Gene Page:IPO5

Summary?
GeneID 3843
Symbol IPO5
同义词 IMB3|KPNB3|Pse1|RANBP5|imp5
Description importin 5
Reference MIM:602008|HGNC:HGNC:6402|Ensembl:ENSG00000065150|HPRD:03597|Vega:OTTHUMG00000017244
Gene type protein-coding
Map location 13q32.2
Pascal p-value 0.939
Sherlock p-value 0.005
Fetal beta 0.421
DMG 1 (# studies)
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed的genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 2 Link to SZGene
Expression Meta-analysis of gene expression Pvalue: 1.509
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.2023

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05126147 13 98628060 IPO5 3.42E-10 -0.008 7.22E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005095 GTPase inhibitor activity TAS 9271386
GO:0005488 binding IEA -
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 15282309
GO:0008536 Ran GTPase binding TAS 9114010
GO:0008565 protein transporter activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000059 protein import into nucleus, docking IEA -
GO:0006607 NLS-bearing substrate import into nucleus TAS 9114010
GO:0006886 intracellular protein transport IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 9114010
GO:0005643 nuclear pore TAS 9271386
GO:0005737 cytoplasm TAS 9114010

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
H1F0 H10 | H1FV | MGC5241 H1 histone family, member 0 in vitro BioGRID 10228156
NUP153 HNUP153 | N153 nucleoporin 153kDa - HPRD, BioGRID 9114010
NUP214 CAIN | CAN | D9S46E | MGC104525 | N214 nucleoporin 214kDa - HPRD, BioGRID 9114010
NUP98 ADIR2 | NUP196 | NUP96 nucleoporin 98kDa - HPRD 9114010
RAG2 RAG-2 recombination activating gene 2 - HPRD 12861017
RAN ARA24 | Gsp1 | TC4 RAN, member RAS oncogene family - HPRD, BioGRID 9114010
RANBP2 NUP358 | TRP1 | TRP2 RAN binding protein 2 - HPRD 9114010
RPL23A FLJ27455 | MDA20 ribosomal protein L23a Affinity Capture-Western
in vitro		 BioGRID 9687515|11682607
RPL5 MGC117339 | MSTP030 ribosomal protein L5 - HPRD, BioGRID 9687515
RPS7 - ribosomal protein S7 - HPRD, BioGRID 9687515
SRP19 - signal recognition particle 19kDa Affinity Capture-Western
Reconstituted Complex		 BioGRID 11682607


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME INFLUENZA LIFE CYCLE 203 72 All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 169 47 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194 112 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP 121 71 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS 41 26 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM 32 15 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR 43 30 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
王肿瘤INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163 102 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
IRITANI MAD1 TARGETS DN 47 30 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 143 86 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 4 10 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
mir - 181 588 594 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-186 1248 1254 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-23 590 597 1A,m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-323 590 596 1A hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-377 1059 1066 1A,m8 hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-505 1145 1151 1A hsa-miR-505 GUCAACACUUGCUGGUUUCCUC