Gene Page:KCND2

Summary?
GeneID 3751
Symbol KCND2
Synonyms KV4.2|RK5
Description potassium voltage-gated channel subfamily D member 2
Reference MIM:605410|HGNC:HGNC:6238|Ensembl:ENSG00000184408|HPRD:09254|Vega:OTTHUMG00000156989
Gene type protein-coding
Map location 7q31
Pascal p-value 0.641
Sherlock p-value 0.076
Fetal beta -1.097
DMG 1 (# studies)
Support EXCITABILITY
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0018

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25241964 7 119912723 KCND2 2.17E-8 -0.013 7.31E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EXOC4 0.88 0.92
SLC37A3 0.87 0.90
TMEM185A 0.87 0.89
GPR85 0.87 0.87
POLR1B 0.86 0.89
NCOA5 0.86 0.90
TDG 0.86 0.90
NKAIN2 0.86 0.82
TSPAN14 0.85 0.89
TBC1D14 0.85 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AIFM3 -0.67 -0.74
AF347015.31 -0.67 -0.81
FXYD1 -0.66 -0.82
MT-CO2 -0.66 -0.82
TSC22D4 -0.66 -0.76
HEPN1 -0.65 -0.73
C5orf53 -0.65 -0.70
HLA-F -0.65 -0.73
HSD17B14 -0.65 -0.76
S100B -0.65 -0.78

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 11287421
GO:0005515 protein binding NAS 11102480
GO:0005244 voltage-gated ion channel activity IEA -
GO:0005249 voltage-gated potassium channel activity NAS 11102480
GO:0008270 zinc ion binding IEA -
GO:0030955 potassium ion binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 11102480
GO:0001508 regulation of action potential TAS 11102480
GO:0006811 ion transport IEA -
GO:0006813 potassium ion transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0043197 dendritic spine NAS Synap, dendrite (GO term level: 7) 11102480
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0009986 cell surface IDA 12493773
GO:0008076 voltage-gated potassium channel complex IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME VOLTAGE GATED POTASSIUM CHANNELS 43 32 All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS 98 68 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP 73 47 All SZGR 2.0 genes in this pathway
KIM MYCL1 AMPLIFICATION TARGETS UP 13 11 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 116 79 All SZGR 2.0 genes in this pathway
SCHAEFFER前列腺癌发展48小时 487 286 All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU DN 83 69 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 79 62 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260 174 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3 206 108 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 126 83 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 137 85 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP 163 111 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 1598 1604 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-129-5p 341 347 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-140 158 164 m8 hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-149 1742 1748 1A hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-186 487 493 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429 693 699 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-205 458 464 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-218 236 242 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-324-3p 497 503 1A hsa-miR-324-3p CCACUGCCCCAGGUGCUGCUGG
miR-324-5p 655 661 m8 hsa-miR-324-5p CGCAUCCCCUAGGGCAUUGGUGU
miR-33 332 338 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-338 2412 2419 1A,m8 hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-362 2389 2395 1A hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
miR-363 615 621 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-539 645 652 1A,m8 hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
mir - 93. - hd / 291-3p/294/295/302/372/373/520 574 580 1A hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c UAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU