Gene Page:ITGB5

Summary?
GeneID 3693
Symbol ITGB5
Synonyms -
Description integrin subunit beta 5
Reference MIM:147561|HGNC:HGNC:6160|Ensembl:ENSG00000082781|HPRD:00949|Vega:OTTHUMG00000159432
Gene type protein-coding
Map location 3q21.2
Pascal p-value 0.045
Sherlock p-value 0.584

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0708

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PIGZ 0.81 0.84
ABCG4 0.80 0.82
TAPBP 0.80 0.78
DNASE1L1 0.79 0.81
MYADM 0.79 0.78
SLC6A7 0.79 0.76
PPAPDC3 0.78 0.79
PRRT3 0.78 0.81
AC135048.1 0.78 0.79
SYNGR1 0.77 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SNRPG -0.41 -0.51
GTF3C6 -0.41 -0.41
ANP32C -0.41 -0.43
FAM36A -0.40 -0.37
RBMX2 -0.39 -0.39
C9orf46 -0.39 -0.39
RPL38 -0.39 -0.49
RPS20 -0.39 -0.46
RPS25P8 -0.38 -0.43
RPL35A -0.38 -0.42

Section III. Gene Ontology annotation

Molecular function 去你rm Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0005178 integrin binding IEA -
GO:0005515 protein binding IEA -
Biological process 去你rm Evidence Neuro keywords PubMed ID
GO:0007160 cell-matrix adhesion IEA -
GO:0007155 cell adhesion IEA -
GO:0007229 integrin-mediated signaling pathway IEA -
Cellular component 去你rm Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0008305 integrin complex IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ANXA5 ANX5 | ENX2 | PP4 annexin A5 - HPRD,BioGRID 12769841
CYR61 CCN1 | GIG1 | IGFBP10 cysteine-rich, angiogenic inducer, 61 - HPRD,BioGRID 11287419
GNB2L1 Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 - HPRD 9442085
ITGA5 CD49e | FNRA | VLA5A integrin, alpha 5 (fibronectin receptor, alpha polypeptide) - HPRD 7592829|11462216
ITGAV CD51 | DKFZp686A08142 | MSK8 | VNRA integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) Integrin-alphaV interacts with integrin-beta5. BIND 1694173
ITGAV CD51 | DKFZp686A08142 | MSK8 | VNRA integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) ITGAV (alphaV) interacts with ITGB5 (beta5). BIND 12459484
ITGAV CD51 | DKFZp686A08142 | MSK8 | VNRA integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) - HPRD,BioGRID 7689573
ITGB1 CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) - HPRD 11462216
ITGB3BP CENP-R | CENPR | HSU37139 | NRIF3 | TAP20 整合素β3结合蛋白(beta3-endonexin) in vivo BioGRID 10579726
LTBP1 MGC163161 latent transforming growth factor beta binding protein 1 - HPRD,BioGRID 12358597
LTBP3 DKFZp586M2123 | FLJ33431 | FLJ39893 | FLJ42533 | FLJ44138 | LTBP-3 | LTBP2 | pp6425 latent transforming growth factor beta binding protein 3 - HPRD,BioGRID 12358597
MYO10 FLJ10639 | FLJ21066 | FLJ22268 | FLJ43256 | KIAA0799 | MGC131988 myosin X Integrin-beta-5 interacts with Myo10. This interaction was modeled on a demonstrated interaction between human integrin-beta-5 and mouse Myo10. BIND 15156152
P2RY2 HP2U | MGC20088 | MGC40010 | P2RU1 | P2U | P2U1 | P2UR | P2Y2 | P2Y2R purinergic receptor P2Y, G-protein coupled, 2 - HPRD,BioGRID 11331301
PAK4 - p21 protein (Cdc42/Rac)-activated kinase 4 - HPRD,BioGRID 12356872
PTK2 FADK | FAK | FAK1 | pp125FAK PTK2 protein tyrosine kinase 2 Affinity Capture-Western
Reconstituted Complex		 BioGRID 11927607
TENC1 C1-TEN | C1TEN | DKFZp686D13244 | FLJ16320 | KIAA1075 | TNS2 tensin like C1 domain containing phosphatase (tensin 2) - HPRD 12606711
ZBTB17 MIZ-1 | ZNF151 | ZNF60 | pHZ-67 zinc finger and BTB domain containing 17 - HPRD,BioGRID 12356872


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG ECM RECEPTOR INTERACTION 84 53 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 76 59 All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 92 68 All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 82 63 All SZGR 2.0 genes in this pathway
PID INTEGRIN CS PATHWAY 26 16 All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY 42 30 All SZGR 2.0 genes in this pathway
PID INTEGRIN5 PATHWAY 17 9 All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 59 45 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 76 48 All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS 79 48 All SZGR 2.0 genes in this pathway
REACTOME MUSCLE CONTRACTION 48 24 All SZGR 2.0 genes in this pathway
REACTOME SMOOTH MUSCLE CONTRACTION 25 14 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285 181 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169 118 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204 140 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 139 76 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A DN 90 61 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
WOTTON RUNX TARGETS UP 21 14 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164 118 All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 66 37 All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME DN 17 9 All SZGR 2.0 genes in this pathway
霁转移STK11压抑 27 17 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN 52 34 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 66 47 All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP 140 83 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 13Q14 DELETION 24 18 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 114 84 All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS DN 30 21 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162 102 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 36 24 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C6 39 27 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN 76 57 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN 80 56 All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 58 43 All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 84 58 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C3 14 10 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
LEIN ASTROCYTE MARKERS 42 35 All SZGR 2.0 genes in this pathway
LEIN CHOROID PLEXUS MARKERS 103 61 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160 103 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO 38 24 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA DN 100 63 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 51 32 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181 106 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP 47 38 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 87 66 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 88 68 All SZGR 2.0 genes in this pathway
RAGHAVACHARI PLATELET SPECIFIC GENES 70 46 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS 25 15 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway