGUAAUAAUGC
miR-128	232	239	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	232	239	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-145	4	10	m8	HSA-MIR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-183	671	678	1A,m8	HSA-MIR-183	UAUGGCACUGGUAGAAUUCACUG
miR-200bc/429	449	455	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-27	233	239	m8	hsa-miR-27a^brain	uucacaguggcuaaguuccgc
miR-27	233	239	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	154	160	m8	HSA-MIR-30A-5P	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	uguaaacauccccgacuggaag
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
mir-487b	132	138	m8	HSA-MIR-487B	aaucguacagggucauccacuu
mir-96	209	215	m8	HSA-MIR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhere查看与大脑相关的miRNA列表。

Gene Page:IRS1