Gene Page:ARF5

Summary?
GeneID 381
Symbol ARF5
Synonyms -
Description ADP ribosylation factor 5
Reference MIM:103188|HGNC: HGNC: 658|Ensembl:ENSG00000004059|HPRD:00055|Vega:OTTHUMG00000023246
Gene type protein-coding
Map location 7q31.3
Pascal p-value 0.091
Sherlock p-value 0.826
Fetal beta -0.499
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14938677 7 127231698 ARF5 2.961E-4 0.34 0.039 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17795337 chr6 136492658 ARF5 381 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KARS 0.93 0.92
ACBD6 0.92 0.92
NIPSNAP1 0.92 0.94
IGBP1 0.91 0.92
CDK8 0.91 0.92
CCT3 0.91 0.93
RFWD2 0.91 0.94
PTDSS1 0.90 0.91
TEX10 0.90 0.93
CCT6A 0.90 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.72 -0.88
AF347015.33 -0.72 -0.89
MT-CO2 -0.71 -0.87
HLA-F -0.71 -0.82
AF347015.31 -0.70 -0.86
MT-CYB -0.70 -0.87
AF347015.8 -0.69 -0.88
HEPN1 -0.69 -0.81
AF347015.15 -0.68 -0.87
AIFM3 -0.68 -0.78

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID PI3KCI PATHWAY 49 40 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177 113 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN 25 13 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE DN 32 22 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION UP 86 55 All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR 37 22 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP 45 33 All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 92 68 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246 152 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
MUELLER COMMON TARGETS OF AML FUSIONS UP 14 10 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
金所有障碍少突细胞怒MBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway