基因Page:ITK
概括?
| 基因ID | 3702 |
| Symbol | ITK |
| 同义词 | EMT|LPFS1|LYK|PSCTK2 |
| 描述 | IL2诱导T细胞激酶 |
| 参考 | MIM：186973|HGNC:HGNC:6171|Ensembl:ENSG00000113263|HPRD:01746|Vega:OTTHUMG00000130245 |
| 基因type | protein-coding |
| 地图位置 | 5q31-q32 |
| Pascal p-value | 0.055 |
数据源中的基因
| 基因set name | 基因组方法 | 描述 | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | 高通量文献搜索 | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | 基因组扫描荟萃分析 | Psr: 0.0032 | |
| GSMA_IIE | 基因组扫描荟萃分析（欧洲官方样品） | PSR：0.01718 | |
| GSMA_IIA | 基因组扫描荟萃分析(All samples) | PSR：0.00459 | |
| 文学 | 高通量文献搜索 | Co-occurancewith Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| 网络 | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | Contribution to shortest path in PPI network: 0.0385 |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
基因ral gene expression (GTEx)
基因expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| 基因 | Pearson's Correlation | Spearman's Correlation |
| RAD23A | 0.76 | 0.79 |
| Thop1 | 0.74 | 0.77 |
| DVL1 | 0.74 | 0.75 |
| AKT1S1 | 0.74 | 0.74 |
| PIM3 | 0.74 | 0.79 |
| TFE3 | 0.73 | 0.73 |
| AL355312.3 | 0.73 | 0.78 |
| CXXC5 | 0.72 | 0.72 |
| MYPOP | 0.72 | 0.75 |
| AL355987.1 | 0.72 | 0.74 |
| Top 10 negatively co-expressed genes | ||
| 基因 | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.41 | -0.24 |
| FAM159B | -0.38 | -0.45 |
| AL050337.1 | -0.36 | -0.27 |
| AF347015.18 | -0.35 | -0.23 |
| C1orf54 | -0.35 | -0.22 |
| AC135724.1 | -0.34 | -0.30 |
| SYCP3 | -0.34 | -0.31 |
| CLEC2B | -0.34 | -0.19 |
| AF347015.8 | -0.33 | -0.22 |
| MT-ATP8 | -0.33 | -0.22 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | 核苷酸结合 | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005524 | ATP binding | IEA | - | |
| 去：0004715 | non-membrane spanning protein tyrosine kinase activity | 塔斯 | 8364206 | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0016301 | kinase activity | IEA | - | |
| GO:0046872 | 金属离子结合 | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006468 | 蛋白氨基酸磷酸化 | IEA | - | |
| GO:0007242 | intracellular signaling cascade | IEA | - | |
| GO:0006968 | 蜂窝防御反应 | 塔斯 | 8364206 | |
| 细胞分量 | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0005829 | cytosol | EXP | 11048639|17652306 | |
| GO:0005886 | plasma membrane | IEA | - |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | - | HPRD，Biogrid | 8810341 |
| CD2 | SRBC | T11 | CD2molecule | Affinity Capture-Western | BioGRID | 9677430 |
| CD28 | MGC138290 | Tp44 | CD28 molecule | - | HPRD | 10586033 |
| FYN | MGC45350 |SLK |syn | FYN oncogene related to SRC, FGR, YES | - | HPRD，Biogrid | 8810341 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD，Biogrid | 10636929 |
| HNRNPK | CSBP | FLJ41122 | HNRPK | TUNP | 异质核核糖核蛋白K | ITK与HNRNPK相互作用。这种相互作用是在小鼠ITK和人HNRNPK之间证明的相互作用上建模的。 | BIND | 8810341 |
| HNRNPK | CSBP | FLJ41122 | HNRPK | TUNP | 异质核核糖核蛋白K | - | HPRD，Biogrid | 8810341 |
| ITK | EMT | LYK | MGC126257 | MGC126258 | PSCTK2 | IL2-inducible T-cell kinase | Biochemical Activity | BioGRID | 12163161 |
| KHDRBS1 | FLJ34027 |SAM68 |p62 | KH domain containing, RNA binding, signal transduction associated 1 | - | HPRD，Biogrid | 8810341|8985255 |
| KPNA1 | IPOA5 | NPI-1 | RCH2 | SRP1 | 核桃蛋白α1（importin alpha 5） | - | HPRD | 11581171 |
| KPNA2 | IPOA1 |qip2 |RCH1 |srp1alpha | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | Affinity Capture-Western Reconstituted Complex |
BioGRID | 11581171 |
| KPNA2 | IPOA1 |qip2 |RCH1 |srp1alpha | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | Itk interacts with and phosphorylates Rch1-alpha. | BIND | 11581171 |
| LAT | lat1 |pp36 | linker for activation of T cells | - | HPRD | 10506192|12186560 |
| LAT | lat1 |pp36 | linker for activation of T cells | Affinity Capture-Western Biochemical Activity |
BioGRID | 10506192|12186560 |
| LCP2 | SLP-76 | SLP76 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | - | HPRD，Biogrid | 10636929 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | Affinity Capture-Western Biochemical Activity Reconstituted Complex |
BioGRID | 10586033|12163161 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD | 10586033|12163161 |
| PPIA | cypa |Cyph |MGC117158 |MGC12404 |MGC23397 | peptidylprolyl isomerase A (cyclophilin A) | - | HPRD，Biogrid | 11830645 |
| SOCS1 | 顺式1 |cish1 |jab |SOCS-1 |SSI-1 |SSI1 |提示3 | suppressor of cytokine signaling 1 | SOCS1与ITK互动。这种相互作用是基于未指定物种的小鼠SOCS1和ITK之间的相互作用进行建模的。 | BIND | 10022833 |
| SOCS1 | 顺式1 |cish1 |jab |SOCS-1 |SSI-1 |SSI1 |提示3 | suppressor of cytokine signaling 1 | - | HPRD，Biogrid | 10022833 |
| SRC | ASV |src1 |C-SRC |P60-SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Reconstituted Complex | BioGRID | 10636929 |
| WAS | IMD2 | THC | WASP | Wiskott-Aldrich综合征（湿疹 - 肉毒细胞减少症） | - | HPRD，Biogrid | 8810341 |
V.途径注释
| Pathway name | Pathway size | ＃szgr 2.0基因 | Info |
|---|---|---|---|
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | 该途径中的所有SZGR 2.0基因 |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | 108 | 89 | 该途径中的所有SZGR 2.0基因 |
| KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 118 | 78 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA CTLA4 PATHWAY | 21 | 18 | 该途径中的所有SZGR 2.0基因 |
| St T细胞信号转导 | 45 | 33 | 该途径中的所有SZGR 2.0基因 |
| PID FCER1 PATHWAY | 62 | 43 | 该途径中的所有SZGR 2.0基因 |
| PID TCR PATHWAY | 66 | 51 | 该途径中的所有SZGR 2.0基因 |
| PID PI3KCI PATHWAY | 49 | 40 | 该途径中的所有SZGR 2.0基因 |
| REACTOME TCR SIGNALING | 54 | 46 | 该途径中的所有SZGR 2.0基因 |
| REACTOME GENERATION OF SECOND MESSENGER MOLECULES | 27 | 25 | 该途径中的所有SZGR 2.0基因 |
| Reactome免疫系统 | 933 | 616 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | 该途径中的所有SZGR 2.0基因 |
| 斋丁嫩造血干细胞DN | 226 | 132 | 该途径中的所有SZGR 2.0基因 |
| Lindgren膀胱癌簇2B | 392 | 251 | 该途径中的所有SZGR 2.0基因 |
| FARMER BREAST CANCER CLUSTER 1 | 44 | 23 | 该途径中的所有SZGR 2.0基因 |
| XU HGF靶向Akt1 DN抑制 | 95 | 58 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | 该途径中的所有SZGR 2.0基因 |
| SU THYMUS | 20 | 12 | 该途径中的所有SZGR 2.0基因 |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | 该途径中的所有SZGR 2.0基因 |
| 由Foxp3绑定的Marson未刺激 | 1229 | 713 | 该途径中的所有SZGR 2.0基因 |
| MARSON FOXP3 TARGETS STIMULATED UP | 29 | 19 | 该途径中的所有SZGR 2.0基因 |
| Marson Foxp3核心直接目标 | 19 | 14 | 该途径中的所有SZGR 2.0基因 |
| KONDO PROSTATE CANCER WITH H3K27ME3 | 196 | 93 | 该途径中的所有SZGR 2.0基因 |
| FINETTI BREAST CANCER KINOME GREEN | 16 | 14 | 该途径中的所有SZGR 2.0基因 |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | 该途径中的所有SZGR 2.0基因 |
| WORSCHECH TUMOR REJECTION UP | 56 | 32 | 该途径中的所有SZGR 2.0基因 |
| 乳腺癌萧述三腔的DN | 564 | 326 | 该途径中的所有SZGR 2.0基因 |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | 该途径中的所有SZGR 2.0基因 |
| Firestein增殖 | 175 | 125 | 该途径中的所有SZGR 2.0基因 |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | 该途径中的所有SZGR 2.0基因 |
| BOYLAN MULTIPLE MYELOMA C D DN | 252 | 155 | 该途径中的所有SZGR 2.0基因 |
| Lee区分T淋巴细胞 | 200 | 115 | 该途径中的所有SZGR 2.0基因 |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | 该途径中的所有SZGR 2.0基因 |
| MARSON FOXP3 TARGETS DN | 54 | 38 | 该途径中的所有SZGR 2.0基因 |
| Boylan多发性骨髓瘤PCA1 UP | 101 | 66 | 该途径中的所有SZGR 2.0基因 |
| KASLER HDAC7 TARGETS 1 UP | 194 | 133 | 该途径中的所有SZGR 2.0基因 |
| BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE | 151 | 86 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
| miRNA family | Target position | mirna id | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| mir-155 | 69 | 75 | m8 | hsa-miR-155 | UUAAUGCUAAUCGUGAUAGGGG |