Gene Page:KIF5B

Summary?
GeneID 3799
Symbol KIF5B
Synonyms HEL-S-61|KINH|KNS|KNS1|UKHC
Description kinesin family member 5B
Reference MIM:602809|HGNC:HGNC:6324|Ensembl:ENSG00000170759|HPRD:07214|Vega:OTTHUMG00000017913
Gene type protein-coding
Map location 10p11.22
Pascal p-value 6.746E-4
Sherlock p-value 0.331
DEG p-value DEG:Sanders_2014:DS1_p=0.153:DS1_beta=0.013100:DS2_p=7.09e-01:DS2_beta=0.017:DS2_FDR=8.61e-01
Fetal beta 0.792
eGene Myers' cis & trans
Support INTRACELLULAR TRAFFICKING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DEG:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11008612 chr10 32016089 KIF5B 3799 0.1 cis
rs758167 chr12 1915558 KIF5B 3799 0 trans
rs2068673 chr12 60333402 KIF5B 3799 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003777 microtubule motor activity ISS -
GO:0005515 protein binding 新闻学会 17220478|17353931
GO:0005524 ATP binding IEA -
GO:0008017 microtubule binding ISS -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007028 cytoplasm organization IEA -
GO:0047496 vesicle transport along microtubule ISS -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0043005 neuron projection IEA neuron, axon, neurite, dendrite (GO term level: 5) -
去:0005871 kinesin complex TAS 1607388
GO:0005874 microtubule IEA -
GO:0005737 cytoplasm IEA -
GO:0048471 perinuclear region of cytoplasm ISS -
GO:0035253 ciliary rootlet IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
DTNB MGC17163 | MGC57126 dystrobrevin, beta Reconstituted Complex BioGRID 14600269
KIF5C FLJ44735 | KIAA0531 | KINN | MGC111478 | NKHC | NKHC-2 | NKHC2 kinesin family member 5C Affinity Capture-Western BioGRID 9624122
KLC1 KLC | KNS2 | KNS2A | MGC15245 kinesin light chain 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 9624122|10491391
|12475239
KLC2 FLJ12387 kinesin light chain 2 Affinity Capture-Western BioGRID 9624122|10491391
NME2 MGC111212 | NDPK-B | NDPKB | NM23-H2 | NM23B | puf non-metastatic cells 2, protein (NM23B) expressed in Affinity Capture-MS BioGRID 17353931
PLEKHM2 KIAA0842 | RP11-169K16.1 | SKIP pleckstrin homology domain containing, family M (with RUN domain) member 2 SKIP interacts with kinesin HC. BIND 15905402
SFN YWHAS stratifin Affinity Capture-MS BioGRID 15778465
SNAP23 HsT17016 | SNAP23A | SNAP23B synaptosomal-associated protein, 23kDa Reconstituted Complex
Two-hybrid		 BioGRID 12475239
SNAP25 FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2 synaptosomal-associated protein, 25kDa - HPRD,BioGRID 12475239
TRAK1 OIP106 trafficking protein, kinesin binding 1 OIP106 interacts with KIF5B. BIND 15644324
VDAC1 MGC111064 | PORIN | PORIN-31-HL voltage-dependent anion channel 1 Affinity Capture-MS BioGRID 17353931
YWHAB GW128 | HS1 | KCIP-1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Affinity Capture-MS BioGRID 17353931
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Affinity Capture-MS BioGRID 17353931
YWHAH YWHA1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Affinity Capture-MS
Far Western		 BioGRID 11969417
YWHAQ 14-3-3 | 1C5 | HS1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide Affinity Capture-MS BioGRID 17353931
YWHAZ KCIP-1 | MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID NCADHERIN PATHWAY 33 32 All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 91 61 All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
REACTOME INSULIN SYNTHESIS AND PROCESSING 21 15 All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132 101 All SZGR 2.0 genes in this pathway
REACTOME KINESINS 24 19 All SZGR 2.0 genes in this pathway
REACTOME止血 466 331 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP 119 66 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN 47 33 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN 52 34 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214 133 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2 54 39 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 40 31 All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN 58 43 All SZGR 2.0 genes in this pathway
布莱洛克ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 11 57 40 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 1 UP 35 25 All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 89 59 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 125 89 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING VIA ATM NOT VIA NFKB DN 38 23 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175 103 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 43 27 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 74 45 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182 102 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216 124 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 148 95 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-15/16/195/424/497 185 191 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-25/32/92/363/367 208 214 m8 hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-30-5p 243 249 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA