Gene Page:KCNJ2

概括?
GeneID 3759
Symbol KCNJ2
同义词 ATFB9|HHBIRK1|HHIRK1|IRK1|KIR2.1|LQT7|SQT3
描述 钾电源门控通道亚家族J成员2
参考 MIM:600681|HGNC:HGNC:6263|Ensembl:ENSG00000123700|HPRD：02815|Vega:OTTHUMG00000180351
Gene type protein-coding
Map location 17q24.3
Pascal p-value 0.725
Sherlock P值 0.083
度p-value DEG：ZHAO_2015：P = 2.48E-04：Q = 0.0872
Fetal beta -1.406

数据源中的基因
基因集名称 Method of gene set 描述 Info
CV:PGCnp Genome-wide Association Study GWAS
DEG：Zhao_2015 RNA测序分析 Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.
Network 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 0.0018

第一节遗传学和表观遗传学注释


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
THAP4 0.57 0.54
ATF5 0.57 0.57
PFKL 0.56 0.60
FTSJ2 0.56 0.55
RCCD1 0.56 0.60
POFUT2 0.56 0.59
ABCD1 0.56 0.59
C19orf61 0.55 0.58
TRAF2 0.55 0.58
STARD3 0.55 0.56
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.47 -0.51
MT-CO2 -0.46 -0.51
AF347015.27 -0.44 -0.49
AF347015.21 -0.43 -0.48
MT-CYB -0.43 -0.49
AF347015.33 -0.43 -0.47
AF347015.8 -0.42 -0.48
AF347015.2 -0.39 -0.46
AF347015.15 -0.39 -0.45
MYL3 -0.39 -0.43

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 11287423|12923176
GO:0005242 inward rectifier potassium channel activity 塔斯 7696590
GO:0005244 voltage-gated ion channel activity IEA -
GO:0030955 potassium ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006811 ion transport IEA -
GO:0006813 potassium ion transport 塔斯 7696590
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0016020 膜 IEA -
GO:0005887 质膜的积分 塔斯 7696590

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 该途径中的所有SZGR 2.0基因
REACTOME NEURONAL SYSTEM 279 221 该途径中的所有SZGR 2.0基因
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 该途径中的所有SZGR 2.0基因
通过GBETA伽马亚基对电压门控Ca2通道的反应组抑制 25 17 该途径中的所有SZGR 2.0基因
REACTOME GABA B RECEPTOR ACTIVATION 38 26 该途径中的所有SZGR 2.0基因
REACTOME GABA RECEPTOR ACTIVATION 52 40 该途径中的所有SZGR 2.0基因
REACTOME POTASSIUM CHANNELS 98 68 该途径中的所有SZGR 2.0基因
REACTOME INWARDLY RECTIFYING K CHANNELS 31 20 该途径中的所有SZGR 2.0基因
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 该途径中的所有SZGR 2.0基因
HORIUCHI WTAP TARGETS UP 306 188 该途径中的所有SZGR 2.0基因
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 该途径中的所有SZGR 2.0基因
Nuytten Nipp1靶向DN 848 527 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 该途径中的所有SZGR 2.0基因
HADDAD B LYMPHOCYTE PROGENITOR 293 193 该途径中的所有SZGR 2.0基因
NPM1的Verhaak AML突变 183 111 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 该途径中的所有SZGR 2.0基因
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR 37 22 该途径中的所有SZGR 2.0基因
HENDRICKS SMARCA4 TARGETS DN 53 34 该途径中的所有SZGR 2.0基因
在胰腺癌中被甲基化沉默的Sato 1 419 273 该途径中的所有SZGR 2.0基因
由Foxp3绑定的Marson未刺激 1229 713 该途径中的所有SZGR 2.0基因
BONCI TARGETS OF MIR15A AND MIR16 1 91 75 该途径中的所有SZGR 2.0基因
LABBE TGFB1 TARGETS DN 108 64 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
Mikkelsen MCV6 ICP，带有H3K4ME3和H3K27ME3 34 21 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF ICP WITH H3K4ME3 AND H3K27ME3 38 34 该途径中的所有SZGR 2.0基因
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 126 83 该途径中的所有SZGR 2.0基因
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN 37 26 该途径中的所有SZGR 2.0基因
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 137 85 该途径中的所有SZGR 2.0基因
Mikkelsen NPC ICP带有H3K4Me3 445 257 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 该途径中的所有SZGR 2.0基因
WANG MLL TARGETS 289 188 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
miR-124.1 366 373 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 366 372 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124脑 UAAGGCACGCGGUGAAUGCC
miR-132/212 2675 2681 m8 HSA-MIR-212SZ uaacagucuccagucacgccc
hsa-miR-132脑 uaacagucuacccaugggg
mir-135 1468 1474 1A hsa-miR-135a Uauggcuuuuuuuuccuauga
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-141/200a 455 461 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
mir-15/16/195/424/497 2160 2167 1A,m8 hsa-miR-15a脑 UAGCAGCACAUAAUGGUUUGUG
HSA-MIR-16脑 uagcagcacguaaauauuggcg
hsa-miR-15b脑 UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
HSA-MIR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
hsa-miR-15a脑 UAGCAGCACAUAAUGGUUUGUG
HSA-MIR-16脑 uagcagcacguaaauauuggcg
hsa-miR-15b脑 UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
HSA-MIR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-182 518 524 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-19 732 739 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
mir-193 545 552 1A,m8 hsa-miR-193a Aacuggccuacaaagucccag
hsa-miR-193b AACUGGCCCUCAAAGUCCCGCUUU
MiR-200BC/429 1447 1453 m8 HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C uaauacugccggguaaugaugg
HSA-MIR-429 uaauacuguguguguguguaaaaaccgu
mir - 219 3572 3578 m8 HSA-MIR-219脑 ugauuguccaaacgcaauucu
miR-26 3144 3151 1A,m8 hsa-miR-26a脑 Uucaaguaauccaggauaggc
hsa-miR-26bSZ uucaaguaauucaggauagguu
hsa-miR-26a脑 Uucaaguaauccaggauaggc
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-320 2725 2731 1A HSA-MIR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-410 3665 3671 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-431 357 363 m8 HSA-MIR-431 UGUCUUGCAGGCCGUCAUGCA
HSA-MIR-431 UGUCUUGCAGGCCGUCAUGCA
miR-455 203 210 1A,m8 HSA-MIR-455 UAUGUGCCUUUGGACUACAUCG
mir-495 2414 2420 m8 hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
mir-496 2504 2510 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-503 2161 2167 1A hsa-miR-503 uagcagcgggaacaguucugcag
hsa-miR-503 uagcagcgggaacaguucugcag
miR-505 457 464 1A,m8 hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
miR-7 3623 3629 m8 hsa-miR-7SZ Uggaagacuaguuuuuguug
miR-9 713 720 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
miR-96 518 524 1A hsa-miR-96脑 UUUGGCACUAGCACAUUUUUGC