Gene Page:ITPR3

Summary?
GeneID 3710
Symbol ITPR3
Synonyms IP3R|IP3R3
Description inositol 1,4,5-trisphosphate receptor type 3
Reference MIM:147267|HGNC:HGNC:6182|Ensembl:ENSG00000096433|HPRD:00926|Vega:OTTHUMG00000014532
Gene type protein-coding
Map location 6p21
Pascal p-value 6.02E-7
Sherlock p-value 0.61
Fetal beta 0.403
eGene Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4314462 chr5 152310797 ITPR3 3710 0.02 trans
rs7081666 chr10 47673800 ITPR3 3710 0.07 trans
rs17244419 chr14 97171074 ITPR3 3710 0.12 trans
rs1888534 chr21 46750189 ITPR3 3710 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CCT3 0.97 0.95
IGBP1 0.96 0.95
CCT6A 0.96 0.96
CCT7 0.96 0.95
ILF2 0.95 0.94
TEX10 0.95 0.93
SNRNP40 0.95 0.94
CCT8 0.95 0.96
TCP1 0.95 0.94
EIF3H 0.95 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.73 -0.86
AF347015.33 -0.73 -0.87
HLA-F -0.73 -0.81
AF347015.27 -0.73 -0.85
AF347015.31 -0.72 -0.85
AF347015.8 -0.71 -0.85
FXYD1 -0.70 -0.85
MT-CYB -0.70 -0.84
TINAGL1 -0.70 -0.79
IFI27 -0.69 -0.84

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005529 sugar binding IEA -
GO:0005509 calcium ion binding IEA -
GO:0005515 protein binding IEA -
GO:0005262 calcium channel activity IEA -
GO:0005216 ion channel activity IEA -
GO:0005220 inositol 1,4,5-triphosphate-sensitive calcium-release channel activity IEA -
GO:0008095 inositol-1,4,5-triphosphate receptor activity TAS 8288584
GO:0015085 钙离子跨膜转运体活动 TAS 8288584
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007165 signal transduction TAS 8288584
GO:0006816 calcium ion transport IEA -
GO:0006811 ion transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005783 endoplasmic reticulum TAS 8288584
GO:0016021 integral to membrane IEA -
GO:0005903 brush border TAS 8288584
GO:0005886 plasma membrane TAS 10828023

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CABP1 CALBRAIN | HCALB_BR calcium binding protein 1 - HPRD,BioGRID 12032348|14685260
ITPR1 INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16 inositol 1,4,5-triphosphate receptor, type 1 in vivo BioGRID 7559486
OPRS1 FLJ25585 | MGC3851 | SIGMAR1 | SR-BP1 opioid receptor, sigma 1 - HPRD,BioGRID 11149946
TRPC1 HTRP-1 | MGC133334 | MGC133335 | TRP1 瞬时受体电位阳离子通道,subfamily C, member 1 - HPRD,BioGRID 10980191|11290752
TRPC2 - 瞬时受体电位阳离子通道,subfamily C, member 2 (pseudogene) Reconstituted Complex BioGRID 11290752
TRPC3 TRP3 瞬时受体电位阳离子通道,subfamily C, member 3 - HPRD 15623527
TRPC3 TRP3 瞬时受体电位阳离子通道,subfamily C, member 3 Reconstituted Complex BioGRID 11290752
TRPC3 TRP3 瞬时受体电位阳离子通道,subfamily C, member 3 - HPRD 11524429
TRPC4 HTRP4 | MGC119570 | MGC119571 | MGC119572 | MGC119573 | TRP4 瞬时受体电位阳离子通道,subfamily C, member 4 Reconstituted Complex
Two-hybrid		 BioGRID 11163362|11290752
TRPC5 TRP5 瞬时受体电位阳离子通道,subfamily C, member 5 - HPRD,BioGRID 11290752
TRPC6 FLJ11098 | FLJ14863 | FSGS2 | TRP6 瞬时受体电位阳离子通道,subfamily C, member 6 - HPRD,BioGRID 11290752
TRPC7 TRP7 瞬时受体电位阳离子通道,subfamily C, member 7 Reconstituted Complex BioGRID 11290752
TRPM2 EREG1 | KNP3 | LTRPC2 | MGC133383 | NUDT9H | NUDT9L1 | TRPC7 瞬时受体电位阳离子通道,subfamily M, member 2 - HPRD 11290752


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 76 56 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG TASTE TRANSDUCTION 52 28 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169 110 All SZGR 2.0 genes in this pathway
ST WNT CA2 CYCLIC GMP PATHWAY 20 14 All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY 35 29 All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 45 37 All SZGR 2.0 genes in this pathway
ST ADRENERGIC 36 29 All SZGR 2.0 genes in this pathway
ST GAQ PATHWAY 28 22 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN B LYMPHOCYTES 36 31 All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 46 38 All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY 27 25 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
意图CTOME DAG AND IP3 SIGNALING 32 25 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
意图CTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 29 24 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
意图CTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
意图CTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
意图CTOME INTEGRATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
意图CTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
意图CTOME PLC BETA MEDIATED EVENTS 43 32 All SZGR 2.0 genes in this pathway
意图CTOME ELEVATION OF CYTOSOLIC CA2 LEVELS 10 6 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
意图CTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
意图CTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 43 28 All SZGR 2.0 genes in this pathway
意图CTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
意图CTOME REGULATION OF INSULIN SECRETION 93 65 All SZGR 2.0 genes in this pathway
意图CTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
意图CTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
意图CTOME PHOSPHOLIPASE C MEDIATED CASCADE 54 40 All SZGR 2.0 genes in this pathway
意图CTOME EFFECTS OF PIP2 HYDROLYSIS 25 17 All SZGR 2.0 genes in this pathway
意图CTOME PLATELET HOMEOSTASIS 78 49 All SZGR 2.0 genes in this pathway
意图CTOME PLATELET CALCIUM HOMEOSTASIS 18 10 All SZGR 2.0 genes in this pathway
意图CTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
意图CTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
意图CTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
意图CTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 78 41 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR UP 35 20 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229 137 All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 127 79 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292 168 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164 118 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222 139 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
LIU SMARCA4 TARGETS 64 39 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 51 32 All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6 52 32 All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261 166 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191 123 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175 103 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 181 97 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 DN 45 30 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 112 65 All SZGR 2.0 genes in this pathway
ZWANG EGF PERSISTENTLY DN 61 36 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 243 249 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 756 762 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-142-3p 361 367 1A hsa-miR-142-3p UGUAGUGUUUCCUACUUUAUGGA