Gene Page:KLC1

概括?
基因 3831
Symbol KLC1
Synonyms KLC|KNS2|KNS2A
Description kinesin light chain 1
Reference MIM:600025|HGNC：HGNC：6387|Ensembl:ENSG00000126214|HPRD:02489|Vega:OTTHUMG00000169227
Gene type protein-coding
Map location 14q32.3
Pascal p-value 3.161E-12
Sherlock p-value 0.982
Fetal beta -0.955
DMG 1 (# studies)
Support INTRACELLULAR TRAFFICKING
CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16317947 14 104151986 KLC1 5.844E-4 0.501 0.049 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CLDN3 0.74 0.31
KRT18P19 0.70 0.43
FOLR1 0.59 0.33
EGFL6 0.58 0.25
CCDC48 0.58 0.20
SLITRK6 0.57 0.25
MYH7 0.55 0.22
CD247 0.55 0.09
SLC5A5 0.54 0.14
FZD10 0.53 0.20
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC26A4 -0.20 -0.26
EPHB6 -0.20 -0.29
C1orf115 -0.19 -0.27
TRPV6 -0.19 -0.30
MCHR2 -0.18 -0.30
EPHX4 -0.18 -0.28
CIDEA -0.18 -0.22
ACTN2 -0.18 -0.26
ANKRD56 -0.18 -0.23
NPM2 -0.17 -0.30

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003777 microtubule motor activity IEA -
GO:0005515 protein binding IPI 11238452
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0008088 axon cargo transport IEA axon (GO term level: 8) -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0030424 axon IEA neuron, axon, Neurotransmitter (GO term level: 6) -
GO:0005829 cytosol ISS -
GO:0005871 kinesin complex ISS -
GO:0005874 microtubule IEA -
GO:0005737 cytoplasm IEA -
GO:0035253 ciliary rootlet IEA -
GO:0031410 cytoplasmic vesicle IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID ARF6 TRAFFICKING PATHWAY 49 34 All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 91 61 All SZGR 2.0 genes in this pathway
巨核细胞发育和血小板产生涉及的反应组因素 132 101 All SZGR 2.0 genes in this pathway
REACTOME KINESINS 24 19 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
FRASOR TAMOXIFEN RESPONSE UP 51 36 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP 112 68 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR DN 88 53 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214 134 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 8Q24 DN 46 28 All SZGR 2.0 genes in this pathway
Wang通过MAPK8向上对紫杉醇的响应 14 9 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214 139 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382 224 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN 110 64 All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞和大脑问TL CIS 65 38 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205 126 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP 63 48 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 83 66 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
KANG FLUOROURACIL RESISTANCE UP 22 15 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 139 95 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP 67 48 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-221/222 212 218 m8 HSA-MIR-221brain AGCUACAUUGUCUGCUGGGUUUC
HSA-MIR-222brain AGCUACAUCUGGCUACUGGGUCUC