Gene Page:LBP

概括?
基因 3929
象征 LBP
Synonyms BPIFD2
Description lipopolysaccharide binding protein
Reference MIM：151990|HGNC:HGNC:6517|Ensembl:ENSG00000129988|HPRD:07175|Vega:OTTHUMG00000032447
Gene type protein-coding
Map location 20q11.23
Pascal p-value 0.826

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TGFBRAP1 0.95 0.95
AC097382.4 0.94 0.94
DHX37 0.94 0.95
SREBF2 0.94 0.95
Neurl4 0.93 0.95
CLIP2 0.93 0.94
DIP2C 0.93 0.94
FOXK2 0.93 0.95
KIAA1967 0.93 0.94
BICD2 0.93 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.79 -0.86
MT-CO2 -0.77 -0.86
AF347015.27 -0.76 -0.84
AF347015.21 -0.75 -0.91
AF347015.33 -0.74 -0.81
AC021016.1 -0.74 -0.82
FXYD1 -0.73 -0.80
AF347015.8 -0.73 -0.84
MT-CYB -0.73 -0.81
HIGD1B -0.73 -0.82

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005102 receptor binding ISS Neurotransmitter (GO term level: 4) 2477488
GO:0001530 lipopolysaccharide binding IEA -
GO:0008289 lipid binding IEA -
GO:0043498 cell surface binding ISS 2477488
GO:0051636 Gram-negative bacterial cell surface binding IDA 11528597
GO:0051636 Gram-negative bacterial cell surface binding ISS 2402637
GO:0051637 革兰氏阳性细菌细胞表面结合 IDA 12932360
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0002281 macrophage activation during immune response ISS 2402637
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway IDA 11528597
GO:0006968 cellular defense response ISS 2402637
GO:0006953 acute-phase response IEP 12932360
GO:0006953 acute-phase response ISS 2477488
GO:0006869 lipid transport IEA -
GO:0008228 opsonization IC 12932360
GO:0008228 opsonization ISS 2477488
GO:0015920 lipopolysaccharide transport IDA 8985160
GO:0032757 positive regulation of interleukin-8 production IDA 8409400
GO:0032496 对脂多糖的反应 IDA 8409400|11739189
GO:0032490 detection of molecule of bacterial origin IDA 11528597
GO:0032760 positive regulation of tumor necrosis factor production IDA 8409400
GO:0032760 positive regulation of tumor necrosis factor production ISS 2402637
GO：0032755 positive regulation of interleukin-6 production IDA 8409400
GO:0032720 negative regulation of tumor necrosis factor production IDA 11739189
GO：0031663 lipopolysaccharide-mediated signaling pathway IDA 8409400|11739189
GO:0043032 positive regulation of macrophage activation IDA 8409400
GO:0050830 defense response to Gram-positive bacterium IC 12932360
GO:0050830 defense response to Gram-positive bacterium IEP 12932360
GO：0050829 defense response to Gram-negative bacterium ISS 2402637
GO:0045087 先天免疫反应 IC 12932360
GO:0045087 先天免疫反应 ISS 2477488
GO:0060265 positive regulation of respiratory burst during acute inflammatory response ISS -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region 经验 2477488|9665271
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IDA 2402637|11528597
GO:0005615 extracellular space ISS 2477488
GO:0005634 nucleus IDA 18029348

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 该途径中的所有SZGR 2.0基因
BIOCARTA GSK3 PATHWAY 27 26 该途径中的所有SZGR 2.0基因
PID IL6 7 PATHWAY 47 40 该途径中的所有SZGR 2.0基因
REACTOME INNATE IMMUNE SYSTEM 279 178 该途径中的所有SZGR 2.0基因
REACTOME IMMUNE SYSTEM 933 616 该途径中的所有SZGR 2.0基因
REACTOME TOLL RECEPTOR CASCADES 118 84 该途径中的所有SZGR 2.0基因
CASTELLANO NRAS TARGETS UP 68 41 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 该途径中的所有SZGR 2.0基因
DAUER STAT3 TARGETS UP 49 35 该途径中的所有SZGR 2.0基因
Schaeffer前列腺开发48小时DN 428 306 该途径中的所有SZGR 2.0基因
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS DN 357 212 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
NADLER OBESITY UP 61 34 该途径中的所有SZGR 2.0基因
阿布得生活信号1 46 29 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 该途径中的所有SZGR 2.0基因
URS ADIPOCYTE DIFFERENTIATION UP 74 51 该途径中的所有SZGR 2.0基因
CUI TCF21 TARGETS UP 37 27 该途径中的所有SZGR 2.0基因
MCLACHLAN DENTAL CARIES DN 245 144 该途径中的所有SZGR 2.0基因
CUI TCF21 TARGETS 2 UP 428 266 该途径中的所有SZGR 2.0基因
HAN JNK SINGALING DN 39 27 该途径中的所有SZGR 2.0基因
MCLACHLAN DENTAL CARIES UP 253 147 该途径中的所有SZGR 2.0基因
LEIN CHOROID PLEXUS MARKERS 103 61 该途径中的所有SZGR 2.0基因
COATES MACROPHAGE M1 VS M2 DN 78 44 该途径中的所有SZGR 2.0基因
MARTINEZ RB1 TARGETS DN 543 317 该途径中的所有SZGR 2.0基因
MARTINEZ TP53 TARGETS UP 602 364 该途径中的所有SZGR 2.0基因
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 该途径中的所有SZGR 2.0基因
乳腺癌萧述三腔L B DN 564 326 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER ERBB2 UP 147 83 该途径中的所有SZGR 2.0基因
QI PLASMACYTOMA DN 100 63 该途径中的所有SZGR 2.0基因
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 该途径中的所有SZGR 2.0基因
Ichiba移植与宿主疾病35D UP 131 79 该途径中的所有SZGR 2.0基因
SWEET LUNG CANCER KRAS UP 491 316 该途径中的所有SZGR 2.0基因
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 LCP WITH H3K4ME3 162 80 该途径中的所有SZGR 2.0基因
CAIRO LIVER DEVELOPMENT DN 222 141 该途径中的所有SZGR 2.0基因
KAMIKUBO MYELOID CEBPA NETWORK 28 19 该途径中的所有SZGR 2.0基因
STAMBOLSKY TARGETS OF MUTATED TP53 DN 50 24 该途径中的所有SZGR 2.0基因
CHYLA CBFA2T3 TARGETS UP 387 225 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS DN 1972 1213 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
LIM MAMMARY LUMINAL PROGENITOR UP 58 30 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-500 162 168 m8 hsa-miR-500 AUGCACCUGGGCAAGGAUUCUG