Gene Page:KCNK2

概括?
基因 3776
Symbol KCNK2
Synonyms K2p2.1|TPKC1|TREK|TREK-1|TREK1|hTREK-1c|hTREK-1e
Description potassium two pore domain channel subfamily K member 2
Reference MIM:603219|HGNC:HGNC:6277|Ensembl:ENSG00000082482|Vega：Otthumg0000000037017
Gene type protein-coding
Map location 1q41
Fetal beta 2.599
DMG 1 (# studies)

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Expression Meta-analysis of gene expression Pvalue: 1.399

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04976337 1 215256745 KCNK2 4.02E-8 -0.013 1.13E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAST1 0.92 0.92
TRIM46 0.91 0.91
TNRC4 0.91 0.90
KIAA1543 0.91 0.91
DTX1 0.90 0.92
C7orf51 0.90 0.92
GNAZ 0.90 0.89
SPIRE2 0.90 0.92
BRF1 0.90 0.92
PIK3R2 0.90 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.72 -0.79
AF347015.27 -0.71 -0.79
MT-CO2 -0.70 -0.78
AF347015.33 -0.69 -0.76
AC021016.1 -0.68 -0.81
S100B -0.68 -0.76
COPZ2 -0.68 -0.75
AF347015.21 -0.67 -0.82
AF347015.8 -0.67 -0.77
MT-CYB -0.66 -0.74

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005244 voltage-gated ion channel activity IEA -
去：0005267 potassium channel activity IEA -
GO:0005216 离子通道活动 IEA -
GO:0015271 outward rectifier potassium channel activity NAS -
GO:0030955 potassium ion binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0007186 G蛋白偶联受体蛋白信号通路 IEA -
GO:0006811 ion transport IEA -
GO:0006813 potassium ion transport IEA -
GO:0006813 potassium ion transport NAS -
Cellular component GO term Evidence Neuro keywords PubMed ID
去：0016020 membrane IEA -
去：0016020 membrane NAS -
GO：0016021 integral to membrane IEA -
GO:0008076 voltage-gated potassium channel complex IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME NEURONAL SYSTEM 279 221 该途径中的所有SZGR 2.0基因
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS 12 7 该途径中的所有SZGR 2.0基因
REACTOME POTASSIUM CHANNELS 98 68 该途径中的所有SZGR 2.0基因
NEWMAN ERCC6 TARGETS DN 39 24 该途径中的所有SZGR 2.0基因
DELYS THYROID CANCER DN 232 154 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 该途径中的所有SZGR 2.0基因
BERENJENO通过RHOA转换 536 340 该途径中的所有SZGR 2.0基因
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 该途径中的所有SZGR 2.0基因
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN 25 18 该途径中的所有SZGR 2.0基因
MOHANKUMAR TLX1 TARGETS UP 414 287 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH PRC2 TARGETS 652 441 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 18HR DN 178 121 该途径中的所有SZGR 2.0基因
XU GH1 AUTOCRINE TARGETS DN 142 94 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 12HR DN 101 64 该途径中的所有SZGR 2.0基因
RIGGI EWING SARCOMA PROGENITOR DN 191 123 该途径中的所有SZGR 2.0基因
Acevedo肝癌，H3K27me3 UP 295 149 该途径中的所有SZGR 2.0基因
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 141 75 该途径中的所有SZGR 2.0基因
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 该途径中的所有SZGR 2.0基因
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 该途径中的所有SZGR 2.0基因
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA 77 52 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 491 319 该途径中的所有SZGR 2.0基因
WONG ADULT TISSUE STEM MODULE 721 492 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 68 50 该途径中的所有SZGR 2.0基因
国外RB1目标S GROWING 243 155 该途径中的所有SZGR 2.0基因
QI HYPOXIA 140 96 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE EARLY LATE 317 190 该途径中的所有SZGR 2.0基因
LE NEURONAL DIFFERENTIATION UP 18 13 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 474 480 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 473 480 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
mir-128 1904 1910 1A HSA-MIR-128A UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128B UCACAGUGAACCGGUCUCUUUC
miR-132/212 257 263 m8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-183 284 291 1A,m8 hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-19 1279 1286 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
miR-200bc/429 842 848 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-218 1345 1351 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-24 374 380 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-27 1904 1911 1A,m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-338 597 603 1A hsa-miR-338brain uccagauuuuuguuga