Gene Page:ldha

Summary？
基因 3939
象征 ldha
Synonyms GSD11|HEL-S-133P|LDHM|PIG19
Description 乳酸脱氢酶A。
Reference MIM：150000|HGNC:HGNC:6535|ENSEMBL：ENSG00000134333|HPRD：01025|Vega:OTTHUMG00000167721
基因类型 蛋白质编码
Map location 11P15.4
pascal p-value 0.797
Sherlock p-value 0.02
胎儿β -1.355
主持人 Myers' cis & trans
Support 细胞代谢
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
G2CDB.HUMAN_CLATHRIN
g2cdb.human_synaptosom
G2CDB.HUMANNRC
g2cdb.humanpsd
G2CDB.HUMANPSP
CompositeSet

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
表达 Meta-analysis of gene expression p价值：1.65

Section I. Genetics and epigenetics annotation

@EQTL注释

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS10994209 Chr10 61877705 ldha 3939 0.04 反式

第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene pearson's Correlation 斯皮尔曼的相关性
AC079061.1 0.88 0.85
RNF19A 0.88 0.85
ptprk 0.86 0.81
chn2 0.86 0.87
RP11-791G16.2 0.84 0.84
DOCK9 0.84 0.84
MEF2C 0.83 0.79
FAM81A 0.82 0.81
3月1日 0.82 0.81
RHOBTB1 0.82 0.81
Top 10 negatively co-expressed genes
Gene pearson's Correlation 斯皮尔曼的相关性
MT-CO2 -0.62 -0.64
AF347015.31 -0.62 -0.64
AF347015.2 -0.61 -0.66
HSD17B14 -0.61 -0.67
AF347015.8 -0.60 -0.63
mt-cyb -0.60 -0.61
AF347015.33 -0.59 -0.60
ACSF2 -0.59 -0.68
AF347015.26 -0.58 -0.60
AF347015.27 -0.58 -0.59

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IPI 15231747|17220478
去：0004459 L乳酸脱氢酶活性 TAS 2334430
GO：0016491 氧化还原酶活性 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO：0019642 厌氧糖酵解 IEA -
GO:0044262 cellular carbohydrate metabolic process IEA -
GO：0055114 还原氧化 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0005829 细胞质 TAS 2434947
去：0005737 cytoplasm IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG GLYCOLYSIS GLUCONEOGENESIS 62 41 All SZGR 2.0 genes in this pathway
Kegg半胱氨酸和蛋氨酸代谢 34 24 All SZGR 2.0 genes in this pathway
Kegg丙酮酸代谢 40 26 All SZGR 2.0 genes in this pathway
Kegg丙酸代谢 33 22 All SZGR 2.0 genes in this pathway
Biocarta HIF途径 15 12 All SZGR 2.0 genes in this pathway
Biocarta SARS途径 10 5 All SZGR 2.0 genes in this pathway
PID MYC活动途径 79 62 All SZGR 2.0 genes in this pathway
PID HIF1 TFPathway 66 52 All SZGR 2.0 genes in this pathway
反应组丙酮酸代谢和柠檬酸TCA循环 48 32 All SZGR 2.0 genes in this pathway
Reactome TCA循环和呼吸电子传输 141 85 All SZGR 2.0 genes in this pathway
反应组丙酮酸代谢 19 14 All SZGR 2.0 genes in this pathway
冬天缺氧了 92 57 All SZGR 2.0 genes in this pathway
Liu Sox4靶向DN 309 191 All SZGR 2.0 genes in this pathway
casorelli急性临时细胞白血病DN 663 425 All SZGR 2.0 genes in this pathway
Horiuchi WTAP目标DN 310 188 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 All SZGR 2.0 genes in this pathway
Mullighan NPM1突变签名2 DN 77 46 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 All SZGR 2.0 genes in this pathway
多德鼻咽癌DN 1375 806 All SZGR 2.0 genes in this pathway
环氧素DN的浓凋亡 172 112 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment 536 340 All SZGR 2.0 genes in this pathway
Darwiche皮肤肿瘤启动子 142 96 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162 104 All SZGR 2.0 genes in this pathway
Darwiche Papilloma风险高 147 101 All SZGR 2.0 genes in this pathway
darwiche鳞状细胞癌 146 104 All SZGR 2.0 genes in this pathway
Appierto对Fenretinide DN的反应 51 35 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN 47 34 All SZGR 2.0 genes in this pathway
Teramoto OPN目标集群4 13 8 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向神经上皮 176 111 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向 414 287 All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌 358 245 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络 779 480 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
洛佩兹MBD目标 957 597 All SZGR 2.0 genes in this pathway
里克曼肿瘤分化了井和DN不良 382 224 All SZGR 2.0 genes in this pathway
Benporath Myc Max目标 775 494 All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS 53 35 All SZGR 2.0 genes in this pathway
pENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
pOMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP 62 38 All SZGR 2.0 genes in this pathway
西葫芦转移 43 24 All SZGR 2.0 genes in this pathway
Schuhmacher MYC的目标 80 57 All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP 45 30 All SZGR 2.0 genes in this pathway
pENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
KIM HYPOXIA 25 21 All SZGR 2.0 genes in this pathway
kaab失败的心房DN 141 99 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 64 47 All SZGR 2.0 genes in this pathway
哈里斯缺氧 81 64 All SZGR 2.0 genes in this pathway
伯顿成生成4 48 32 All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 36 32 All SZGR 2.0 genes in this pathway
Kaab失败心室DN 41 28 All SZGR 2.0 genes in this pathway
Gerhold脂肪形成 49 40 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时DN的响应 911 527 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应 1011 592 All SZGR 2.0 genes in this pathway
肺癌和巨噬细胞的钟分泌组 77 50 All SZGR 2.0 genes in this pathway
肺癌和内皮的钟分泌组 66 47 All SZGR 2.0 genes in this pathway
肺癌和成纤维细胞的钟分泌组 132 93 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170 107 All SZGR 2.0 genes in this pathway
阿塞维多肝癌DN 540 340 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
级结肠癌 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
马洛尼对17AAG DN的回应 79 45 All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应 342 220 All SZGR 2.0 genes in this pathway
冬季缺氧metagene 242 168 All SZGR 2.0 genes in this pathway
Mootha PGC 420 269 All SZGR 2.0 genes in this pathway
HUNSBERGER EXERCISE REGULATED GENES 31 26 All SZGR 2.0 genes in this pathway
Nutt GBM与AO胶质瘤 46 34 All SZGR 2.0 genes in this pathway
甜蜜的肺部通过R KRAS UP 491 316 All SZGR 2.0 genes in this pathway
霍夫曼大到小淋巴细胞向上 163 102 All SZGR 2.0 genes in this pathway
骨髓瘤与成熟B淋巴细胞中的Shaffer IRF4靶标 101 76 All SZGR 2.0 genes in this pathway
活化B淋巴细胞中的Shaffer IRF4靶标 81 66 All SZGR 2.0 genes in this pathway
Hsiao家政基因 389 245 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤CD2 DN 46 29 All SZGR 2.0 genes in this pathway
dang myc的目标 143 100 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
YAO对孕酮簇10的时间反应10 69 38 All SZGR 2.0 genes in this pathway
穆萨糖异生 32 23 All SZGR 2.0 genes in this pathway
Noushmehr GBM被甲基化沉默 50 32 All SZGR 2.0 genes in this pathway
Vandesluis Commd1目标3 89 50 All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN 882 538 All SZGR 2.0 genes in this pathway
CTBP1和SATB1的Purbey目标 87 52 All SZGR 2.0 genes in this pathway
SPI1和FLI1 DN的Juban目标 92 60 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-34/449 257 264 1A，M8 hsa-miR-34abrain uggcaguguuaguguguuuu
hsa-miR-34c Aggcaguguaguagcugauugc
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
HSA-MIR-449B AGGCAGUGUAUUGUUAGCUGGC