Gene Page:ARHGAP1

Summary?
GeneID 392
Symbol ARHGAP1
Synonyms CDC42GAP|RHOGAP|RHOGAP1|p50rhoGAP
Description Rho GTPase activating protein 1
Reference MIM:602732|HGNC:HGNC:673|Ensembl:ENSG00000175220|HPRD:04108|Vega:OTTHUMG00000166567
Gene type protein-coding
Map location 11p11.2
Pascal p-value 8.095E-9
Sherlock p-value 0.425
Support INTRACELLULAR TRAFFICKING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MATN2 0.68 0.73
ZNF831 0.66 0.65
KIAA1772 0.63 0.61
VWA5A 0.63 0.61
SSTR4 0.62 0.60
AMZ1 0.61 0.63
MINK1 0.60 0.71
LRMP 0.59 0.52
NHSL2 0.59 0.65
BAIAP3 0.58 0.67
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL27 -0.36 -0.58
RPS13P2 -0.34 -0.53
RPS15A -0.34 -0.56
RPL31 -0.34 -0.55
RPS23 -0.34 -0.53
RPS7 -0.34 -0.52
RPS3AP47 -0.34 -0.50
RPL35 -0.34 -0.55
UXT -0.34 -0.53
RPL24 -0.33 -0.55

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA RHO PATHWAY 32 23 All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 45 37 All SZGR 2.0 genes in this pathway
PID CDC42 REG PATHWAY 30 22 All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 38 25 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 113 81 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG UP 44 29 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 100 75 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 1 51 33 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS 148 97 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151 100 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
ROSS AML WITH AML1 ETO FUSION 76 55 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 6Q21 DELETION 20 15 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C5 21 11 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178 121 All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 39 26 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222 139 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
ITO PTTG1 TARGETS DN 9 7 All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS DN 28 18 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221 150 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 87 66 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 88 68 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway