SZGR2 - Beplay体育中心

概括?

基因	379
象征	ARL4D
Synonyms	arf4l \| arl6
Description	ADP ribosylation factor like GTPase 4D
Reference	MIM:600732\|HGNC:HGNC:656\|Ensembl：ENSG00000175906\|HPRD:02842\|Vega:OTTHUMG00000180881
Gene type	protein-coding
Map location	17q21.31
Pascal p-value	0.081
Sherlock p-value	8.738E-4
度p-value	度:Maycox_2009:CC_BA10_fold_change=-1.18:CC_BA10_disease_P=0.0028:HBB_BA9_fold_change=-1.20:HBB_BA9_disease_P=0.0469
Fetal beta	0.122
DMG	1 (# studies)
eGene	Cerebellar Hemisphere Cerebellum Myers' cis & trans

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
度:Maycox_2009	Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissue	We included 51 genes whose expression changes are common between two schizophrenia cohorts.
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1

第一节遗传学和表观遗传学注释

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg19252218	17	41477271	ARL4D	3.901E-4	0.353	0.043	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16827037	chr3	117203284	ARL4D	379	0.04	trans
rs7029518	chr9	37782560	ARL4D	379	0.12	trans
rs17761129	chr15	24262387	ARL4D	379	0.15	trans
rs9319807	chr18	68766779	ARL4D	379	0.02	trans
RS16978981	chrX	13538144	ARL4D	379	0.07	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
KIAA1609	0.94	0.92
C20orf11	0.94	0.92
GTPBP1	0.94	0.92
TAF5L	0.94	0.92
CHMP7	0.93	0.94
NUP62	0.93	0.94
ZNF71	0.93	0.93
ZNF746	0.93	0.94
poldip3	0.93	0.92
GEMIN4	0.93	0.94

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.75	-0.89
AF347015.31	-0.75	-0.87
AF347015.27	-0.75	-0.87
C5orf53	-0.75	-0.78
AF347015.33	-0.74	-0.87
FXYD1	-0.74	-0.85
S100B	-0.74	-0.84
AF347015.8	-0.72	-0.87
MT-CYB	-0.72	-0.85
AC021016.1	-0.70	-0.83

第四节。蛋白质蛋白相互作用注释

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
ARL6IP1	AIP1 \| ARL6IP \| ARMER \| KIAA0069	ADP-ribosylation factor-like 6 interacting protein 1	-	HPRD	10508919
DNAJA1	DJ-2 \|DJA1 \|HDJ2 \|HSDJ \|HSJ2 \|HSPF4 \|HDJ-2	DNAJ（HSP40）同源物，亚家族A，成员1	两个杂交	BioGRID	16169070
EIF2B1	EIF-2B \| EIF-2Balpha \| EIF2B \| EIF2BA \| MGC117409 \| MGC125868 \| MGC125869	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	两个杂交	BioGRID	16169070
EML4	C2orf2 \| DKFZp686P18118 \| ELP120 \| FLJ10942 \| FLJ32318 \| ROPP120	echinoderm microtubule associated protein like 4	两个杂交	BioGRID	16169070
EPRS	DKFZp313B047 \| EARS \| GLUPRORS \| PARS \| PIG32 \| QARS \| QPRS	谷氨酰基 - 丙酰基-TRNA合成酶	两个杂交	BioGRID	16169070
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	两个杂交	BioGRID	16169070
NDRG1	CAP43 \| CMT4D \| DRG1 \| GC4 \| HMSNL \| NDR1 \| NMSL \| PROXY1 \| RIT42 \| RTP \| TARG1 \| TDD5	N-myc downstream regulated 1	两个杂交	BioGRID	16169070
PGAM1	PGAM-B \| PGAMA	phosphoglycerate mutase 1 (brain)	两个杂交	BioGRID	16169070
PRKCSH	AGE-R2 \| G19P1 \| PCLD \| PLD1	protein kinase C substrate 80K-H	两个杂交	BioGRID	16169070
SNRPN	DKFZp686C0927 \| DKFZp686M12165 \| DKFZp761I1912 \| DKFZp762N022 \| FLJ33569 \| FLJ36996 \| FLJ39265 \| HCERN3 \| MGC29886 \| PWCR \| RT-LI \| SM-D \| SMN \| SNRNP-N \| SNURF-SNRPN	small nuclear ribonucleoprotein polypeptide N	两个杂交	BioGRID	16169070
TLE1	ESG \| ESG1 \| GRG1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	两个杂交	BioGRID	16169070
UBR1	JBS \| MGC142065 \| MGC142067	泛素蛋白连接酶E3成分N-验证1	两个杂交	BioGRID	16169070
UNC119	HRG4	unc-119 homolog (C. elegans)	两个杂交	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
刘sox4靶向	137	94	该途径中的所有SZGR 2.0基因
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	该途径中的所有SZGR 2.0基因
Huttmann B Cll生存不佳	276	187	该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	该途径中的所有SZGR 2.0基因
WANG BARRETTS ESOPHAGUS AND ESOPHAGUS CANCER DN	37	22	该途径中的所有SZGR 2.0基因
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP	69	40	该途径中的所有SZGR 2.0基因
KOBAYASHI RESPONSE TO ROMIDEPSIN	19	14	该途径中的所有SZGR 2.0基因
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	该途径中的所有SZGR 2.0基因
BENPORATH SOX2 TARGETS	734	436	该途径中的所有SZGR 2.0基因
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP	62	38	该途径中的所有SZGR 2.0基因
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	该途径中的所有SZGR 2.0基因
LINDVALL IMMORTALIZED BY TERT DN	80	56	该途径中的所有SZGR 2.0基因
BURTON ADIPOGENESIS PEAK AT 8HR	39	31	该途径中的所有SZGR 2.0基因
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	该途径中的所有SZGR 2.0基因
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2	86	50	该途径中的所有SZGR 2.0基因
MARTENS TRETINOIN RESPONSE DN	841	431	该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP C	92	60	该途径中的所有SZGR 2.0基因
双龙血清敏感基因	90	54	该途径中的所有SZGR 2.0基因
BILANGES SERUM RESPONSE TRANSLATION	37	20	该途径中的所有SZGR 2.0基因
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP	271	165	该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	该途径中的所有SZGR 2.0基因

Gene Page:ARL4D