SZGR2 - Beplay体育中心

Summary?

基因	3815
象征	成套工具
同义词	C-Kit\|CD117\|PBT\|SCFR
描述	成套工具proto-oncogene receptor tyrosine kinase
Reference	MIM:164920\|HGNC：HGNC：6342\|ENSEMBL：ENSG00000157404\|HPRD：01287\|Vega：Otthumg00000128713
基因type	protein-coding
地图位置	4q12
Pascal P值	0.193
Sherlock p-value	0.084
Fetal beta	0.797
eGene	Myers' cis & trans

基因in Data Sources

基因set name	基因组方法	描述	Info
CV:GWASdb	Genome-wide Association Studies	gwasdbrecords for schizophrenia
简历：PGCNP	全基因组协会研究	GWAS
PMID:cooccur	高通量文献搜索	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	点击to show details
网络	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0486

Section I. Genetics and epigenetics annotation

EQTL注释

SNP ID	Chromosome	Position	eGene	基因Entrez ID	PVALUE	qvalue	TSS distance	eQTL type
RS17199431	chr2	225810942	成套工具	3815		0.17		trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
IPO7	0.96	0.96
ube3a	0.95	0.95
CSNK1G3	0.95	0.95
CAND1	0.95	0.96
ATF2	0.95	0.96
ARMC1	0.95	0.95
Cul4b	0.95	0.95
ABCE1	0.94	0.94
FYTTD1	0.94	0.94
NUDT21	0.94	0.95

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
MT-CO2	-0.76	-0.81
AF347015.31	-0.75	-0.80
FXYD1	-0.74	-0.81
AF347015.8	-0.73	-0.80
MT-CYB	-0.73	-0.78
higd1b	-0.73	-0.79
AF347015.33	-0.73	-0.78
AF347015.21	-0.72	-0.80
AF347015.27	-0.72	-0.78
ifi27	-0.71	-0.78

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
去：0005021	vascular endothelial growth factor receptor activity	IEA		-
GO:0004872	受体活性	IEA		-
GO:0004716	receptor signaling protein tyrosine kinase activity	TAS		9438854
去：0005020	stem cell factor receptor activity	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		17662946
GO:0005524	ATP结合	IEA		-
GO:0016740	transferase activity	IEA		-
生物过程	GO term	Evidence	Neuro keywords	PubMed ID
去：0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA		-
去：0007243	protein kinase cascade	IEA		-
去：0007165	signal transduction	TAS		9990072
去：0008284	细胞增殖的阳性调节	IEA		-
GO：0048066	发育过程中的色素沉着	IEA		-
去：0009314	response to radiation	IEA		-
GO:0018108	peptidyl-tyrosine phosphorylation	IEA		-
GO：0019221	细胞因子介导的信号通路	IEA		-
GO:0043406	MAP激酶活性的阳性调节	IEA		-
去：0030097	血压	IEA		-
细胞分量	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	艾达		18029348
GO:0005737	cytoplasm	艾达		18029348
去：0016020	membrane	IEA		-
GO：0016021	integral to membrane	IEA		-
去：0009897	external side of plasma membrane	IEA		-
GO:0005886	质膜	艾达		18029348

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	断点群集区域	Affinity Capture-Western	BioGRID	8757502
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	Affinity Capture-Western	BioGRID	12177062
CD63	LAMP-3 \| ME491 \| MLA1 \| OMA81H \| TSPAN30	CD63分子	-	HPRD，Biogrid	12036870
CD81	S5.7 \|TAPA1 \|TSPAN28	CD81molecule	-	HPRD，Biogrid	12036870
CD9	5H9 \| BA2 \| BTCC-1 \| DRAP-27 \| GIG2 \| MIC3 \| MRP-1 \| P24 \| TSPAN29	CD9 molecule	-	HPRD，Biogrid	12036870
CLTC	CHC \| CHC17 \| CLH-17 \| CLTCL2 \| Hc \| KIAA0034	clathrin, heavy chain (Hc)	-	HPRD，Biogrid	10477727
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	-	HPRD，Biogrid	9092574
DOK1	MGC117395 \|MGC138860 \|p62dok	对接蛋白1，62KDA（酪氨酸激酶1的下游）	-	HPRD，Biogrid	11825908
EPOR	MGC138358	红细胞生成素受体	-	HPRD	11124255
抓钩	MGC64880	GRB2-related adaptor protein	-	HPRD，Biogrid	8647802
抓钩2	gads \|grap-2 \|grb2l \|grblg \|网格\|grpl \|grbx \|grf40 \|蒙娜\|p38	与GRB2相关的衔接蛋白2	-	HPRD	9872323
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	生长因子受体结合蛋白10	-	HPRD，Biogrid	11809791
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	生长因子受体结合蛋白2	Kit interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse proteins.	BIND	10022833
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	生长因子受体结合蛋白2	Grb2 interacts with c-Kit upon stimulation with SLF. This interaction was modeled on a demonstrated interaction between mouse Grb2 and human c-Kit.	BIND	7523381
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	生长因子受体结合蛋白2	-	HPRD，Biogrid	10377264
GRB7	-	生长因子受体结合蛋白7	-	HPRD，Biogrid	10377264
inpp5d	MGC104855 \|MGC142140 \|MGC142142 \|船\|Ship1 \|SIP-145 \|HP51CN	肌醇聚磷酸5-磷酸酶，145KDA	Reconstituted Complex	BioGRID	11071635
JAK2	JTK10	Janus激酶2（蛋白酪氨酸激酶）	-	HPRD，Biogrid	7527392\|8611693 \|9355737
Kitlg	DKFZp686F2250 \| KL-1 \| Kitl \| MGF \| SCF \| SF \| SHEP7	套件配体	-	HPRD	1375232 \| 7680037
Kitlg	DKFZp686F2250 \| KL-1 \| Kitl \| MGF \| SCF \| SF \| SHEP7	套件配体	Affinity Capture-Western Reconstituted Complex	BioGRID	1375232\|7680037
LCK	yt16 \|p56lck \|pp58lck	淋巴细胞特异性蛋白酪氨酸激酶	-	HPRD，Biogrid	9788619
LYN	FLJ26625 \|JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	c-Kit interacts with p53Lyn.	BIND	9341198
LYN	FLJ26625 \|JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD，Biogrid	9341198
LYN	FLJ26625 \|JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	C-kit与p56lyn相互作用。	BIND	9341198
matk	CHK \| CTK \| DKFZp434N1212 \| HHYLTK \| HYL \| HYLTK \| Lsk \| MGC1708 \| MGC2101	megakaryocyte-associated tyrosine kinase	-	HPRD，Biogrid	7536744\|9038210
MPDZ	DKFZP781P216 \|FLJ25909 \|FLJ34626 \|FLJ90240 \|mupp1	multiple PDZ domain protein	Reconstituted Complex Two-hybrid	BioGRID	11018522
PIK3R1	grb1 \|P85 \|p85-alpha	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Kit interacts with p85-alpha. This interaction was modeled on a demonstrated interaction between mouse proteins	BIND	10022833
PIK3R1	grb1 \|P85 \|p85-alpha	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD，Biogrid	7509796
PIK3R2	P85B \| p85 \| p85-BETA	磷酸肌醇3-激酶，调节亚基2（beta）	套件与p85-beta相互作用。这种相互作用是在小鼠蛋白之间证明的相互作用上建模的。	BIND	10022833
PIK3R2	P85B \| p85 \| p85-BETA	磷酸肌醇3-激酶，调节亚基2（beta）	Two-hybrid	BioGRID	10022833
PIK3R2	P85B \| p85 \| p85-BETA	磷酸肌醇3-激酶，调节亚基2（beta）	-	HPRD	7537096
PLCG1	PLC-II \|PLC1 \|PLC148 \|Plcgamma1	磷脂酶C，伽马1	Kit interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between mouse proteins.	BIND	10022833
PLCG1	PLC-II \|PLC1 \|PLC148 \|Plcgamma1	磷脂酶C，伽马1	-	HPRD，Biogrid	7536744
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD，Biogrid	7523381\|9528781
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	Syp interacts with c-Kit via its SH2 domain.	BIND	7523381
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	protein tyrosine phosphatase, non-receptor type 6	-	HPRD，Biogrid	7684496\|9528781
PTPRO	glepp1 \|PTP-U2 \|PTPU2	protein tyrosine phosphatase, receptor type, O	-	HPRD，Biogrid	10397721
RFC1	A1 \|MGC51786 \|MHCBFB \|po-ga \|recc1 \|RFC \|RFC140	replication factor C (activator 1) 1, 145kDa	Affinity Capture-Western	BioGRID	10353443
SH2B2	APS	SH2B adaptor protein 2	-	HPRD	10872802
SH3KBP1	CIN85 \| GIG10 \| MIG18	SH3核蛋白激酶结合蛋白1	Affinity Capture-Western	BioGRID	12177062
SOCS1	CIS1 \| CISH1 \|注射\| SOCS-1 \| SSI-1 \| SSI1 \|一句话	suppressor of cytokine signaling 1	-	HPRD，Biogrid	10022833
SOCS1	CIS1 \| CISH1 \|注射\| SOCS-1 \| SSI-1 \| SSI1 \|一句话	suppressor of cytokine signaling 1	Socs1 interacts with Kit. This interaction was modeled on a demonstrated interaction between mouse proteins	BIND	10022833
SPRED1	FLJ33903 \|NFL	发芽相关的EVH1域包含1个	-	HPRD	12646235
SPRED2	FLJ21897 \| FLJ31917 \| MGC163164 \| Spred-2	发芽相关的EVH1域，包含2个	-	HPRD	12646235\|14981116
Stap1	brdg1 \|Stap-1	信号转导适配器家族成员1	-	HPRD	10679268
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	STAT1-alpha interacts with c-kit	BIND	9355737
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD，Biogrid	9355737
TEC	MGC126760 \|MGC126762 \|PSCTK4	TEC蛋白酪氨酸激酶	-	HPRD，Biogrid	7526158
是的1	HsT441 \| P61-YES \| Yes \| c-yes	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	Reconstituted Complex	BioGRID	11071635

