基因页：KRAS

年代ummary?
基因 3845
象征 KRAS
同义词 c-k-ras | cfc2 | k-ras2a | k-ras2b | k-ras4a | k-ras4b | ki-ras | kras1 | kras2 | kras2 | ns | ns3 | rald | rald | rask2
Description Kirsten大鼠肉瘤病毒癌基因同源物
Reference MIM:190070|HGNC：HGNC：6407|Ensembl:ENSG00000133703|HPRD:01817|Vega：Otthumg00000171193
Gene type protein-coding
地图位置 12p12.1
Pascal P值 0.937
年代herlock p-value 0.306
Fetal beta 0.194
DMG 1 (# studies)
eGene 元
支持 CANABINOID
DOPAMINE
细胞内信号转导
METABOTROPIC GLUTAMATE RECEPTOR
5-羟色胺
G2CDB.HUMANPSP
CompositeSet

Gene in Data Sources
Gene set name 基因组方法 Description Info
简历：PGCNP 全基因组协会研究 GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
PMID:cooccur High-throughput literature-search 年代ystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击to show details
go_annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：3
网络 年代hortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0024

年代ection I. Genetics and epigenetics annotation

@差异甲基化基因

探测 Chromosome Position 最近的基因 P (dis) Beta (dis) FDR (dis) 年代tudy
CG02850821 12 25403680 KRAS -0.024 0.68 DMG:Nishioka_2013


年代ection II. Transcriptome annotation

General gene expression (GTEx)

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


年代ection III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
去：0003924 GTPase activity IEA -
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 11857081|12732644
GO:0005525 GTP结合 IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0048169 regulation of long-term neuronal synaptic plasticity IEA neuron, Synap (GO term level: 10) -
GO：0032228 调节突触传播，GABA能量 IEA 神经元，GABA，突触，神经递质（GO术语级别：9） -
GO:0043524 negative regulation of neuron apoptosis IEA neuron (GO term level: 9) -
去：0007265 Ras protein signal transduction 经验 11520933
去：0007265 Ras protein signal transduction IEA -
GO:0008284 细胞增殖的阳性调节 IEA -
GO:0008542 visual learning IEA -
GO:0007605 声音的感官感知 IEA -
去：0007569 细胞衰老 IEA -
GO:0006897 endocytosis IEA -
去：0030036 肌动蛋白细胞骨架组织 IEA -
GO:0035022 positive regulation of Rac protein signal transduction IEA -
GO:0051146 striated muscle cell differentiation IEA -
蜂窝组件 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005624 膜分数 IEA -
GO:0005886 质膜 经验 7972015|8493579|9069260
|9690470
GO:0005886 质膜 IEA -

年代ection IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental 年代ource PubMed ID
BCL2 Bcl-2 B-cell CLL/lymphoma 2 - HPRD 10490827
EPB42 MGC116735 | MGC116737 | PA erythrocyte membrane protein band 4.2 Reconstituted Complex BioGRID 3276554
HNRNPC C1 |C2 |hnrnp |HNRPC |MGC104306 |MGC105117 |MGC117353 |MGC131677 |SNRPC 异质性核核糖核蛋白C（C1/C2） Two-hybrid BioGRID 16189514
HSPD1 CPN60 |凹槽|HSP60 |HSP65 |hucha60 |SPG13 heat shock 60kDa protein 1 (chaperonin) 体内 BioGRID 11888933
PIK3CA MGC142161 |MGC142163 |PI3K |p110-alpha phosphoinositide-3-kinase, catalytic, alpha polypeptide Two-hybrid BioGRID 10783161
PIK3CG pi3cg |PI3K |pi3kgamma |PIK3 phosphoinositide-3-kinase, catalytic, gamma polypeptide - HPRD，Biogrid 10542052
RAF1 CRAF | NS5 | Raf-1 | c-Raf V-RAF-1鼠白血病病毒癌基因同源1 Affinity Capture-Western
Two-hybrid		 BioGRID 10783161|10882715
ralgds FLJ20922 | RGF | RalGEF ral guanine nucleotide dissociation stimulator Reconstituted Complex
Two-hybrid		 BioGRID 7809086|10783161
RAP1GDS1 GDS1 | MGC118859 | MGC118861 | SmgGDS RAP1, GTP-GDP dissociation stimulator 1 - HPRD，Biogrid 11948427
RASGRP2 CALDAG-GEFI | CDC25L RAS guanyl releasing protein 2 (calcium and DAG-regulated) - HPRD 10918068
RASSF2 DKFZp781O1747 | KIAA0168 | RASFADIN RAS协会（RALGDS/AF-6）域家庭成员2 - HPRD，Biogrid 12732644
RASSF5 MGC10823 | MGC17344 | Maxp1 | NORE1 | NORE1A | NORE1B | RAPL | RASSF3 RAS协会（RALGDS/AF-6）域家庭成员5 - HPRD，Biogrid 11857081
Shoc2 FLJ60412 | KIAA0862 | SIAA0862 | SOC-2 | SOC2 | SUR-8 | SUR8 SOC-2清晰同源物的抑制器（秀丽隐杆线虫） - HPRD，Biogrid 9674433|10783161


