Gene Page:GSTK1

Summary?
GeneID 373156
Symbol GSTK1
Synonyms GST|GST 13-13|GST13|GST13-13|GSTK1-1|hGSTK1
Description glutathione S-transferase kappa 1
Reference MIM:602321|HGNC:HGNC:16906|Ensembl:ENSG00000197448|Vega:OTTHUMG00000152637
Gene type protein-coding
Map location 7q34
Pascal p-value 6.83E-4
Fetal beta -1.072
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.2287

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04503743 7 142960869 GSTK1 5.835E-4 -0.222 0.049 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004602 glutathione peroxidase activity IEA -
GO:0004364 glutathione transferase activity IEA -
GO:0016740 transferase activity IEA -
GO:0015035 protein disulfide oxidoreductase activity IEA -
GO:0042802 identical protein binding 新闻学会 17353931
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006749 glutathione metabolic process IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IDA 11256614
GO:0005739 mitochondrion IEA -
GO:0005743 mitochondrial inner membrane IEA -
GO:0005777 peroxisome IEA -
GO:0030288 outer membrane-bounded periplasmic space IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ATXN10 E46L | FLJ37990 | SCA10 ataxin 10 Affinity Capture-MS BioGRID 17353931
CYCS CYC | HCS cytochrome c, somatic Affinity Capture-MS BioGRID 17353931
DCTN1 DAP-150 | DP-150 | HMN7B | P135 dynactin 1 (p150, glued homolog, Drosophila) Affinity Capture-MS BioGRID 17353931
DDOST AGE-R1 | KIAA0115 | MGC2191 | OK/SW-cl.45 | OST | OST48 | WBP1 dolichyl-diphosphooligosaccharide-protein glycosyltransferase Affinity Capture-MS BioGRID 17353931
EFTUD2 DKFZp686E24196 | FLJ44695 | KIAA0031 | Snrp116 | Snu114 | U5-116KD elongation factor Tu GTP binding domain containing 2 Affinity Capture-MS BioGRID 17353931
EPPK1 EPIPL | EPIPL1 epiplakin 1 Affinity Capture-MS BioGRID 17353931
FANCI FLJ10719 | KIAA1794 Fanconi anemia, complementation group I Affinity Capture-MS BioGRID 17353931
HEATR2 FLJ20397 | FLJ25564 | FLJ31671 | FLJ39381 HEAT repeat containing 2 Affinity Capture-MS BioGRID 17353931
HNRNPM DKFZp547H118 | HNRNPM4 | HNRPM | HNRPM4 | HTGR1 | NAGR1 heterogeneous nuclear ribonucleoprotein M Affinity Capture-MS BioGRID 17353931
HRNR S100A16 | S100a18 hornerin Affinity Capture-MS BioGRID 17353931
HTR1B 5-HT1B | 5-HT1DB | HTR1D2 | HTR1DB | S12 5-hydroxytryptamine (serotonin) receptor 1B Affinity Capture-MS BioGRID 17353931
IARS FLJ20736 | IARS1 | ILRS | PRO0785 isoleucyl-tRNA synthetase Affinity Capture-MS BioGRID 17353931
IPO4 FLJ23338 | Imp4 | MGC131665 importin 4 Affinity Capture-MS BioGRID 17353931
KIAA1279 DKFZp586B0923 | KBP | TTC20 KIAA1279 Affinity Capture-MS BioGRID 17353931
KIAA1967 DBC-1 | DBC1 KIAA1967 Affinity Capture-MS BioGRID 17353931
LRPPRC CLONE-23970 | GP130 | LRP130 | LSFC leucine-rich PPR-motif containing Affinity Capture-MS BioGRID 17353931
MATR3 DKFZp686K0542 | DKFZp686K23100 | KIAA0723 | MGC9105 matrin 3 Affinity Capture-MS BioGRID 17353931
MCM7 CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146 minichromosome maintenance complex component 7 Affinity Capture-MS BioGRID 17353931
PDCD6IP AIP1 | Alix | DRIP4 | HP95 | MGC17003 programmed cell death 6 interacting protein Affinity Capture-MS BioGRID 17353931
RPN1 DKFZp686B16177 | OST1 | RBPH1 ribophorin I Affinity Capture-MS BioGRID 17353931
RPN2 RIBIIR | RPN-II | RPNII | SWP1 ribophorin II Affinity Capture-MS BioGRID 17353931
SEC63 ERdj2 | PRO2507 | SEC63L SEC63 homolog (S. cerevisiae) Affinity Capture-MS BioGRID 17353931
SLC3A2 4F2 | 4F2HC | 4T2HC | CD98 | CD98HC | MDU1 | NACAE 溶质家庭3(氢的催化剂和载体neutral amino acid transport), member 2 Affinity Capture-MS BioGRID 17353931
TSC22D1 DKFZp686O19206 | MGC17597 | RP11-269C23.2 | TGFB1I4 | TSC22 TSC22 domain family, member 1 Affinity Capture-MS BioGRID 17353931
XPO5 FLJ14239 | FLJ32057 | FLJ45606 | KIAA1291 exportin 5 Affinity Capture-MS BioGRID 17353931
ZW10 HZW10 | KNTC1AP | MGC149821 ZW10, kinetochore associated, homolog (Drosophila) Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLUTATHIONE METABOLISM 50 34 All SZGR 2.0 genes in this pathway
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 70 44 All SZGR 2.0 genes in this pathway
KEGG DRUG METABOLISM CYTOCHROME P450 72 47 All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 78 47 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 64 39 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 75 50 All SZGR 2.0 genes in this pathway
萨斯博士排毒帕特HWAY AND CARCINOGENESIS DN 13 11 All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 8Q24 DN 46 28 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
GUO HEX TARGETS DN 65 36 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 3MO DN 23 14 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO DN 21 12 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS DN 47 29 All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 88 56 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 79 54 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157 106 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428 246 All SZGR 2.0 genes in this pathway