Gene Page:KRT81
Summary?
| GeneID | 3887 |
| Symbol | KRT81 |
| Synonyms | HB1|Hb-1|KRTHB1|MLN137|ghHkb1|hHAKB2-1 |
| Description | keratin 81 |
| Reference | MIM:602153|HGNC:HGNC:6458|Ensembl:ENSG00000205426|HPRD:03691|Vega:OTTHUMG00000167574 |
| Gene type | protein-coding |
| Map location | 12q13 |
| Pascal p-value | 0.032 |
| eGene | Anterior cingulate cortex BA24 Cortex Frontal Cortex BA9 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12832364 | 12 | 52699213 | KRT81 | ENSG00000205426.6 | 8.935E-7 | 0.02 | -13895 | gtex_brain_ba24 |
| rs1137013 | 12 | 52702633 | KRT81 | ENSG00000205426.6 | 1.147E-6 | 0.02 | -17315 | gtex_brain_ba24 |
| rs2857673 | 12 | 52707973 | KRT81 | ENSG00000205426.6 | 1.855E-6 | 0.02 | -22655 | gtex_brain_ba24 |
| rs11285858 | 12 | 52708090 | KRT81 | ENSG00000205426.6 | 1.858E-6 | 0.02 | -22772 | gtex_brain_ba24 |
| rs2852469 | 12 | 52709429 | KRT81 | ENSG00000205426.6 | 1.872E-6 | 0.02 | -24111 | gtex_brain_ba24 |
| rs2852468 | 12 | 52709880 | KRT81 | ENSG00000205426.6 | 1.876E-6 | 0.02 | -24562 | gtex_brain_ba24 |
| rs2248473 | 12 | 52709883 | KRT81 | ENSG00000205426.6 | 1.876E-6 | 0.02 | -24565 | gtex_brain_ba24 |
| rs11611330 | 12 | 52710037 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -24719 | gtex_brain_ba24 |
| rs56118466 | 12 | 52710102 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -24784 | gtex_brain_ba24 |
| rs55722266 | 12 | 52710198 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -24880年 | gtex_brain_ba24 |
| rs2270267 | 12 | 52710246 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -24928 | gtex_brain_ba24 |
| rs2257286 | 12 | 52710309 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -24991 | gtex_brain_ba24 |
| rs2857669 | 12 | 52710715 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -25397 | gtex_brain_ba24 |
| rs2852463 | 12 | 52710897 | KRT81 | ENSG00000205426.6 | 1.878E-6 | 0.02 | -25579 | gtex_brain_ba24 |
| rs2857668 | 12 | 52710898 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -25580 | gtex_brain_ba24 |
| rs2852462 | 12 | 52710913 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -25595 | gtex_brain_ba24 |
| rs2852460 | 12 | 52711416 | KRT81 | ENSG00000205426.6 | 1.877E-6 | 0.02 | -26098 | gtex_brain_ba24 |
| rs2857667 | 12 | 52711549 | KRT81 | ENSG00000205426.6 | 2.46E-6 | 0.02 | -26231 | gtex_brain_ba24 |
| rs2857666 | 12 | 52711624 | KRT81 | ENSG00000205426.6 | 1.858E-6 | 0.02 | -26306 | gtex_brain_ba24 |
| rs2852459 | 12 | 52711776 | KRT81 | ENSG00000205426.6 | 1.843E-6 | 0.02 | -26458 | gtex_brain_ba24 |
| rs2852458 | 12 | 52712249 | KRT81 | ENSG00000205426.6 | 1.794E-6 | 0.02 | -26931 | gtex_brain_ba24 |
| rs998820 | 12 | 52712746 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -27428 | gtex_brain_ba24 |
| rs998821 | 12 | 52712813 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -27495 | gtex_brain_ba24 |
| rs2187512 | 12 | 52712898 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -27580 | gtex_brain_ba24 |
| rs2857662 | 12 | 52713417 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -28099 | gtex_brain_ba24 |
| rs4237897 | 12 | 52713697 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -28379 | gtex_brain_ba24 |
| rs4237898 | 12 | 52713781 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -28463 | gtex_brain_ba24 |
| rs2852467 | 12 | 52713803 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -28485 | gtex_brain_ba24 |
| rs2852466 | 12 | 52714097 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -28779 | gtex_brain_ba24 |
| rs2852465 | 12 | 52714138 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -28820 | gtex_brain_ba24 |
| rs1540095 | 12 | 52715363 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -30045 | gtex_brain_ba24 |
| rs1540093 | 12 | 52715876 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -30558 | gtex_brain_ba24 |
| rs17656443 | 12 | 52716522 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -31204 | gtex_brain_ba24 |
| rs9919675 | 12 | 52717622 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -32304 | gtex_brain_ba24 |
| rs7133284 | 12 | 52717686 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -32368 | gtex_brain_ba24 |
| rs1573514 | 12 | 52719253 | KRT81 | ENSG00000205426.6 | 2.945E-6 | 0.02 | -33935 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FBN1 | 0.77 | 0.73 |
| EIF4G1 | 0.76 | 0.83 |
| MYH10 | 0.75 | 0.81 |
| TMEM131 | 0.75 | 0.83 |
| LARP4B | 0.74 | 0.78 |
| FHOD3 | 0.74 | 0.82 |
| SEC23IP | 0.73 | 0.78 |
| DNAJC13 | 0.73 | 0.81 |
| HGSNAT | 0.73 | 0.80 |
| DYNC1H1 | 0.73 | 0.76 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.65 | -0.71 |
| AF347015.33 | -0.64 | -0.68 |
| MT-CO2 | -0.64 | -0.71 |
| AF347015.27 | -0.63 | -0.69 |
| AF347015.8 | -0.63 | -0.69 |
| AF347015.2 | -0.63 | -0.69 |
| MT-CYB | -0.62 | -0.66 |
| HIGD1B | -0.62 | -0.69 |
| FXYD1 | -0.62 | -0.65 |
| AF347015.21 | -0.61 | -0.70 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENESE HDAC1 AND HDAC2 TARGETS DN | 232 | 139 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC2 TARGETS DN | 133 | 77 | All SZGR 2.0 genes in this pathway |
| PROVENZANI METASTASIS DN | 136 | 94 | All SZGR 2.0 genes in this pathway |
| PACHER TARGETS OF IGF1 AND IGF2 UP | 35 | 27 | All SZGR 2.0 genes in this pathway |
| MUELLER METHYLATED IN GLIOBLASTOMA | 40 | 22 | All SZGR 2.0 genes in this pathway |
| LIN SILENCED BY TUMOR MICROENVIRONMENT | 108 | 73 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS | 185 | 114 | All SZGR 2.0 genes in this pathway |
| FRASOR RESPONSE TO ESTRADIOL DN | 82 | 52 | All SZGR 2.0 genes in this pathway |
| LEI MYB TARGETS | 318 | 215 | All SZGR 2.0 genes in this pathway |
| YEGNASUBRAMANIAN PROSTATE CANCER | 128 | 60 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE UP | 578 | 341 | All SZGR 2.0 genes in this pathway |
| HUANG FOXA2 TARGETS DN | 36 | 21 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE DN | 315 | 197 | All SZGR 2.0 genes in this pathway |
| 乳腺癌萧述三腔的DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
| HUPER BREAST BASAL VS LUMINAL DN | 59 | 44 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| TAVAZOIE METASTASIS | 108 | 68 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 1 UP | 125 | 61 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 2 UP | 54 | 31 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 5 UP | 12 | 8 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 7 UP | 118 | 68 | All SZGR 2.0 genes in this pathway |
| PEDERSEN METASTASIS BY ERBB2 ISOFORM 1 | 46 | 33 | All SZGR 2.0 genes in this pathway |
| ZWANG EGF INTERVAL UP | 105 | 46 | All SZGR 2.0 genes in this pathway |