Gene Page:KRT15

Summary?
GeneID 3866
Symbol KRT15
Synonyms CK15|K15|K1CO
Description keratin 15
Reference MIM:148030|HGNC:HGNC:6421|HPRD:01009|
Gene type protein-coding
Map location 17q21.2
帕斯卡假定值 0.405
TADA p-value 0.011
Fetal beta -0.041
eGene Myers' cis & trans
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
KRT15 chr17 39673416 A T NM_002275
NM_002275		 .
p.167I>N		 splice
missense		 Schizophrenia DNM:Fromer_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17799628 chr9 106442995 KRT15 3866 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ABI2 ABI-2 | ABI2B | AIP-1 | AblBP3 | SSH3BP2 | argBPIA | argBPIB abl interactor 2 Two-hybrid BioGRID 16189514
ABI3 NESH | SSH3BP3 ABI family, member 3 Two-hybrid BioGRID 16189514
ABLIM1 ABLIM | DKFZp781D0148 | FLJ14564 | KIAA0059 | LIMAB1 | LIMATIN | MGC1224 actin binding LIM protein 1 Two-hybrid BioGRID 16189514
AMOTL2 LCCP angiomotin像2 Two-hybrid BioGRID 16189514
ANKRD26L1 MGC12538 ankyrin repeat domain 26-like 1 Two-hybrid BioGRID 16189514
ARC Arg3.1 | KIAA0278 activity-regulated cytoskeleton-associated protein Two-hybrid BioGRID 16189514
C10orf10 DEPP | FIG chromosome 10 open reading frame 10 Two-hybrid BioGRID 16189514
C1orf216 FLJ38984 chromosome 1 open reading frame 216 Two-hybrid BioGRID 16189514
C1orf65 FLJ35728 | RP11-76K24.1 chromosome 1 open reading frame 65 Two-hybrid BioGRID 16189514
CALCOCO1 Cocoa | KIAA1536 | PP13275 | calphoglin calcium binding and coiled-coil domain 1 Two-hybrid BioGRID 16189514
CCDC101 FLJ32446 coiled-coil domain containing 101 Two-hybrid BioGRID 16189514
CCDC120 JM11 coiled-coil domain containing 120 Two-hybrid BioGRID 16189514
DGCR6L FLJ10666 DiGeorge syndrome critical region gene 6-like Two-hybrid BioGRID 16189514
EXOC8 EXO84 | Exo84p | SEC84 exocyst complex component 8 Two-hybrid BioGRID 16189514
FAM107A DRR1 | FLJ30158 | FLJ45473 | TU3A family with sequence similarity 107, member A Two-hybrid BioGRID 16189514
FAM164C C14orf140 | FLJ23093 family with sequence similarity 164, member C Two-hybrid BioGRID 16189514
HOXB6 HOX2 | HOX2B | HU-2 | Hox-2.2 homeobox B6 Two-hybrid BioGRID 16189514
KIAA0408 FLJ43995 | RP3-403A15.2 KIAA0408 Two-hybrid BioGRID 16189514
KIAA1217 DKFZp761L0424 | MGC31990 | SKT KIAA1217 Two-hybrid BioGRID 16189514
KIAA1267 DKFZp686P06109 | DKFZp727C091 | MGC102843 KIAA1267 Two-hybrid BioGRID 16189514
KRT18 CYK18 | K18 keratin 18 Two-hybrid BioGRID 16189514
KRT19 CK19 | K19 | K1CS | MGC15366 keratin 19 Two-hybrid BioGRID 16189514
KRT20 CD20 | CK20 | K20 | KRT21 | MGC35423 keratin 20 Two-hybrid BioGRID 16189514
KRT6A CK6A | CK6C | CK6D | K6A | K6C | K6D | KRT6C | KRT6D keratin 6A Two-hybrid BioGRID 16189514
KRT6B CK6B | K6B | KRTL1 | PC2 keratin 6B Two-hybrid BioGRID 16189514
KRT81 HB1 | Hb-1 | KRTHB1 | MLN137 | ghHkb1 | hHAKB2-1 keratin 81 Two-hybrid BioGRID 16189514
LDOC1 BCUR1 | Mar7 | Mart7 leucine zipper, down-regulated in cancer 1 Two-hybrid BioGRID 16189514
LNX1 LNX | MPDZ | PDZRN2 ligand of numb-protein X 1 Two-hybrid BioGRID 16189514
MAD2L1BP CMT2 | KIAA0110 | MGC11282 | RP1-261G23.6 MAD2L1 binding protein Two-hybrid BioGRID 16189514
MCM10 CNA43 | DNA43 | MGC126776 | PRO2249 minichromosome maintenance complex component 10 Two-hybrid BioGRID 16189514
NIF3L1 ALS2CR1 | CALS-7 | MDS015 NIF3 NGG1 interacting factor 3-like 1 (S. pombe) Two-hybrid BioGRID 16189514
NOC4L MGC3162 | NOC4 nucleolar complex associated 4 homolog (S. cerevisiae) Two-hybrid BioGRID 16189514
NUDT18 FLJ22494 nudix (nucleoside diphosphate linked moiety X)-type motif 18 Two-hybrid BioGRID 16189514
PCM1 PTC4 pericentriolar material 1 Two-hybrid BioGRID 16189514
PRPH NEF4 | PRPH1 peripherin Two-hybrid BioGRID 16189514
PSMA1 HC2 | MGC14542 | MGC14575 | MGC14751 | MGC1667 | MGC21459 | MGC22853 | MGC23915 | NU | PROS30 山龙眼some (prosome, macropain) subunit, alpha type, 1 Two-hybrid BioGRID 16189514
PSMC5 S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUG 山龙眼some (prosome, macropain) 26S subunit, ATPase, 5 Two-hybrid BioGRID 16189514
RCOR3 FLJ10876 | FLJ16298 | RP11-318L16.1 REST corepressor 3 Affinity Capture-Western
Two-hybrid		 BioGRID 16189514
RHPN1 KIAA1929 | ODF5 | RHOPHILIN | RHPN rhophilin, Rho GTPase binding protein 1 Two-hybrid BioGRID 16189514
RIBC2 C22orf11 RIB43A domain with coiled-coils 2 Two-hybrid BioGRID 16189514
SMARCD1 BAF60A | CRACD1 | Rsc6p SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Two-hybrid BioGRID 16189514
TCHP MGC10854 trichoplein, keratin filament binding Two-hybrid BioGRID 16189514
TEKT4 MGC27019 tektin 4 Two-hybrid BioGRID 16189514
TSG101 TSG10 | VPS23 tumor susceptibility gene 101 Two-hybrid BioGRID 16189514
TUBGCP4 76P | FLJ14797 | GCP4 tubulin, gamma complex associated protein 4 Two-hybrid BioGRID 16189514
TXNDC11 EFP1 thioredoxin domain containing 11 Two-hybrid BioGRID 16189514
USHBP1 AIEBP | FLJ38709 | FLJ90681 | MCC2 开创症侯群e 1C binding protein 1 Two-hybrid BioGRID 16189514
USP2 UBP41 | USP9 ubiquitin specific peptidase 2 Affinity Capture-Western
Two-hybrid		 BioGRID 16189514
WAC BM-016 | MGC10753 | PRO1741 | Wwp4 | bA48B24 | bA48B24.1 WW domain containing adaptor with coiled-coil Two-hybrid BioGRID 16189514
ZNF638 DKFZp686P1231 | MGC26130 | MGC90196 | NP220 | ZFML | Zfp638 zinc finger protein 638 Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198 110 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN 91 53 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP 121 45 All SZGR 2.0 genes in this pathway
ROY WOUND BLOOD VESSEL DN 22 14 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232 139 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171 112 All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS DN 91 58 All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS DN 104 72 All SZGR 2.0 genes in this pathway
LIU CDX2 TARGETS DN 8 5 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230 115 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN 59 32 All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE UP 79 58 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 56 35 All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER UP 92 45 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL DN 59 44 All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS DN 51 29 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306 191 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C5 10 7 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway