Gene Page:KCNJ3

概括?
基因 3760
象征 KCNJ3
Synonyms GIRK1|KGA|KIR3.1
Description 钾电源门控通道亚家族j成员3
Reference MIM：601534|HGNC：HGNC：6264|Ensembl:ENSG00000162989|HPRD:03323|Vega：Otthumg00000131937
Gene type protein-coding
Map location 2q24.1
Pascal p-value 0.049
Fetal beta -2.018
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
Cortex
Support CANABINOID
EXCITABILITY
5-羟色胺

数据源中的基因
Gene set name Method of gene set Description Info
CV：GWASDB Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02395
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias 点击to show details

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23491599 2 155554688 KCNJ3 8.32E-5 -0.63 0.026 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TTBK1 0.90 0.91
MGAT3 0.87 0.90
NCLN 0.87 0.89
FBXL14 0.86 0.88
AARS2 0.86 0.88
TECPR1 0.86 0.88
MEGF8 0.86 0.88
CRTC1 0.85 0.88
MARK2 0.85 0.87
GAK 0.85 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.68 -0.66
AF347015.21 -0.68 -0.70
MT-CO2 -0.67 -0.65
AF347015.8 -0.66 -0.65
AL139819.3 -0.65 -0.68
AF347015.33 -0.65 -0.62
AF347015.27 -0.64 -0.65
MT-CYB -0.64 -0.63
FXYD1 -0.62 -0.60
AC021016.1 -0.62 -0.64

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005244 voltage-gated ion channel activity IEA -
GO:0015467 G蛋白激活了向内整流钾通道活性 TAS 8804710
GO:0030955 potassium ion binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0006811 ion transport IEA -
GO:0006813 potassium ion transport TAS 8804710
Cellular component GO term Evidence Neuro keywords PubMed ID
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -
GO:0008076 voltage-gated potassium channel complex TAS 8804710

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
ST G ALPHA I PATHWAY 35 29 该途径中的所有SZGR 2.0基因
ST ADRENERGIC 36 29 该途径中的所有SZGR 2.0基因
ST MYOCYTE AD PATHWAY 27 25 该途径中的所有SZGR 2.0基因
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 该途径中的所有SZGR 2.0基因
REACTOME NEURONAL SYSTEM 279 221 该途径中的所有SZGR 2.0基因
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 该途径中的所有SZGR 2.0基因
REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS 25 17 该途径中的所有SZGR 2.0基因
REACTOME GABA B RECEPTOR ACTIVATION 38 26 该途径中的所有SZGR 2.0基因
REACTOME GABA RECEPTOR ACTIVATION 52 40 该途径中的所有SZGR 2.0基因
REACTOME POTASSIUM CHANNELS 98 68 该途径中的所有SZGR 2.0基因
REACTOME INWARDLY RECTIFYING K CHANNELS 31 20 该途径中的所有SZGR 2.0基因
LIU PROSTATE CANCER DN 481 290 该途径中的所有SZGR 2.0基因
GOZGIT ESR1 TARGETS DN 781 465 该途径中的所有SZGR 2.0基因
MOHANKUMAR TLX1 TARGETS UP 414 287 该途径中的所有SZGR 2.0基因
Hatada甲基化在肺癌中 390 236 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP 89 51 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性4 307 185 该途径中的所有SZGR 2.0基因
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER LUMINAL B UP 172 109 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL DN 701 446 该途径中的所有SZGR 2.0基因
YAUCH HEDGEHOG SIGNALING PARACRINE UP 149 85 该途径中的所有SZGR 2.0基因
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 该途径中的所有SZGR 2.0基因
HOSHIDA LIVER CANCER SURVIVAL DN 113 76 该途径中的所有SZGR 2.0基因
VERHAAK GLIOBLASTOMA NEURAL 129 85 该途径中的所有SZGR 2.0基因
Dutertre雌二醇反应24小时DN 505 328 该途径中的所有SZGR 2.0基因
RAO BOUND BY SALL4 ISOFORM A 182 108 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 604 610 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-142-5p 550 556 m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
mir-25/32/92/363/367 229 235 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 Aauugcacuuuagcaaugga
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-30-5p 545 551 m8 HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-323 234 240 m8 hsa-miR-323brain gcacauuacggucgaccucu
mir-363 238 244 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
mir-365 16 22 1A hsa-miR-365 uaaugccccuaaaaaauccuuau
miR-369-3p 211 217 m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
mir-375 929 935 1A hsa-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-378* 44 50 1A hsa-miR-422b CUGGACUUGGAGUCAGAAGGCC
hsa-miR-422a CUGGACUUAGGGUCAGAAGGCC
miR-410 271 277 1A hsa-miR-410 aauauaacacagauggcugu