SZGR2 - Beplay体育中心

Summary？

基因	3678
象征	itga5
Synonyms	CD49e\|FNRA\|VLA-5\|VLA5A
Description	整合素亚基Alpha 5
Reference	MIM：135620\|HGNC：HGNC：6141\|Ensembl:ENSG00000161638\|HPRD:00627\|Vega：Otthumg00000169841
基因类型	蛋白质编码
Map location	12q13.13
Pascal p-value	0.451
胎儿β	-0.035
DMG	1(# studies)
主持人	Myers' cis & trans 元
Support	Ascano FMRP targets

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
DMG:vanEijk_2014	全基因组DNA甲基化分析	这个数据集包括甲醇432不同d CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	1
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关的关键字的命中：1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0066

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG09303642	12	54690818	itga5	5.18E-5	-4.226		DMG:vanEijk_2014

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS10994209	chr10	61877705	itga5	3678		0.12		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RAB8A	0.92	0.92
加纳布	0.91	0.91
HEATR6	0.91	0.94
NAT10	0.91	0.94
DET1	0.91	0.92
GEMIN5	0.91	0.94
TH1L	0.91	0.94
RPN2	0.91	0.90
rnpep	0.91	0.93
DDB1	0.91	0.92

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.77	-0.87
AF347015.31	-0.77	-0.86
AF347015.27	-0.74	-0.84
FXYD1	-0.73	-0.83
IFI27	-0.73	-0.84
AF347015.33	-0.73	-0.82
AF347015.8	-0.72	-0.84
AF347015.21	-0.72	-0.88
mt-cyb	-0.72	-0.82
CXCL14	-0.70	-0.81

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0005178	整联蛋白结合	IEA		-
去：0005509	calcium ion binding	IEA		-
去：0005515	蛋白质结合	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0007155	cell adhesion	TAS		2454952
GO:0007157	异质细胞粘附	IEA		-
GO:0007229	integrin-mediated signaling pathway	IEA		-
去：0007613	memory	IEA		-
GO:0007044	cell-substrate junction assembly	IEA		-
GO:0007159	白细胞粘附	IEA		-
GO:0033631	整合素介导的细胞细胞粘附	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
GO：0019717	突触体	IEA	突触，大脑（GO期限：7）	-
GO:0001726	ruffle	TAS		11919189
去：0005794	高尔基体	IDA		18029348
去：0005634	nucleus	IDA		18029348
去：0005737	cytoplasm	IDA		18029348
去：0016020	membrane	IEA		-
GO：0016021	膜不可或缺	IEA		-
GO:0009897	external side of plasma membrane	IEA		-
去：0008305	整联蛋白复合物	TAS		2454952

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
Angptl3	Angpt5	angiopoietin-like 3	-	HPRD	11877390
arhgap5	GFI2 \| RhoGAP5 \| p190-B	Rho GTPase激活蛋白5	-	HPRD	8537347
AUP1	-	古代无处不在蛋白1	-	HPRD,BioGRID	12042322
CD9	5H9 \| BA2 \| BTCC-1 \| DRAP-27 \| GIG2 \| MIC3 \| MRP-1 \| P24 \| TSPAN29	CD9分子	-	HPRD,BioGRID	10065872
COL18A1	FLJ27325 \|FLJ34914 \|kno \|kno1 \|MGC74745	collagen, type XVIII, alpha 1	-	HPRD	11158588
Col1a1	OI4	collagen, type I, alpha 1	-	HPRD	1693626
egfr	ERBB \|ERBB1 \|her1 \|PIG61 \|梅纳	表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类）	-	HPRD	10888683
F2	pt	coagulation factor II (thrombin)	-	HPRD	9864377
FN1	CIG \| DKFZp686F10164 \| DKFZp686H0342 \| DKFZp686I1370 \| DKFZp686O13149 \| ED-B \| FINC \| FN \| FNZ \| GFND \| GFND2 \| LETS \| MSF	纤连蛋白1	重构的复合物	Biogrid	1532572
FN1	CIG \| DKFZp686F10164 \| DKFZp686H0342 \| DKFZp686I1370 \| DKFZp686O13149 \| ED-B \| FINC \| FN \| FNZ \| GFND \| GFND2 \| LETS \| MSF	纤连蛋白1	-	HPRD	9211865\|11801679
GIPC1	C19orf3 \| GIPC \| GLUT1CBP \| Hs.6454 \| IIP-1 \| MGC15889 \| MGC3774 \| NIP \| RGS19IP1 \| SEMCAP \| SYNECTIIN \| SYNECTIN \| TIP-2	GIPC PDZ domain containing family, member 1	-	HPRD,BioGRID	11479315
ILK	DKFZP686F1765 \|P59	整联蛋白连接激酶	亲和力捕获 - 韦斯特恩	Biogrid	8538749
ITGB1	CD29 \|fnrb \|GPIIA \|MDF2 \|MSK12 \|vla-beta \|vlab	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	VLA5-Alpha5与VLA5-BETA相互作用。	绑定	1690718\|1693624 \|3546305
ITGB5	FLJ26658	整合素，beta 5	-	HPRD	7592829 \| 11462216
L1CAM	CAML1 \| CD171 \| HSAS \| HSAS1 \| MASA \| MIC5 \| N-CAML1 \| S10 \| SPG1	L1细胞粘附分子	-	HPRD,BioGRID	10871287
Nisch	FLJ14425 \|FLJ40413 \|FLJ90519 \|I-1 \|iras \|KIAA0975	Nischarin	-	HPRD	12868002\|15028619
PECAM1	CD31 \| PECAM-1	血小板/内皮细胞粘附分子	-	HPRD	10982404
SPP1	BNSP \| BSPI \| ETA-1 \| MGC110940 \| OPN	分泌的磷蛋白1	-	HPRD,BioGRID	7592829
跨国公司	HXB \| MGC167029 \| TN	tenascin C	-	HPRD	9314546

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg焦点粘附	201	138	All SZGR 2.0 genes in this pathway
KEGG ECM受体相互作用	84	53	All SZGR 2.0 genes in this pathway
KEGG造血细胞谱系	88	60	All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节	216	144	All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM	85	65	All SZGR 2.0 genes in this pathway
KEGG心律失常右心肌病ARVC	76	59	All SZGR 2.0 genes in this pathway
KEGG扩张心肌病	92	68	All SZGR 2.0 genes in this pathway
ST整合素信号通路	82	62	All SZGR 2.0 genes in this pathway
PID Integin1途径	66	44	All SZGR 2.0 genes in this pathway
PID整合素CS途径	26	16	All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY	49	34	All SZGR 2.0 genes in this pathway
PID血管生成素受体途径	50	41	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID Syndecan 4途径	32	25	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
PID Syndecan 2途径	33	27	All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY	25	16	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
反应组细胞表面相互作用在血管壁	91	65	All SZGR 2.0 genes in this pathway
Reactome整合素细胞表面相互作用	79	48	All SZGR 2.0 genes in this pathway
Reactome Axon指导	251	188	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1	34	25	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN	162	116	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应	770	415	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
LA MEN1目标	24	15	All SZGR 2.0 genes in this pathway
洛佩兹MBD目标	957	597	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 240 MCF10A	57	36	All SZGR 2.0 genes in this pathway
宁慢性阻塞性肺疾病	157	105	All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN	85	67	All SZGR 2.0 genes in this pathway
NPM1本地化的Alcalay AML	140	83	All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN	162	102	All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70	67	33	All SZGR 2.0 genes in this pathway
Petrova Prox1靶向DN	64	38	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS RESPONSE	35	28	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP	56	35	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C5	21	11	All SZGR 2.0 genes in this pathway
伯顿成生成2	72	52	All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1	39	26	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 8HR	39	31	All SZGR 2.0 genes in this pathway
GHO ATF5 TARGETS DN	16	10	All SZGR 2.0 genes in this pathway
ITO PTTG1 TARGETS DN	9	7	All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY DN	58	39	All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE UP	81	53	All SZGR 2.0 genes in this pathway
冬季缺氧metagene	242	168	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟D	68	44	All SZGR 2.0 genes in this pathway
张TLX目标36hr	221	150	All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MILI假足趋化性DN	457	302	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
Boyault肝癌子类G2	27	17	All SZGR 2.0 genes in this pathway
Yamanaka胶质母细胞瘤生存	11	7	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
Wang对GSK3抑制剂SB216763 DN的响应	374	217	All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2	37	27	All SZGR 2.0 genes in this pathway
Bruins通过TP53组A的UVC响应	898	516	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移7	403	240	All SZGR 2.0 genes in this pathway
ERBB2的611CTF同工型的PEDERSEN目标	76	45	All SZGR 2.0 genes in this pathway
wakabayashi脂肪形成PPARG绑定8D	658	397	All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时	199	143	All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES	462	273	All SZGR 2.0 genes in this pathway
通过p38完成的phong TNF响应	227	151	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL PROGENITOR DN	14	9	All SZGR 2.0 genes in this pathway
Zwang仅通过第二EGF脉冲瞬时向上	1725	838	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-128	189	196	1A，M8	hsa-miR-128a	ucacagugaaccggucuuuu
miR-128	189	196	1A，M8	hsa-miR-128b	ucacagugaaccggucuuc
mir-148/152	902	909	1A，M8	hsa-miR-148a	ucagugcacuacaacuuugu
				HSA-MIR-152^brain	UCAGUGCAUGACACUUGGG
				hsa-miR-148b	ucagugcaucacacaacuuugu
mir-25/32/92/363/367	989	996	1A，M8	hsa-miR-25^brain	Cauugcacuugucucggucuga
				hsa-miR-32	uauugcacauacuaaguugc
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				HSA-MIR-367	Aauugcacuuuagcaaugga
				hsa-miR-92b^SZ	uauugcacucgucccgcgcuc
miR-26	134	141	1A，M8	HSA-MIR-26A^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	134	141	1A，M8	HSA-MIR-26B^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	190	197	1A，M8	HSA-MIR-27A^brain	uucacaguggcuaaguuccgc
miR-27	190	197	1A，M8	HSA-MIR-27B^brain	UUCACAGUGGCUAAGUUCUGC
mir-30-5p	205	212	1A，M8	HSA-MIR-30A-5P	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-31	405	411	1A	hsa-miR-31	Aggcaagaugcuggcauagcug
mir-326	409	415	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
mir-328	141	147	M8	hsa-miR-328^brain	cuggcccucugccuuccgu

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:itga5