年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
kegg dorso腹轴形成 25 21 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 134 86 All SZGR 2.0 genes in this pathway
kegg间隙交界处 90 68 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
kegg t细胞受体信号通路 108 89 All SZGR 2.0 genes in this pathway
KEGG B细胞受体信号通路 75 56 All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 79 58 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG神经营养蛋白信号传导途径 126 103 All SZGR 2.0 genes in this pathway
KEGG长期抑郁症 70 53 All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG孕酮介导的卵母细胞成熟 86 59 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 42 29 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 62 47 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 70 56 All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 52 45 All SZGR 2.0 genes in this pathway
Kegg神经胶质瘤 65 56 All SZGR 2.0 genes in this pathway
KEGG前列腺癌 89 75 All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER 29 26 All SZGR 2.0 genes in this pathway
Kegg黑色素瘤 71 57 All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER 42 33 All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 73 59 All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA 60 47 All SZGR 2.0 genes in this pathway
KEGG非小细胞肺癌 54 47 All SZGR 2.0 genes in this pathway
Biocarta Tel Pathway 18 15 All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY 37 31 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID ER非原始组途径 41 35 All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 40 38 All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 53 42 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 55 43 All SZGR 2.0 genes in this pathway
PID ERBB1受体近端途径 35 29 All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY 14 14 All SZGR 2.0 genes in this pathway
PID PI3KCI途径 49 40 All SZGR 2.0 genes in this pathway
PID ERBB1下游途径 105 78 All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3途径 44 35 All SZGR 2.0 genes in this pathway
PID PDGFRB途径 129 103 All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 62 48 All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 84 61 All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY 41 35 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 34 All SZGR 2.0 genes in this pathway
PID RAS路径 30 22 All SZGR 2.0 genes in this pathway
PID MAPK TRK途径 34 31 All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY 36 31 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
NGF的Reactome信号传导 217 167 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 78 59 All SZGR 2.0 genes in this pathway
Reactome发育生物学 396 292 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 90 67 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
组成性活性EGFR的反应组信号传导 18 13 All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome GRB2事件 22 20 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING 20 17 All SZGR 2.0 genes in this pathway
B细胞受体BCR的Reactome下游信号传导事件 97 66 All SZGR 2.0 genes in this pathway
B细胞受体BCR的反应组信号传导 126 90 All SZGR 2.0 genes in this pathway
Reactome胰岛素受体信号传导级联 87 64 All SZGR 2.0 genes in this pathway
Reactome Arms介导的激活 17 17 All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS 19 18 All SZGR 2.0 genes in this pathway
Reactome对RAS的信号传导 27 23 All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 91 65 All SZGR 2.0 genes in this pathway
Reactome NGF信号通过TRKA从质膜发出 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 36 30 All SZGR 2.0 genes in this pathway
REACTOME P38MAPK EVENTS 13 12 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 15 14 All SZGR 2.0 genes in this pathway
Reactome胃胃CREB信号传导途径通过PKC和MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS 44 29 All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING 15 13 All SZGR 2.0 genes in this pathway
Reactome Tie2信号传导 17 13 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导 122 93 All SZGR 2.0 genes in this pathway
Reactome下游信号转导 95 76 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH 64 49 All SZGR 2.0 genes in this pathway
Reactome FRS2介导的级联 36 27 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
Reactome SHC介导的级联 28 19 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
Reactome IL 2信号传导 41 34 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
Reactome SOS介导的信号传导 14 13 All SZGR 2.0 genes in this pathway
反应组止血 466 331 All SZGR 2.0 genes in this pathway
Reactome RAF MAP激酶级联 10 10 All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING 15 12 All SZGR 2.0 genes in this pathway
Reactome免疫系统 933 616 All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
Reactome SHC相关事件 17 13 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央 285 181 All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONAL CARCINOMA UP 41 27 All SZGR 2.0 genes in this pathway
年代ENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
Odonnell TFRC靶向 456 228 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡 1781 1082 All SZGR 2.0 genes in this pathway
TAKADA GASTRIC CANCER COPY NUMBER UP 7 5 All SZGR 2.0 genes in this pathway
Yanagihara ESX1目标 30 19 All SZGR 2.0 genes in this pathway
曼回应AMIFOSTINE DN 10 5 All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌DN 203 134 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发6小时DN 514 330 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
丁肺癌显着突变 26 22 All SZGR 2.0 genes in this pathway
年代WEET KRAS TARGETS DN 66 39 All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169 112 All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR 37 22 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
ABE VEGFA TARGETS 30MIN 29 21 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER UP 73 53 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向 601 369 All SZGR 2.0 genes in this pathway
Labbe TGFB1靶向 102 64 All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 111 69 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C簇 38 26 All SZGR 2.0 genes in this pathway
甜肺癌克拉斯 491 316 All SZGR 2.0 genes in this pathway
Bruneau分隔室 10 8 All SZGR 2.0 genes in this pathway
年代HAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 101 76 All SZGR 2.0 genes in this pathway
年代HAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE 67 51 All SZGR 2.0 genes in this pathway
年代HAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE 81 66 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
丁肺癌反复突变 6 5 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 103 68 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 148 95 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972年 1213 All SZGR 2.0 genes in this pathway
ikeda mir30目标 116 87 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 3352 3358 1a HSA-MIR-124A UUAAGGCACGCGGUGAAUGCCA
miR-134 3506 3512 1a hsa-miR-134brain UGUGACUGGUUGACCAGAGGG
miR-143 1599 1606年 1a,m8 hsa-miR-143brain ugagaugaagcacuguagcuca
hsa-miR-143brain ugagaugaagcacuguagcuca
miR-155 84 90 m8 hsa-miR-155 uuaaugcuaaucgugauagggg
mir-19 3567 3573 1a hsa-miR-19a ugugcaaauaugauaugaaaacuga
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
mir-190 4378 4384 1a hsa-miR-190 ugauuauguuugauauauauaggu
mir-193 182 188 1a HSA-MIR-193A AACUGGCCUACAAAGUCCCAG
HSA-MIR-193B AACUGGCCCUCAAAGUCCCGCUUU
mir-199 1497 1503 1a hsa-miR-199a cccaguucagacuaccuguuc
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429 184 190 m8 hsa-miR-200b uaauacugccugguaaugaugac
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-216 1245 1251 m8 hsa-miR-216 UAAUCUCAGCUGGCAACUGUG
miR-217 4320 4326 m8 hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
mir-27 4447 4453 1a hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain uucacaguggcuaaguucugc
miR-30-3p 4273 4279 m8 hsa-miR-30a-3p cuuucagucggauguugcagc
hsa-miR-30e-3p cuuucagucggauguauacagc
miR-30-5p 4231 4237 m8 HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-346 716 722 m8 hsa-miR-346brain ugucugccccgcaugccugccucu
miR-381 4260 4266 1a hsa-miR-381 uauacaagggcaagcucucugu
miR-433-3p 4480 4486 1a hsa-miR-433brain aucaugauggggcuccucggugu
miR-448 4318 4324 m8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-505 4162 4168 1a HSA-MIR-505 GUCAACACUUGCUGGUUUCCUC
HSA-MIR-505 GUCAACACUUGCUGGUUUCCUC
miR-543 4368 4374 m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU
mir-96 4193 4199 m8 HSA-MIR-96brain UUUGGCACUAGCACAUUUUUGC