Section V. Pathway annotation

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG细胞因子细胞因子受体相互作用	267	161	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE	88	60	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
BIOCARTA坏途径	26	23	All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
PID套件途径	52	40	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
套件信号的反应组调节	17	10	All SZGR 2.0 genes in this pathway
刘前列腺癌DN	481	290	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN	198	110	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN	367	220	All SZGR 2.0 genes in this pathway
Smirnov在癌症中循环内皮细胞	158	103	All SZGR 2.0 genes in this pathway
Jaeger转移DN	258	141	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP	194	122	All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 16D的Takeda目标	175	108	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP	316	190	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
甲状腺癌DN	232	154	All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房3 4WK	214	144	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
ZIRN Tretinoin响应WT1 UP	23	14	All SZGR 2.0 genes in this pathway
Mahadevan伊马替尼抵抗DN	20	11	All SZGR 2.0 genes in this pathway
PAX3 FOXO1融合DN的Begum目标	45	34	All SZGR 2.0 genes in this pathway
Perez TP63目标	355	243	All SZGR 2.0 genes in this pathway
农民乳腺癌根源与腔内	326	213	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL	330	217	All SZGR 2.0 genes in this pathway
SHI SPARC TARGETS DN	13	8	All SZGR 2.0 genes in this pathway
Hatada甲基化在肺癌中	390	236	All SZGR 2.0 genes in this pathway
WEI mir34a目标	148	97	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时	487	286	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 DN	10	5	All SZGR 2.0 genes in this pathway
Hedvat Elf4靶向	12	8	All SZGR 2.0 genes in this pathway
PARK HSC MARKERS	44	31	All SZGR 2.0 genes in this pathway
中岛肥大细胞	46	34	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN	246	180	All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 4HR	54	36	All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn	1237	837	All SZGR 2.0 genes in this pathway
Browne HCMV感染24小时DN	148	102	All SZGR 2.0 genes in this pathway
Yamazaki TCEB3靶向	175	116	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C2	18	15	All SZGR 2.0 genes in this pathway
Nielsen Gist和滑膜肉瘤	20	15	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
LEIN CEREBELLUM MARKERS	85	47	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的BDN	564	326	All SZGR 2.0 genes in this pathway
Smid乳腺癌正常	476	285	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
MATZUK EMBRYONIC GERM CELL	19	16	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOGONIA	24	17	All SZGR 2.0 genes in this pathway
Qi Plasmacytoma Up	259	185	All SZGR 2.0 genes in this pathway
阿隆索转移神经	18	13	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN	209	137	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
Yagi AML带8 21易位	368	247	All SZGR 2.0 genes in this pathway
Korkola胚胎癌与精液瘤DN	25	14	All SZGR 2.0 genes in this pathway
黄成人组织茎模块	721	492	All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 UP	40	30	All SZGR 2.0 genes in this pathway
NIELSEN GIST	98	66	All SZGR 2.0 genes in this pathway
li诱导了自然杀手	307	182	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN	1972年	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP	61	41	All SZGR 2.0 genes in this pathway
Wang Thoc1靶向DN	20	14	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP	149	96	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
rao由SALL4同工型B绑定	517	302	All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL PROGENITOR UP	58	30	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	1649	1655	m8	HSA-MIR-130A^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				HSA-MIR-130b^brain	Cagugcaaugaagggauggau
				HSA-MIR-454-3P	uagugcaauauugcuuauaggguuu
miR-137	1963年	1969年	1a	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
mir-142-5p	2030	2036	m8	HSA-MIR-142-5P	CAUAAAGUAGAAAGCACUAC
miR-151	1241	1247	1a	hsa-miR-151^brain	ACUAGACUGAAGCUCCUUGAGG
mir-18	1672	1678	m8	hsa-miR-18a	uaagguggaugugcagaua
mir-18	1672	1678	m8	hsa-miR-18b	UAAGGUGCAUCUAGUGCAGUUA
mir-19	1648	1654	m8	hsa-miR-19a	ugugcaaauaugauaugaaaacuga
mir-19	1648	1654	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
mir-193	1088	1095	1a,m8	HSA-MIR-193A	AACUGGCCUACAAAGUCCCAG
mir-193	1088	1095	1a,m8	HSA-MIR-193B	AACUGGCCCUCAAAGUCCCGCUUU
miR-205	797	803	1a	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-218	844	850	m8	hsa-miR-218^brain	uugugcuugaucuaaccaugu
miR-221/222	1959年	1966年	1a,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1959年	1966年	1a,m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击hereto see the list of brain related miRNAs.

基因页：成套工具