Gene Page:ITGAL

Summary?
GeneID 3683
Symbol ITGAL
Synonyms CD11A|LFA-1|LFA1A
Description integrin subunit alpha L
Reference MIM:153370|HGNC:HGNC:6148|Ensembl:ENSG00000005844|HPRD:01079|Vega:OTTHUMG00000176964
Gene type protein-coding
Map location 16p11.2
Pascal p-value 0.005

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01775
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZNF365 0.93 0.89
KCNQ5 0.93 0.87
ARHGAP26 0.92 0.79
KCNA2 0.91 0.77
KCNH1 0.91 0.73
STXBP5L 0.91 0.81
REPS2 0.91 0.88
LUZP1 0.91 0.77
IQSEC1 0.91 0.83
HLF 0.90 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.52 -0.61
AC006276.2 -0.50 -0.50
NME4 -0.46 -0.56
RPL35 -0.46 -0.57
C9orf46 -0.46 -0.47
RPLP1 -0.45 -0.53
RPL36 -0.45 -0.54
TBC1D10A -0.44 -0.33
RAB13 -0.44 -0.56
RPL12 -0.44 -0.46

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000287 magnesium ion binding IEA -
GO:0004872 receptor activity IEA -
GO:0005509 calcium ion binding IEA -
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 12845325|15728350
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007155 cell adhesion IEA -
GO:0007155 cell adhesion NAS 8103515
GO:0007229 integrin-mediated signaling pathway IEA -
GO:0007165 signal transduction NAS 8103515
GO:0006954 inflammatory response NAS 8103515
GO:0006928 cell motion TAS 10477596
GO:0007159 leukocyte adhesion IEA -
: 0022409 positive regulation of cell-cell adhesion IEA -
GO:0042102 positive regulation of T cell proliferation IEA -
GO:0050850 positive regulation of calcium-mediated signaling IEA -
GO:0050798 activated T cell proliferation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0001772 immunological synapse IEA Synap (GO term level: 7) -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0009897 external side of plasma membrane IEA -
GO:0005886 plasma membrane EXP 11857637
GO:0008305 integrin complex IEA -
GO:0008305 integrin complex NAS 8103515

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL ADHESION MOLECULES CAMS 134 93 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 118 78 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 73 58 All SZGR 2.0 genes in this pathway
BIOCARTA GRANULOCYTES PATHWAY 14 9 All SZGR 2.0 genes in this pathway
BIOCARTA LYM PATHWAY 11 6 All SZGR 2.0 genes in this pathway
BIOCARTA BLYMPHOCYTE PATHWAY 11 8 All SZGR 2.0 genes in this pathway
BIOCARTA LAIR PATHWAY 17 12 All SZGR 2.0 genes in this pathway
BIOCARTA CTL PATHWAY 15 11 All SZGR 2.0 genes in this pathway
BIOCARTA MONOCYTE PATHWAY 11 5 All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY 14 11 All SZGR 2.0 genes in this pathway
BIOCARTA THELPER PATHWAY 14 11 All SZGR 2.0 genes in this pathway
PID INTEGRIN CS PATHWAY 26 16 All SZGR 2.0 genes in this pathway
PID INTEGRIN2 PATHWAY 29 18 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 34 All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 70 37 All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 91 65 All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 79 48 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187 115 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 161 93 All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION 45 34 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP 47 38 All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 64 47 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 UP 45 29 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP 66 47 All SZGR 2.0 genes in this pathway
NUMATA CSF3 SIGNALING VIA STAT3 22 17 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 128 90 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 36 24 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 63 44 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299 167 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
BERNARD PPAPDC1B TARGETS DN 58 39 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200 115 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 101 66 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway