Gene Page:ARCN1

概括?
基因 372
Symbol ARCN1
Synonyms COPD
Description archain 1
Reference MIM:600820|HGNC:HGNC:649|Ensembl:ENSG00000095139|HPRD:02893|Vega:OTTHUMG00000166340
Gene type protein-coding
Map location 11q23.3
Pascal p-value 0.078
Sherlock p-value 0.154
Fetal beta -0.002
eGene Cerebellar Hemisphere

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis PSR：0.006
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C20orf3 0.90 0.86
LDOC1 0.89 0.86
GORASP2 0.89 0.89
FAM50B 0.89 0.88
MAEA 0.89 0.86
FARSA 0.89 0.86
WRNIP1 0.89 0.87
USP11 0.89 0.85
DHX30 0.89 0.87
PPP2R1A 0.88 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.77 -0.76
MT-CO2 -0.76 -0.72
AF347015.8 -0.74 -0.71
AF347015.33 -0.73 -0.71
AF347015.31 -0.73 -0.71
NOSTRIN -0.72 -0.70
MT-CYB -0.72 -0.69
AF347015.2 -0.71 -0.67
AF347015.26 -0.71 -0.69
AF347015.27 -0.70 -0.71

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0016044 membrane organization 经验 11031247
GO:0006810 运输 IEA -
GO:0006886 intracellular protein transport IEA -
GO:0006886 intracellular protein transport TAS 7782067
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 经验 11031247
GO:0016192 囊泡介导的运输 IEA -
GO:0048205 COPI coating of Golgi vesicle 经验 16956762
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane IEA -
GO:0005794 Golgi apparatus IEA -
GO:0005829 cytosol 经验 8533093|8599108
GO:0005737 cytoplasm IEA -
去：0016020 membrane IEA -
GO:0031410 cytoplasmic vesicle IEA -
GO:0030131 clathrin adaptor complex IEA -
GO:0030126 COPI vesicle coat ISS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME MEMBRANE TRAFFICKING 129 74 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 50 30 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165 106 All SZGR 2.0 genes in this pathway
kayo卡路里限制肌肉 95 64 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
肌肉中的罗马胰岛素靶标 442 263 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10 69 38 All SZGR 2.0 genes in this pathway
阿金所有障碍LIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242 146 All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS UP 53 39 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 2154 2161 1A,m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-125/351 1898 1904 1A hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain ucccugagacccuuaaccugug
miR-15/16/195/424/497 1157 1163 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-185 266 272 1A hsa-miR-185brain UGGAGAGAAAGGCAGUUC
miR-204/211 209 216 1A,m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
mir-370 251 258 1A,m8 hsa-miR-370brain GCCUGCUGGGGUGGAACCUGG
mir-374 2203 2209 1A hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-409-3p 2153 2159 m8 hsa-miR-409-3p CGAAUGUUGCUCGGUGAACCCCU
miR-9 1859 1865 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA