基因页：KCNA1

概括?
基因ID 3736
Symbol KCNA1
同义词 aemk | ea1 | hbk1 | huk1 | kv1.1 | mbk1 | mk1 | rbk1
描述 potassium voltage-gated channel subfamily A member 1
参考 MIM:176260|HGNC：HGNC：6218|ENSEMBL：ENSG00000111262|HPRD:08885|Vega：Otthumg00000000444398
基因type protein-coding
地图位置 12p13.32
Pascal P值 0.005
Sherlock P值 0.872
Fetal beta -2.361
DMG 1（＃研究）
eGene 迈尔斯的顺式和跨性别
支持 EXCITABILITY

数据源中的基因
基因set name 基因组方法 描述 Info
简历：PGCNP 全基因组协会研究 GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
PMID:cooccur 高通量文献搜索 系统的年代earch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 高通量文献搜索 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

第一节遗传学和表观遗传学注释

@差异甲基化基因

探测 Chromosome Position 最近的基因 P (dis) beta（dis） FDR (dis) Study
CG26590537 12 5020202 KCNA1 -0.02 0.54 DMG:Nishioka_2013

@EQTL注释

SNP ID Chromosome Position eGene 基因Entrez ID PVALUE qvalue TSS distance eQTL type
RS17048849 chr2 129626025 KCNA1 3736 0.09 trans
rs2197597 chr2 129638077 KCNA1 3736 0 trans
rs2897468 chr2 129711721 KCNA1 3736 0.04 trans
rs12463708 chr2 149073943 KCNA1 3736 0.12 trans
rs16829545 chr2 151977407 KCNA1 3736 2.552E-4 trans
RS12509866 chr4 173017639 KCNA1 3736 0.01 trans
RS6903775 chr6 9420439 KCNA1 3736 0.17 trans
RS1020772 chr9 76532511 KCNA1 3736 0.19 trans
rs6537895 chr9 138318523 KCNA1 3736 0.02 trans
RS10761452 chr10 61847680 KCNA1 3736 0.19 trans
RS1344796 chr12 76397104 KCNA1 3736 0 trans
RS7488439 chr12 105155814 KCNA1 3736 0.08 trans
RS17036489 chr12 105292283 KCNA1 3736 0.15 trans
rs11068670 chr12 118182168 KCNA1 3736 0.02 trans
rs10850897 chr12 118196074 KCNA1 3736 0.02 trans
rs17081039 chr13 66841328 KCNA1 3736 0.15 trans
RS1298114 chr14 32382282 KCNA1 3736 0.13 trans
RS16955618 chr15 29937543 KCNA1 3736 3.785E-4 trans
rs6032295 chr20 44178138 KCNA1 3736 3.34e-4 trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

无法使用

基因expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 皮尔逊的相关性 Spearman's Correlation
CHRM1 0.93 0.90
C2orf55 0.90 0.79
ADAMTS8 0.89 0.77
Arhgef4 0.88 0.82
AC105206.1 0.87 0.86
KCNH3 0.87 0.82
DGKZ 0.87 0.83
CACNG3 0.87 0.90
PDE2A 0.86 0.87
grin1 0.86 0.79
前10个负共表达基因
基因 皮尔逊的相关性 Spearman's Correlation
HEBP2 -0.53 -0.64
Bcl7c -0.48 -0.52
C21orf57 -0.44 -0.41
C9orf46 -0.44 -0.40
RBMX2 -0.44 -0.41
exosc8 -0.44 -0.33
Dynlt1 -0.44 -0.45
FAM36A -0.42 -0.34
RPL23A -0.42 -0.39
UBE2L6 -0.42 -0.24

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
GO:0005244 voltage-gated ion channel activity IEA -
GO:0005249 voltage-gated potassium channel activity IEA -
GO:0005251 整流器钾通道活动延迟 塔斯 8845167
GO:0015079 potassium ion transmembrane transporter activity 塔斯 8845167
GO:0030955 potassium ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007268 突触传输 塔斯 neuron, Synap, Neurotransmitter (GO term level: 6) 7842011
GO:0006811 离子运输 IEA -
GO:0006813 钾离子运输 IEA -
GO:0006813 钾离子运输 塔斯 8845167
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0016020 膜 IEA -
GO:0016021 integral to membrane IEA -
去：0008076 电压门控钾通道复合物 IEA -
去：0008076 电压门控钾通道复合物 塔斯 8845167

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
Reactome神经元系统 279 221 该途径中的所有SZGR 2.0基因
Reactome电压门控钾通道 43 32 该途径中的所有SZGR 2.0基因
Reactome钾通道 98 68 该途径中的所有SZGR 2.0基因
ODONNELL TFRC TARGETS DN 139 76 该途径中的所有SZGR 2.0基因
SENESE HDAC1 TARGETS DN 260 143 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
Schlesinger H3K27me3在正常状态下甲基化的癌症 28 21 该途径中的所有SZGR 2.0基因
Benporath Suz12目标 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
与H3K27me3的Benporath ES 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH PRC2 TARGETS 652 441 该途径中的所有SZGR 2.0基因
LEE AGING NEOCORTEX UP 89 59 该途径中的所有SZGR 2.0基因
MAHAJAN RESPONSE TO IL1A UP 81 52 该途径中的所有SZGR 2.0基因
LIN NPAS4靶向DN 68 48 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
具有H3K4ME2和H3K27ME3的Meissner NPC HCP 349 234 该途径中的所有SZGR 2.0基因
黄成人组织茎模块 721 492 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
GOBERT CORE OLIGODENDROCYTE DIFFERENTIATION 40 28 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family 目标位置 mirna id miRNA seq
UTR start UTR end Match method
mir-10 4461 4467 1A HSA-MIR-10A uacccuguagauccgaauuugug
HSA-MIR-10B UACCCUGUAGAACCGAAUUUGU
mir-101 1033 1040 1A,m8 HSA-MIR-101 UACAGUACUGUGAUAACUGAAG
mir-124/506 1651年 1657年 m8 HSA-MIR-506 uaaggcacccuucugugaguaga
hsa-miR-124脑 UAAGGCACGCGGUGAAUGCC
mir-125/351 1273 1280 1A,m8 HSA-MIR-125B脑 UCCCUGAGACCCUAACUUGUGA
HSA-MIR-125A脑 UCCCUGAGACCCUUUAACCUGUG
mir-128 4588 4594 m8 HSA-MIR-128A UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128B UCACAGUGAACCGGUCUCUUUC
HSA-MIR-128A UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128B UCACAGUGAACCGGUCUCUUUC
mir-133 1316 1322 1A hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b uguguccccuucaaccagcua
mir-137 2897 2903 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
mir-144 1034 1040 1A hsa-miR-144 uacaguauagauguauguaguag
mir-153 5303 5310 1A,m8 hsa-miR-153 Uugcauagucacaaaaguga
mir-155 1108 1114 m8 hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG
mir-18 596 603 1A,m8 hsa-miR-18a UAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18b uaaggugcaucuagugcagua
mir-182 4269 4275 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
mir-186 1403 1409 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
mir-21 929 935 m8 HSA-MIR-21脑 uagcuuaucagacugauguuga
HSA-MIR-590 GAGCUUAUUCAUAAAAGUGCAG
mir-218 839 845 1A HSA-MIR-218脑 uugugcuugaucuaaccaugu
miR-221/222 3184 3190 1A HSA-MIR-221脑 AGCUACAUUGUCUGCUGGGUUUC
HSA-MIR-222脑 AGCUACAUCUGGCUACUGGGUCUC
miR-25/32/92/363/367 1467 1474 1A,m8 HSA-MIR-25脑 CAUUGCACUUGUCUCGGUCUGA
HSA-MIR-32 UAUUGCACAUUACUAAGUUGC
HSA-MIR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
HSA-MIR-92bSZ UAUUGCACUCGUCCCGGCCUC
mir-27 1791年 1797年 m8 hsa-miR-27a脑 UUCACAGUGGCUAAGUUCCGC
hsa-miR-27b脑 uucacaguggcuaaguucugc
miR-323 3231 3237 m8 HSA-MIR-323脑 GCACAUUACACGGUCGACCUCU
mir-34/449 4267 4273 1A HSA-MIR-34A脑 UGGCAGUGUCUUAGCUGGUUGUU
HSA-MIR-34C AGGCAGUGUAGUUAGCUGAUUGC
HSA-MIR-449 uggcaguguauuguagcuggu
HSA-MIR-449b Aggcaguguauuguuagcuggc
miR-342 1793年 1799年 1A HSA-MIR-342脑 UCUCACACAGAAAUCGCACCCGUC
mir-34b 3277 3284 1A,m8 HSA-MIR-34B UAGGCAGUGUCAUUAGCUGAUUG
mir-363 4592 4598 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-409-5p 4227 4234 1A,m8 hsa-miR-409-5p AGGUUACCCGAGCAACUUUGCA
miR-448 5304 5310 1A HSA-MIR-448 uugcauauguaggauguccccau
miR-452 4593 4599 m8 HSA-MIR-452 UguuugcaggaaacugagaC
miR-500 1465 1472 1A,m8 HSA-MIR-500 AUGCACCUGGGCAAGGAUUCUG
mir-542-3p 5323 5329 m8 HSA-MIR-542-3P ugugacauugauaacugaaa
miR-7 3448 3454 1A HSA-MIR-7SZ Uggaagacuaguuuuuguug
miR-9 3573 3580 1A,m8 HSA-MIR-9SZ ucuuuguuaucuagcuguauga
mir-93.hd/291-3p/294/295/302/372/373/520 3265 3271 1A HSA-MIR-93脑 AAAGUGCUGUUCGUGCAGGUAG
HSA-MIR-302A UAAGUGCUUCCAUGUUUUGGUGA
HSA-MIR-302B uaagugcuuccauguuuaguag
HSA-MIR-302C UAAGUGCUUCCAUGUUUCAGUGG
HSA-MIR-302D Uaagugcuauguugugugu
hsa-miR-372 aaagugcugcgacauuugagcgu
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
HSA-MIR-520A aaagugcuucccuuguggugu
HSA-MIR-520B AAAGUGCUUCCUUUUAGAGGG
HSA-MIR-520C AAAGUGCUUCCUUUUAGAGGGUU
HSA-MIR-520D AAAGUGCUUCUCUUUGGUGGGUU
miR-96 4269 4275 1A HSA-MIR-96脑 UUUGGCACUAGCACAUUUUUGC