Gene Page:ITGA2

Summary?
GeneID 3673
Symbol ITGA2
Synonyms BR|CD49B|GPIa|HPA-5|VLA-2|VLAA2
Description integrin subunit alpha 2
Reference MIM:192974|HGNC:HGNC:6137|Ensembl:ENSG00000164171|HPRD:01893|Vega:OTTHUMG00000131165
Gene type protein-coding
Map location 5 q11.2
Pascal p-value 0.056
Fetal beta 0.37
DMG 2 (# studies)
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05036937 5 52283760 ITGA2 2.5E-5 -0.006 0.068 DMG:Montano_2016
cg15676241 5 52285231 ITGA2 6.5E-9 -0.014 3.37E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某菲tal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
COL6A3 0.89 0.80
COL3A1 0.85 0.43
IGF2 0.85 0.79
C7 0.84 0.84
COL1A1 0.83 0.65
COL15A1 0.82 0.39
ALX4 0.79 0.35
OSR1 0.78 0.54
COL1A2 0.78 0.52
LUM 0.78 0.64
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHMP4A -0.25 -0.38
S100A1 -0.25 0.10
ACP6 -0.25 -0.09
GLIPR1L2 -0.25 -0.14
MRPL41 -0.25 -0.00
PIR -0.24 0.04
MSRB2 -0.24 -0.01
AC007216.4 -0.24 -0.26
HEPN1 -0.23 0.15
NDRG2 -0.23 0.13

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG ECM RECEPTOR INTERACTION 84 53 All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE 88 60 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 84 67 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 76 59 All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 92 68 All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
PID INTEGRIN1 PATHWAY 66 44 All SZGR 2.0 genes in this pathway
PID INTEGRIN CS PATHWAY 26 16 All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 49 34 All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 102 78 All SZGR 2.0 genes in this pathway
PID SYNDECAN 2 PATHWAY 33 27 All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY 25 16 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN 12 8 All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 79 48 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS 86 62 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN 91 53 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA UP 74 45 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457 269 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 AND DCC TARGETS 35 25 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN 51 42 All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE IMMORTALIZED DN 31 26 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164 118 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 MCF10A 43 26 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 240 MCF10A 57 36 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 102 67 All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 86 67 All SZGR 2.0 genes in this pathway
IYENGAR RESPONSE TO ADIPOCYTE FACTORS 10 8 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 111 68 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
《图片报》极品致癌签名 261 166 All SZGR 2.0 genes in this pathway
GHO ATF5 TARGETS DN 16 10 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
KYNG NORMAL AGING UP 19 11 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM UP 20 10 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 2HR DN 49 33 All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 84 48 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS UP 139 93 All SZGR 2.0 genes in this pathway
SUBTIL PROGESTIN TARGETS 36 25 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 136 76 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
ZHU SKIL TARGETS UP 20 14 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 1 46 33 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway