Gene Page:JUNB

Summary?
GeneID 3726
Symbol JUNB
Synonyms AP-1
Description jun B proto-oncogene
Reference MIM:165161|HGNC:HGNC:6205|Ensembl:ENSG00000171223|HPRD:01303|Vega:OTTHUMG00000180373
Gene type protein-coding
Map location 19p13.2
Pascal p-value 0.008
Fetal beta -1.979
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis 这个数据集包括2104探针/论文认定相关with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance患有精神分裂症keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg19123863 19 12902675 JUNB 3.59E-8 -0.011 1.05E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RGS8 0.82 0.83
NXPH1 0.81 0.86
CPNE4 0.81 0.75
AC068051.1 0.80 0.72
MID2 0.80 0.77
PDE5A 0.80 0.68
DNER 0.79 0.83
ACSL3 0.79 0.82
SYT9 0.79 0.50
SLC17A6 0.79 0.75
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.2 -0.39 -0.48
FXYD1 -0.38 -0.46
AF347015.31 -0.38 -0.49
AF347015.21 -0.37 -0.48
MT-CO2 -0.37 -0.50
AF347015.8 -0.37 -0.49
AC021016.1 -0.37 -0.47
AF347015.33 -0.36 -0.45
SAT1 -0.36 -0.53
S100A13 -0.36 -0.48

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BATF B-ATF | BATF1 | SFA-2 basic leucine zipper transcription factor, ATF-like - HPRD,BioGRID 8570175
BCL6 BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51 B-cell CLL/lymphoma 6 - HPRD,BioGRID 12165517
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset BRCA1 interacts with JunB. BIND 12080089
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset - HPRD,BioGRID 12080089
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 estrogen receptor 1 ER-alpha interacts with JunB. This interaction was modeled on a demonstrated interaction between human ER-alpha and mouse JunB. BIND 11477071
FOS AP-1 | C-FOS v-fos FBJ murine osteosarcoma viral oncogene homolog - HPRD 1406655|10764760
FOSB AP-1 | DKFZp686C0818 | G0S3 | GOS3 | GOSB | MGC42291 FBJ murine osteosarcoma viral oncogene homolog B - HPRD 12371906
FOSL1 FRA | FRA1 | fra-1 FOS-like antigen 1 - HPRD 12371906
FOSL1 FRA | FRA1 | fra-1 FOS-like antigen 1 Two-hybrid BioGRID 16189514
FOSL2 FLJ23306 | FRA2 FOS-like antigen 2 - HPRD 14499865
JDP2 JUNDM2 Jun dimerization protein 2 - HPRD 9154808
JUN AP-1 | AP1 | c-Jun jun oncogene c-Jun interacts with Jun B. BIND 15240010
JUNB AP-1 jun B proto-oncogene - HPRD 12371906
MAPK8 JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 mitogen-activated protein kinase 8 - HPRD,BioGRID 9405416
MAPK9 JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPK mitogen-activated protein kinase 9 Reconstituted Complex BioGRID 8945519
NFE2L1 FLJ00380 | LCR-F1 | NRF1 | TCF11 nuclear factor (erythroid-derived 2)-like 1 - HPRD 9872330
RP4-691N24.1 FLJ11792 | KIAA0980 | NLP | dJ691N24.1 ninein-like Two-hybrid BioGRID 16189514
SMAD3 DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 SMAD family member 3 - HPRD 10903323
SMAD3 DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 SMAD family member 3 Reconstituted Complex
Two-hybrid		 BioGRID 10220381
SMAD4 DPC4 | JIP | MADH4 SMAD family member 4 - HPRD,BioGRID 10220381


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA GATA3 PATHWAY 16 15 All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY 47 39 All SZGR 2.0 genes in this pathway
PID FRA PATHWAY 37 28 All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 59 43 All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 70 60 All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 47 40 All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY 29 23 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 27 17 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 38 26 All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352 181 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 63 42 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384 230 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
BILBAN B CLL LPL DN 42 25 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240 171 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176 123 All SZGR 2.0 genes in this pathway
NAGASHIMA EGF SIGNALING UP 58 40 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214 155 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164 122 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
GESERICK TERT TARGETS DN 21 16 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
CHASSOT SKIN WOUND 10 9 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 88 58 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 127 92 All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 116 62 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY 66 48 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309 199 All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 12P11 12 DN 30 16 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP 57 41 All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC UP 21 16 All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA DN 55 29 All SZGR 2.0 genes in this pathway
SASAI RESISTANCE TO NEOPLASTIC TRANSFROMATION 50 31 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP 47 38 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
HE PTEN TARGETS DN 7 6 All SZGR 2.0 genes in this pathway
AMIT DELAYED EARLY GENES 18 15 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 40 HELA 42 29 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 120 MCF10A 65 44 All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP 110 70 All SZGR 2.0 genes in this pathway
ROSS ACUTE MYELOID LEUKEMIA CBF 82 57 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197 110 All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 144 98 All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182 116 All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
DORSAM HOXA9 TARGETS DN 32 22 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165 100 All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 2 UP 14 13 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 101 76 All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA UP 42 24 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRACX UP 20 14 All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP 52 33 All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR 55 38 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP 71 49 All SZGR 2.0 genes in this pathway
LEONARD HYPOXIA 47 35 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP 89 59 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 2HR 51 36 All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 54 36 All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 77 57 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
SARTIPY BLUNTED BY INSULIN RESISTANCE UP 19 17 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G2 30 18 All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261 166 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS DN 39 30 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER UP 38 21 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP 102 64 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223 132 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP 52 41 All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN 50 35 All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212 128 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR UP 29 18 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR DN 43 32 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR DN 39 28 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR DN 40 29 All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING NOT VIA NFKB 22 16 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN UP 56 38 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway
ZHU SKIL TARGETS UP 20 14 All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206 127 All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE VIA TSC1 23 12 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 1HR UP 34 26 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199 143 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
DELACROIX RAR TARGETS UP 48 33 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A 53 34 All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP 63 43 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 128 81 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214 124 All SZGR 2.0 genes in this pathway